Exploiting the Anti-HIV-1 Activity of Acyclovir: Suppression of Primary and Drug-Resistant HIV Isolates and Potentiation of the Activity by Ribavirin

• Published in: Antimicrobial Agents and Chemotherapy Vol. 56; no. 5; pp. 2604 - 2611
• Main Authors: Vanpouille, Christophe, Lisco, Andrea, Introini, Andrea, Grivel, Jean-Charles, Munawwar, Arshi, Merbah, Melanie, Schinazi, Raymond F, Derudas, Marco, McGuigan, Christopher, Balzarini, Jan, Margolis, Leonid
• Format: Journal Article
• Language: English
• Published: Washington, DC American Society for Microbiology 01.05.2012
• Subjects: Acyclovir; Acyclovir - pharmacology; Anti-HIV Agents; Anti-HIV Agents - pharmacology; Antibiotics. Antiinfectious agents. Antiparasitic agents; Antiviral activity; Antiviral Agents; antiviral properties; Biological and medical sciences; Cell Line; Clinical trials; combination drug therapy; Data processing; DNA; drug effects; Drug resistance; Drug Resistance, Viral; Drug Resistance, Viral - drug effects; Drug Synergism; drugs; Elongation; guanine; Herpes simplex virus 2; highly active antiretroviral therapy; HIV Fusion Inhibitors; HIV Fusion Inhibitors - pharmacology; HIV infections; HIV Infections - virology; HIV-1; HIV-1 - drug effects; HIV-1 - physiology; Human immunodeficiency virus; Human immunodeficiency virus 1; Human viral diseases; Humans; Immunodeficiencies; Immunodeficiencies. Immunoglobulinopathies; Immunopathology; Infectious diseases; Lamivudine; Lamivudine - pharmacology; Medical sciences; Nevirapine; Nevirapine - pharmacology; nucleoside reverse transcriptase inhibitors; Palatine Tonsil; Palatine Tonsil - drug effects; Palatine Tonsil - virology; patients; pharmacology; Pharmacology. Drug treatments; physiology; Potentiation; Protease Inhibitors; Protease Inhibitors - pharmacology; Proteinase inhibitors; Replication; Ribavirin; Ribavirin - pharmacology; Survival; T-Lymphocytes; T-Lymphocytes - drug effects; T-Lymphocytes - virology; Tissue Culture Techniques; valacyclovir; Viral diseases; Viral diseases of the lymphoid tissue and the blood. Aids; virology; virus replication; Zidovudine; Zidovudine - pharmacology; Potentiation; Immunopathology; Acyclic nucleoside; Purine nucleoside; Antiretroviral agent; Treatment resistance; HIV-1 virus; Suppression; Retroviridae; AIDS; Immune deficiency; Lentivirus; Biological activity; Ribavirin; Infection; Virus; Viral disease; Primary; Aciclovir; Nucleoside analog; Antiviral; Isolate; Human immunodeficiency virus; DNA polymerase inhibitor

Multiple clinical trials have demonstrated that herpes simplex virus 2 (HSV-2) suppressive therapy using acyclovir (ACV) or valacyclovir in HIV-1/HSV-2-infected persons increased the patient's survival and decreased the HIV-1 load. It has been shown that the incorporation of ACV-monophosphate i...