The Two-Component Regulatory System mtrAB Is Required for Morphotypic Multidrug Resistance in Mycobacterium avium

Classifications Services AAC Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit StumbleUpon Twitter current issue AAC About AAC Subscribers Authors Reviewers Advertisers Inquiries from the Press Permissions & Commerc...

Full description

Saved in:
Bibliographic Details
Published inAntimicrobial Agents and Chemotherapy Vol. 50; no. 2; pp. 461 - 468
Main Authors CANGELOSI, Gerard A, DO, Julie S, FREEMAN, Robert, BENNETT, John G, SEMRET, Makeda, BEHR, Marcel A
Format Journal Article
LanguageEnglish
Published Washington, DC American Society for Microbiology 01.02.2006
Subjects
Antibiotics. Antiinfectious agents. Antiparasitic agents
ATP-Binding Cassette Transporters
ATP-Binding Cassette Transporters - genetics
ATP-Binding Cassette Transporters - physiology
Bacterial Proteins
Bacterial Proteins - genetics
Bacterial Proteins - physiology
Biological and medical sciences
Cell Line
Cell Wall - chemistry
Cell Wall - metabolism
Drug Resistance, Multiple, Bacterial
Humans
Mechanisms of Resistance
Medical sciences
Mycobacterium avium
Mycobacterium avium Complex
Mycobacterium avium Complex - drug effects
Mycobacterium avium Complex - growth & development
Mycobacterium avium Complex - metabolism
Permeability
Pharmacology. Drug treatments
RNA-Binding Proteins
RNA-Binding Proteins - genetics
RNA-Binding Proteins - physiology
Transcription Factors
Transcription Factors - genetics
Transcription Factors - physiology
Antineoplastic agent
Treatment resistance
Mycobacteriales
Multiple resistance
Mycobacteriaceae
Mycobacterium avium
Bacteria
Actinomycetes
Online AccessGet full text

Cover

Abstract Classifications Services AAC Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit StumbleUpon Twitter current issue AAC About AAC Subscribers Authors Reviewers Advertisers Inquiries from the Press Permissions & Commercial Reprints ASM Journals Public Access Policy AAC RSS Feeds 1752 N Street N.W. • Washington DC 20036 202.737.3600 • 202.942.9355 fax • journals@asmusa.org Print ISSN: 0066-4804 Online ISSN: 1098-6596 Copyright © 2014 by the American Society for Microbiology.   For an alternate route to AAC .asm.org, visit: AAC       
AbstractList Clinical isolates of the opportunistic pathogen Mycobacterium avium complex (MAC) undergo a reversible switch between red and white colony morphotypes on agar plates containing the lipoprotein stain Congo red. Compared to their isogenic red counterparts, white morphotypic variants are more virulent and more resistant to multiple antibiotics. This report shows that the two-component regulatory system mtrAB is required for the red-to-white switch as well as for other morphotypic switches of MAC. A mutant with a transposon insertion in the histidine protein kinase gene mtrB was isolated from a morphotypically white parent clone. The mutant resembled a naturally occurring red morphotypic variant in that it stained with Congo red, was sensitive to multiple antibiotics, and was permeable by a fluorescent DNA stain. However, it differed from a red variant in that it could not switch to the white or transparent morphotype, and it could not survive intracellularly within macrophage-like cells. Transcomplementation with a cloned wild-type mtrB gene restored to the mutant the ability to form impermeable, drug-resistant white and transparent variants. Quantitative reverse transcriptase PCR showed that mtrB was required for the normal expression of cell surface Mce proteins, some of which are up-regulated in the red-to-white switch. The results indicate that mtrAB functions in regulating the composition and permeability of mycobacterial cell walls and plays a role in the reversible colony type switches of MAC.
Clinical isolates of the opportunistic pathogen Mycobacterium avium complex (MAC) undergo a reversible switch between red and white colony morphotypes on agar plates containing the lipoprotein stain Congo red. Compared to their isogenic red counterparts, white morphotypic variants are more virulent and more resistant to multiple antibiotics. This report shows that the two-component regulatory system mtrAB is required for the red-to-white switch as well as for other morphotypic switches of MAC. A mutant with a transposon insertion in the histidine protein kinase gene mtrB was isolated from a morphotypically white parent clone. The mutant resembled a naturally occurring red morphotypic variant in that it stained with Congo red, was sensitive to multiple antibiotics, and was permeable by a fluorescent DNA stain. However, it differed from a red variant in that it could not switch to the white or transparent morphotype, and it could not survive intracellularly within macrophage-like cells. Transcomplementation with a cloned wild-type mtrB gene restored to the mutant the ability to form impermeable, drug-resistant white and transparent variants. Quantitative reverse transcriptase PCR showed that mtrB was required for the normal expression of cell surface Mce proteins, some of which are up-regulated in the red-to-white switch. The results indicate that mtrAB functions in regulating the composition and permeability of mycobacterial cell walls and plays a role in the reversible colony type switches of MAC.
Classifications Services AAC Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit StumbleUpon Twitter current issue AAC About AAC Subscribers Authors Reviewers Advertisers Inquiries from the Press Permissions & Commercial Reprints ASM Journals Public Access Policy AAC RSS Feeds 1752 N Street N.W. • Washington DC 20036 202.737.3600 • 202.942.9355 fax • journals@asmusa.org Print ISSN: 0066-4804 Online ISSN: 1098-6596 Copyright © 2014 by the American Society for Microbiology.   For an alternate route to AAC .asm.org, visit: AAC       
ABSTRACT Clinical isolates of the opportunistic pathogen Mycobacterium avium complex (MAC) undergo a reversible switch between red and white colony morphotypes on agar plates containing the lipoprotein stain Congo red. Compared to their isogenic red counterparts, white morphotypic variants are more virulent and more resistant to multiple antibiotics. This report shows that the two-component regulatory system mtrAB is required for the red-to-white switch as well as for other morphotypic switches of MAC. A mutant with a transposon insertion in the histidine protein kinase gene mtrB was isolated from a morphotypically white parent clone. The mutant resembled a naturally occurring red morphotypic variant in that it stained with Congo red, was sensitive to multiple antibiotics, and was permeable by a fluorescent DNA stain. However, it differed from a red variant in that it could not switch to the white or transparent morphotype, and it could not survive intracellularly within macrophage-like cells. Transcomplementation with a cloned wild-type mtrB gene restored to the mutant the ability to form impermeable, drug-resistant white and transparent variants. Quantitative reverse transcriptase PCR showed that mtrB was required for the normal expression of cell surface Mce proteins, some of which are up-regulated in the red-to-white switch. The results indicate that mtrAB functions in regulating the composition and permeability of mycobacterial cell walls and plays a role in the reversible colony type switches of MAC.
Author Marcel A. Behr
Makeda Semret
Julie S. Do
Gerard A. Cangelosi
John G. Bennett
Robert Freeman
AuthorAffiliation Seattle Biomedical Research Institute, Seattle, Washington, 1 McGill University Health Center, Montreal, Canada 2
AuthorAffiliation_xml – name: Seattle Biomedical Research Institute, Seattle, Washington, 1 McGill University Health Center, Montreal, Canada 2
Author_xml – sequence: 1
  givenname: Gerard A
  surname: CANGELOSI
  fullname: CANGELOSI, Gerard A
  organization: Seattle Biomedical Research Institute, Seattle, Washington, United States
– sequence: 2
  givenname: Julie S
  surname: DO
  fullname: DO, Julie S
  organization: Seattle Biomedical Research Institute, Seattle, Washington, United States
– sequence: 3
  givenname: Robert
  surname: FREEMAN
  fullname: FREEMAN, Robert
  organization: Seattle Biomedical Research Institute, Seattle, Washington, United States
– sequence: 4
  givenname: John G
  surname: BENNETT
  fullname: BENNETT, John G
  organization: Seattle Biomedical Research Institute, Seattle, Washington, United States
– sequence: 5
  givenname: Makeda
  surname: SEMRET
  fullname: SEMRET, Makeda
  organization: McGill University Health Center, Montreal, Canada
– sequence: 6
  givenname: Marcel A
  surname: BEHR
  fullname: BEHR, Marcel A
  organization: McGill University Health Center, Montreal, Canada
BackLink http://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=17473544$$DView record in Pascal Francis
https://www.ncbi.nlm.nih.gov/pubmed/16436697$$D View this record in MEDLINE/PubMed
BookMark eNqFkctu1DAUhi1URKeFRwB5A7sE2_EtG6TpiEuljpBgWFuOx5m4SuKMnbTK2-NoRi2surAtn_Od638FLnrfWwDeY5RjTOTn9XqTM5STnHKcUS5zghB_BVYYlTLjrOQXYJUsPKMS0UtwFeM9Sn9WojfgEnNacF6KFTjuGgt3jz7b-G5IFfoR_rKHqdWjDzP8PcfRdrAbw_oG3sbkOk4u2D2sfYBbH4bGj_PgDNxO7ej2YTokJLo46t5Y6Hq4nY2vtBltcFMH9UO634LXtW6jfXd-r8Gfb193mx_Z3c_vt5v1XaZTj2MmCcMV2RNWWVmJAotCVqasuBDWIFQXVprFxmtdaI3LWlSUyYpraYqE16y4Bl9OeYep6uzepNGCbtUQXKfDrLx26n9P7xp18A8KL6tBS4JP5wTBHycbR9W5aGzb6t76KSqBBMGUFS-CuCwZEZQnkJ1AE3yMwdZP3WCkFlVVUlUxpIhKqqYj1aJqiiOnOB07ou79FPq0uReDPvw7_3Ops_YJ-HgGdDS6rUMSzcVnTlBRMEoTB09c4w7NY5JfpTaU1uapaPEXGznI7A
CODEN AACHAX
CitedBy_id crossref_primary_10_1039_C2MD20308A
crossref_primary_10_1128_JB_01920_06
crossref_primary_10_1111_j_1462_5822_2012_01776_x
crossref_primary_10_1080_08997659_2015_1007176
crossref_primary_10_1128_IAI_01273_12
crossref_primary_10_1038_srep16130
crossref_primary_10_2217_fmb_2021_0016
crossref_primary_10_1016_j_drup_2012_04_001
crossref_primary_10_1093_femspd_fty027
crossref_primary_10_15789_2220_7619_2013_1_7_14
crossref_primary_10_1128_AEM_01810_09
crossref_primary_10_1186_1471_2164_14_523
crossref_primary_10_1186_1471_2164_15_S7_S3
crossref_primary_10_1111_j_1364_3703_2006_00377_x
crossref_primary_10_1074_jbc_M701749200
crossref_primary_10_3390_antibiotics11121756
crossref_primary_10_1038_srep01109
crossref_primary_10_1016_j_tim_2006_08_005
crossref_primary_10_1016_j_micres_2020_126584
crossref_primary_10_1002_jcb_28792
crossref_primary_10_1128_JB_01682_07
crossref_primary_10_1007_s00232_017_9995_5
crossref_primary_10_1111_j_1365_2958_2010_07110_x
crossref_primary_10_1111_j_1365_2958_2006_05455_x
crossref_primary_10_15789_2220_7619_GDO_1220
crossref_primary_10_3389_fmicb_2021_633510
crossref_primary_10_1074_jbc_RA119_009449
crossref_primary_10_1128_microbiolspec_MGM2_0010_2013
crossref_primary_10_1186_s13099_023_00573_w
crossref_primary_10_1186_s12917_023_03715_z
crossref_primary_10_1128_MMBR_05004_11
crossref_primary_10_1016_j_micpath_2013_10_004
crossref_primary_10_1074_jbc_M112_346544
crossref_primary_10_2217_fmb_2019_0002
crossref_primary_10_1128_IAI_01120_10
crossref_primary_10_1111_j_1574_6968_2006_00456_x
crossref_primary_10_1016_S1472_9792_13_70007_6
crossref_primary_10_1016_j_micinf_2012_01_007
crossref_primary_10_1186_1471_2180_10_242
crossref_primary_10_1111_febs_15582
crossref_primary_10_3390_biology10020096
crossref_primary_10_1111_j_1365_2761_2007_00883_x
crossref_primary_10_3389_fmicb_2024_1415554
crossref_primary_10_1002_iub_1872
crossref_primary_10_1016_j_micpath_2009_01_010
crossref_primary_10_1016_j_abb_2020_108522
crossref_primary_10_1016_j_jmb_2019_01_004
crossref_primary_10_1111_j_1365_2958_2008_06308_x
crossref_primary_10_1186_1471_2180_12_204
crossref_primary_10_1080_01652176_2019_1641764
crossref_primary_10_1016_j_plasmid_2011_01_002
crossref_primary_10_1111_1758_2229_12629
crossref_primary_10_1038_ng_2747
crossref_primary_10_1080_22221751_2022_2069514
crossref_primary_10_1128_AEM_01633_06
crossref_primary_10_1016_j_ijantimicag_2015_02_018
Cites_doi 10.1128/IAI.66.6.2625-2631.1998
10.1073/pnas.2433882100
10.1128/IAI.68.6.3121-3128.2000
10.1111/j.1574-6968.1994.tb07194.x
10.1016/0923-2508(91)90117-S
10.1086/324523
10.1128/AAC.9.1.113
10.1128/jb.178.11.3314-3321.1996
10.1128/JB.187.7.2406-2415.2005
10.1111/j.1472-765X.1997.tb00013.x
10.1128/JB.185.16.5003-5006.2003
10.1016/j.tube.2004.02.002
10.1111/j.1365-2958.2003.03958.x
10.1128/JB.186.18.6332-6334.2004
10.1073/pnas.2134250100
10.1046/j.1462-5822.2001.00110.x
10.1074/jbc.270.45.27292
10.1128/iai.65.12.5262-5271.1997
10.1128/iai.62.5.1946-1951.1994
10.1128/JB.182.13.3832-3838.2000
10.1046/j.1365-2958.1999.01212.x
10.1046/j.1365-2958.1998.00774.x
10.1099/mic.0.26902-0
10.1099/00221287-147-3-527
10.1111/j.1365-2958.2004.04249.x
10.1099/13500872-145-6-1317
10.1128/IAI.70.7.3714-3726.2002
10.1016/0923-2508(94)90024-8
10.1074/jbc.M004010200
10.1128/jb.178.21.6357-6360.1996
10.1111/j.1574-695X.1997.tb01100.x
10.1128/AAC.48.9.3412-3418.2004
10.1111/j.1348-0421.1983.tb00601.x
10.1128/IAI.69.6.4185-4191.2001
ContentType Journal Article
Copyright 2006 INIST-CNRS
Copyright © 2006 American Society for Microbiology
Copyright © 2006, American Society for Microbiology 2006
Copyright_xml – notice: 2006 INIST-CNRS
– notice: Copyright © 2006 American Society for Microbiology
– notice: Copyright © 2006, American Society for Microbiology 2006
DBID IQODW
CGR
CUY
CVF
ECM
EIF
NPM
AAYXX
CITATION
7QL
7T7
8FD
C1K
FR3
P64
7X8
5PM
DOI 10.1128/AAC.50.2.461-468.2006
DatabaseName Pascal-Francis
Medline
MEDLINE
MEDLINE (Ovid)
MEDLINE
MEDLINE
PubMed
CrossRef
Bacteriology Abstracts (Microbiology B)
Industrial and Applied Microbiology Abstracts (Microbiology A)
Technology Research Database
Environmental Sciences and Pollution Management
Engineering Research Database
Biotechnology and BioEngineering Abstracts
MEDLINE - Academic
PubMed Central (Full Participant titles)
DatabaseTitle MEDLINE
Medline Complete
MEDLINE with Full Text
PubMed
MEDLINE (Ovid)
CrossRef
Engineering Research Database
Technology Research Database
Industrial and Applied Microbiology Abstracts (Microbiology A)
Bacteriology Abstracts (Microbiology B)
Biotechnology and BioEngineering Abstracts
Environmental Sciences and Pollution Management
MEDLINE - Academic
DatabaseTitleList

Engineering Research Database
MEDLINE - Academic
MEDLINE

CrossRef
Database_xml – sequence: 1
  dbid: NPM
  name: PubMed
  url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed
  sourceTypes: Index Database
– sequence: 2
  dbid: EIF
  name: MEDLINE
  url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search
  sourceTypes: Index Database
DeliveryMethod fulltext_linktorsrc
Discipline Medicine
Pharmacy, Therapeutics, & Pharmacology
Biology
EISSN 1098-6596
EndPage 468
ExternalDocumentID 10_1128_AAC_50_2_461_468_2006
1012-05
16436697
17473544
aac_50_2_461
Genre Research Support, Non-U.S. Gov't
Journal Article
Research Support, N.I.H., Extramural
GrantInformation_xml – fundername: NIAID NIH HHS
  grantid: R21-AI061006
– fundername: NIAID NIH HHS
  grantid: R01-AI25767
– fundername: NIAID NIH HHS
  grantid: R21 AI061006
GroupedDBID ---
.55
.GJ
08R
0R~
23M
2WC
39C
3O-
4.4
53G
5GY
5RE
5VS
6J9
AAPBV
AAUGY
ACGFO
ADBBV
AENEX
AFMIJ
AGNAY
AI.
ALMA_UNASSIGNED_HOLDINGS
AOIJS
BAWUL
BTFSW
C1A
CS3
DIK
E3Z
EBS
EJD
F5P
FRP
GX1
H13
HH5
HYE
HZ~
H~9
IQODW
J5H
K-O
KQ8
L7B
LSO
MVM
NEJ
O9-
OK1
P2P
RHF
RHI
RNS
RPM
RSF
TR2
UHB
VH1
W2D
W8F
WH7
WHG
WOQ
X7M
X7N
XOL
Y6R
ZA5
ZGI
ZXP
~A~
AGVNZ
CGR
CUY
CVF
ECM
EIF
NPM
-
0R
55
A
ABFLS
ADACO
ADBIT
BXI
GJ
HZ
AAYXX
CITATION
7QL
7T7
8FD
C1K
FR3
P64
7X8
5PM
ID FETCH-LOGICAL-a590t-8251b2d25be8b731738bc9b677ec00f3e8c17386fa3aa19f7b458b6a8c3b73f53
IEDL.DBID RPM
ISSN 0066-4804
IngestDate Tue Sep 17 21:08:15 EDT 2024
Fri Oct 25 08:10:50 EDT 2024
Sun Sep 29 07:46:50 EDT 2024
Thu Sep 12 17:50:58 EDT 2024
Tue Dec 28 13:59:06 EST 2021
Sat Sep 28 08:48:35 EDT 2024
Sun Oct 22 16:03:11 EDT 2023
Wed May 18 15:34:26 EDT 2016
IsDoiOpenAccess false
IsOpenAccess true
IsPeerReviewed true
IsScholarly true
Issue 2
Keywords Antineoplastic agent
Treatment resistance
Mycobacteriales
Multiple resistance
Mycobacteriaceae
Mycobacterium avium
Bacteria
Actinomycetes
Language English
License CC BY 4.0
LinkModel DirectLink
MergedId FETCHMERGED-LOGICAL-a590t-8251b2d25be8b731738bc9b677ec00f3e8c17386fa3aa19f7b458b6a8c3b73f53
Notes ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
Corresponding author. Mailing address: Seattle Biomedical Research Institute, 307 Westlake Avenue N., Suite 500, Seattle, WA 98109. Phone: (206) 256-7200. Fax: (206) 256-7229. E-mail: Jerry.Cangelosi@sbri.org.
OpenAccessLink https://europepmc.org/articles/pmc1366905?pdf=render
PMID 16436697
PQID 19952746
PQPubID 23462
PageCount 8
ParticipantIDs pubmed_primary_16436697
highwire_asm_aac_50_2_461
proquest_miscellaneous_70721453
crossref_primary_10_1128_AAC_50_2_461_468_2006
pubmedcentral_primary_oai_pubmedcentral_nih_gov_1366905
asm2_journals_10_1128_AAC_50_2_461_468_2006
pascalfrancis_primary_17473544
proquest_miscellaneous_19952746
PublicationCentury 2000
PublicationDate 2006-02-01
PublicationDateYYYYMMDD 2006-02-01
PublicationDate_xml – month: 02
  year: 2006
  text: 2006-02-01
  day: 01
PublicationDecade 2000
PublicationPlace Washington, DC
PublicationPlace_xml – name: Washington, DC
– name: United States
PublicationTitle Antimicrobial Agents and Chemotherapy
PublicationTitleAbbrev AAC
PublicationTitleAlternate Antimicrob Agents Chemother
PublicationYear 2006
Publisher American Society for Microbiology
Publisher_xml – name: American Society for Microbiology
References 15469514 - Mol Microbiol. 2004 Oct;54(2):420-38
11709794 - J Infect Dis. 2001 Dec 1;184(11):1480-4
15049808 - Mol Microbiol. 2004 Apr;52(1):25-38
7988876 - FEMS Microbiol Lett. 1994 Oct 15;123(1-2):11-8
12897021 - J Bacteriol. 2003 Aug;185(16):5003-6
11238960 - Microbiology. 2001 Mar;147(Pt 3):527-33
14569030 - Proc Natl Acad Sci U S A. 2003 Oct 28;100(22):12989-94
15328105 - Antimicrob Agents Chemother. 2004 Sep;48(9):3412-8
7809478 - Res Microbiol. 1994 Mar-Apr;145(3):237-42
9449859 - Lett Appl Microbiol. 1997 Dec;25(6):437-41
10851001 - J Bacteriol. 2000 Jul;182(13):3832-8
1259385 - Antimicrob Agents Chemother. 1976 Jan;9(1):113-9
9537755 - FEMS Immunol Med Microbiol. 1997 Dec;19(4):297-305
10027986 - Mol Microbiol. 1999 Jan;31(2):715-24
11349098 - Infect Immun. 2001 Jun;69(6):4185-91
15207489 - Tuberculosis (Edinb). 2004;84(3-4):197-204
15073295 - Microbiology. 2004 Apr;150(Pt 4):853-64
6312275 - Microbiol Immunol. 1983;27(5):425-31
8655513 - J Bacteriol. 1996 Jun;178(11):3314-21
9393825 - Infect Immun. 1997 Dec;65(12):5262-71
12065514 - Infect Immun. 2002 Jul;70(7):3714-26
15342607 - J Bacteriol. 2004 Sep;186(18):6332-4
11073941 - J Biol Chem. 2001 Feb 9;276(6):3863-71
14663145 - Proc Natl Acad Sci U S A. 2003 Dec 23;100(26):15918-23
11298648 - Cell Microbiol. 2001 Apr;3(4):247-54
15774884 - J Bacteriol. 2005 Apr;187(7):2406-15
1871430 - Res Microbiol. 1991 May;142(4):437-43
8892841 - J Bacteriol. 1996 Nov;178(21):6357-60
10411258 - Microbiology. 1999 Jun;145 ( Pt 6):1317-24
7592990 - J Biol Chem. 1995 Nov 10;270(45):27292-8
10816453 - Infect Immun. 2000 Jun;68(6):3121-8
8168961 - Infect Immun. 1994 May;62(5):1946-51
9570407 - Mol Microbiol. 1998 Mar;27(6):1223-33
9596726 - Infect Immun. 1998 Jun;66(6):2625-31
e_1_3_2_26_2
e_1_3_2_27_2
e_1_3_2_28_2
e_1_3_2_29_2
e_1_3_2_20_2
e_1_3_2_21_2
e_1_3_2_22_2
e_1_3_2_23_2
e_1_3_2_24_2
e_1_3_2_25_2
e_1_3_2_9_2
e_1_3_2_15_2
e_1_3_2_8_2
e_1_3_2_16_2
e_1_3_2_7_2
e_1_3_2_17_2
e_1_3_2_6_2
e_1_3_2_18_2
e_1_3_2_19_2
e_1_3_2_30_2
e_1_3_2_32_2
e_1_3_2_10_2
e_1_3_2_31_2
e_1_3_2_5_2
e_1_3_2_11_2
e_1_3_2_34_2
e_1_3_2_4_2
e_1_3_2_12_2
e_1_3_2_33_2
e_1_3_2_3_2
e_1_3_2_13_2
e_1_3_2_2_2
e_1_3_2_14_2
e_1_3_2_35_2
References_xml – ident: e_1_3_2_16_2
  doi: 10.1128/IAI.66.6.2625-2631.1998
– ident: e_1_3_2_30_2
  doi: 10.1073/pnas.2433882100
– ident: e_1_3_2_6_2
  doi: 10.1128/IAI.68.6.3121-3128.2000
– ident: e_1_3_2_11_2
  doi: 10.1111/j.1574-6968.1994.tb07194.x
– ident: e_1_3_2_22_2
  doi: 10.1016/0923-2508(91)90117-S
– ident: e_1_3_2_21_2
  doi: 10.1086/324523
– ident: e_1_3_2_34_2
  doi: 10.1128/AAC.9.1.113
– ident: e_1_3_2_33_2
  doi: 10.1128/jb.178.11.3314-3321.1996
– ident: e_1_3_2_24_2
  doi: 10.1128/JB.187.7.2406-2415.2005
– ident: e_1_3_2_10_2
  doi: 10.1111/j.1472-765X.1997.tb00013.x
– ident: e_1_3_2_13_2
  doi: 10.1128/JB.185.16.5003-5006.2003
– ident: e_1_3_2_20_2
  doi: 10.1016/j.tube.2004.02.002
– ident: e_1_3_2_32_2
  doi: 10.1111/j.1365-2958.2003.03958.x
– ident: e_1_3_2_29_2
  doi: 10.1128/JB.186.18.6332-6334.2004
– ident: e_1_3_2_28_2
  doi: 10.1073/pnas.2134250100
– ident: e_1_3_2_5_2
  doi: 10.1046/j.1462-5822.2001.00110.x
– ident: e_1_3_2_7_2
  doi: 10.1074/jbc.270.45.27292
– ident: e_1_3_2_8_2
  doi: 10.1128/iai.65.12.5262-5271.1997
– ident: e_1_3_2_26_2
  doi: 10.1128/iai.62.5.1946-1951.1994
– ident: e_1_3_2_35_2
  doi: 10.1128/JB.182.13.3832-3838.2000
– ident: e_1_3_2_15_2
  doi: 10.1046/j.1365-2958.1999.01212.x
– ident: e_1_3_2_17_2
  doi: 10.1046/j.1365-2958.1998.00774.x
– ident: e_1_3_2_14_2
  doi: 10.1099/mic.0.26902-0
– ident: e_1_3_2_3_2
  doi: 10.1099/00221287-147-3-527
– ident: e_1_3_2_19_2
  doi: 10.1111/j.1365-2958.2004.04249.x
– ident: e_1_3_2_4_2
  doi: 10.1099/13500872-145-6-1317
– ident: e_1_3_2_9_2
  doi: 10.1128/IAI.70.7.3714-3726.2002
– ident: e_1_3_2_2_2
  doi: 10.1016/0923-2508(94)90024-8
– ident: e_1_3_2_12_2
  doi: 10.1074/jbc.M004010200
– ident: e_1_3_2_23_2
  doi: 10.1128/jb.178.21.6357-6360.1996
– ident: e_1_3_2_27_2
  doi: 10.1111/j.1574-695X.1997.tb01100.x
– ident: e_1_3_2_25_2
  doi: 10.1128/AAC.48.9.3412-3418.2004
– ident: e_1_3_2_18_2
  doi: 10.1111/j.1348-0421.1983.tb00601.x
– ident: e_1_3_2_31_2
  doi: 10.1128/IAI.69.6.4185-4191.2001
SSID ssj0006590
Score 2.1451876
Snippet Classifications Services AAC Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit...
Clinical isolates of the opportunistic pathogen Mycobacterium avium complex (MAC) undergo a reversible switch between red and white colony morphotypes on agar...
ABSTRACT Clinical isolates of the opportunistic pathogen Mycobacterium avium complex (MAC) undergo a reversible switch between red and white colony morphotypes...
Clinical isolates of the opportunistic pathogen Mycobacterium avium complex (MAC) undergo a reversible switch between red and white colony morphotypes on agar...
SourceID pubmedcentral
proquest
crossref
asm2
pubmed
pascalfrancis
highwire
SourceType Open Access Repository
Aggregation Database
Index Database
Publisher
StartPage 461
SubjectTerms Antibiotics. Antiinfectious agents. Antiparasitic agents
ATP-Binding Cassette Transporters
ATP-Binding Cassette Transporters - genetics
ATP-Binding Cassette Transporters - physiology
Bacterial Proteins
Bacterial Proteins - genetics
Bacterial Proteins - physiology
Biological and medical sciences
Cell Line
Cell Wall - chemistry
Cell Wall - metabolism
Drug Resistance, Multiple, Bacterial
Humans
Mechanisms of Resistance
Medical sciences
Mycobacterium avium
Mycobacterium avium Complex
Mycobacterium avium Complex - drug effects
Mycobacterium avium Complex - growth & development
Mycobacterium avium Complex - metabolism
Permeability
Pharmacology. Drug treatments
RNA-Binding Proteins
RNA-Binding Proteins - genetics
RNA-Binding Proteins - physiology
Transcription Factors
Transcription Factors - genetics
Transcription Factors - physiology
Title The Two-Component Regulatory System mtrAB Is Required for Morphotypic Multidrug Resistance in Mycobacterium avium
URI http://aac.asm.org/content/50/2/461.abstract
https://www.ncbi.nlm.nih.gov/pubmed/16436697
https://journals.asm.org/doi/10.1128/AAC.50.2.461-468.2006
https://search.proquest.com/docview/19952746
https://search.proquest.com/docview/70721453
https://pubmed.ncbi.nlm.nih.gov/PMC1366905
Volume 50
hasFullText 1
inHoldings 1
isFullTextHit
isPrint
link http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1Lj9MwEB7trgTigqC8wqP4gPbCJk0Tv3IsFasFVFRQV9pbZDvOUokmpWlB-feM89hSBELikBzisZ14ZuxxPPMNwKvMaBsJHfuJpNSnccZ8qZX2uUTj1YwzmwgX4Dz7yC8u6fsrdnUErI-FaZz2jV4GxddVUCy_NL6V65UZ9X5io_lsOo45burY6BiOUUD7LXo3_XLW_ljBtdSnMqRd2A7Ow6PJZBqwMIgCynHjxGVz8uBgQ3FZxhZdhhVVraLDJaqHDXZek6rCgcvbjBd_Mkl_96z8Zak6vwd3OxuTTNpvuQ9HthjArTbrZD2A27PuPH0Ap_MWubo-I4t9IFZ1Rk7JfI9pXT-Ab1hMFj9K380fZYH9ks9tFvtyU5MW9pystpvJG_KuwiLnX2wzghYxmZXIynJbr5eGNOG-2WZ3jSSVs1xR5MiyILPa4LzS4EbvVkR9x_tDuDx_u5he-F22Bl_hiG99FwOroyxi2kot0CyJpTaJ5kJYE4Z5bKVxz3iuYqXGSS40ZVJzJU2M5DmLH8FJgR_wBIjJwsjIPOYoKjS0kRqrPBFMS8tjTVXiwWvHp7RTtyptdjKRTJHBKQvTKEUG4yVdkk3uQdCzM123EB7_quD1TE-xn1Qpc0PkwfBACvYtCpfEmVIPXvZikaKmuuMXVdhyhy-ZJCwSlP-dQjiwOspiDx63YrRvvZNQD8SBgN0QOJTwwxJUngYtvFOWp_9d8xncaf87OR-e53Cy3ezsC7TEtnoIxx8-yWGjfz8B_hgxEw
link.rule.ids 230,315,730,783,787,888,27936,27937,53804,53806
linkProvider National Library of Medicine
linkToHtml http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1Lj9MwELaWRTwuCMorPHZ9QHthk6bxM8dSserCZlWhrrS3yHYcqEST0rSg_HvGeWwpAiFxSA7x2E48M_Y4nvkGoTeZ0TYSmvixpNSnJGO-1Er7XILxakaZjYULcE4u-fSKfrhm1weI9bEwjdO-0Yug-LoMisWXxrdytTTD3k9sOEsmI8JhU8eGt9Bt0NeQ9pv0bgLmrP21AqupT6G4C9yBmXg4Hk8CFgZRQDlsnbhszh4ccCgszNCmy7GiqmW0v0j1wMHOb1JVMHR5m_PiT0bp776VvyxWZw_Rg87KxOP2ax6hA1sM0J0272Q9QHeT7kR9gE5mLXZ1fYrnu1Cs6hSf4NkO1bp-jL5BMZ7_KH03g5QF9Is_tXnsy3WNW-BzvNysx-_weQVFzsPYZhhsYpyUwMxyU68WBjcBv9l6-xlIKme7gtDhRYGT2sDM0iBHb5dYfYf7E3R19n4-mfpdvgZfwYhvfBcFq6MsYtpKLcAwIVKbWHMhrAnDnFhp3DOeK6LUKM6FpkxqrqQhQJ4z8hQdFvABzxE2WRgZmRMOwkJDG6mRymPBtLScaKpiD711fEo7havSZi8TyRQYnLIwjVJgMFzSpdnkHgp6dqarFsTjXxW8nukp9JMqZW6IPHS0JwW7FoVL40yph457sUhBV90BjCpsuYWXjGMWCcr_TiEcXB1lxEPPWjHatd5JqIfEnoDdEDic8P0SUJ8GL7xTlxf_XfMY3ZvOk4v04vzy40t0v_0L5Tx6XqHDzXprX4NdttFHjRb-BPwcM3Q
linkToPdf http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1Lj9MwELZgESsuCMorPHZ9QHth82j8zLEUql2gqwp1pb1FtuNAJZqUpgXl3zPOY7tFICQOySEe24lnxh7HM98g9Doz2sZCEz-RlPqUZMyXWmmfSzBezTCziXABztMLfnZJP1yxqxupvhqnfaMXQfFtGRSLr41v5Wppwt5PLJxNx0PCYVPHwlWWh7fRHdDZiPcb9W4S5qz9vQIrqk9lRLvgHZiNw9FoHLAoiAPKYfvEZXP-4MBDYXGGdl2eFVUt4_2FqgcPdr6TqoLhy9u8F38yTH_3r7yxYE0eoPudpYlH7Rc9RLdsMUB329yT9QAdTrtT9QE6mbX41fUpnu_CsapTfIJnO2Tr-hH6DsV4_rP03SxSFtAv_tzmsi_XNW7Bz_Fysx69xecVFDkvY5thsIvxtASGlpt6tTC4CfrN1tsvQFI5-xUEDy8KPK0NzC4NevR2idUPuD9Gl5P38_GZ3-Vs8BWM-MZ3kbA6zmKmrdQCjBMitUk0F8KaKMqJlcY947kiSg2TXGjKpOZKGgLkOSNP0EEBH_AMYZNFsZE54SAwNLKxGqo8EUxLy4mmKvHQG8entFO6Km32M7FMgcEpi9I4BQbDJV2qTe6hoGdnumqBPP5VweuZnkI_qVLmmshDR3tSsGtRuFTOlHrouBeLFPTVHcKowpZbeMkkYbGg_O8UwkHWUUY89LQVo13rnYR6SOwJ2DWBwwrfLwEVajDDO5V5_t81j9Hh7N0k_XR-8fEFutf-iHJOPS_RwWa9ta_ANNvoo0YJfwFjuzSH
openUrl ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=The+Two-Component+Regulatory+System+mtrAB+Is+Required+for+Morphotypic+Multidrug+Resistance+in+Mycobacterium+avium&rft.jtitle=Antimicrobial+agents+and+chemotherapy&rft.au=Cangelosi%2C+Gerard+A&rft.au=Do%2C+Julie+S&rft.au=Freeman%2C+Robert&rft.au=Bennett%2C+John+G&rft.date=2006-02-01&rft.pub=American+Society+for+Microbiology&rft.issn=0066-4804&rft.eissn=1098-6596&rft.volume=50&rft.issue=2&rft.spage=461&rft.epage=468&rft_id=info:doi/10.1128%2FAAC.50.2.461-468.2006&rft.externalDocID=1012-05
thumbnail_l http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0066-4804&client=summon
thumbnail_m http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0066-4804&client=summon
thumbnail_s http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0066-4804&client=summon