Positron Emission Tomography Imaging of the Endocannabinoid System: Opportunities and Challenges in Radiotracer Development

• Published in: Journal of medicinal chemistry Vol. 64; no. 1; pp. 123 - 149
• Main Authors: Hou, Lu, Rong, Jian, Haider, Achi, Ogasawara, Daisuke, Varlow, Cassis, Schafroth, Michael A., Mu, Linjing, Gan, Jiefeng, Xu, Hao, Fowler, Christopher J., Zhang, Ming-Rong, Vasdev, Neil, Ametamey, Simon, Cravatt, Benjamin F., Wang, Lu, Liang, Steven H.
• Format: Journal Article
• Language: English
• Published: United States American Chemical Society 14.01.2021
• Subjects: Amidohydrolases - antagonists & inhibitors; Animals; Biomarkers - metabolism; Brain - diagnostic imaging; Brain - metabolism; Endocannabinoids - metabolism; Enzyme Inhibitors - pharmacology; Humans; Positron-Emission Tomography - methods; Receptors, Cannabinoid - metabolism
• ISSN: 0022-2623; 1520-4804; 1520-4804
• DOI: 10.1021/acs.jmedchem.0c01459

The endocannabinoid system (ECS) is involved in a wide range of biological functions and comprises cannabinoid receptors and enzymes responsible for endocannabinoid synthesis and degradation. Over the past 2 decades, significant advances toward developing drugs and positron emission tomography (PET)...