Sensory TRP Channels in Three Dimensions

• Published in: Annual review of biochemistry Vol. 91; p. 629
• Main Authors: Diver, Melinda M, Lin King, John V, Julius, David, Cheng, Yifan
• Format: Journal Article
• Language: English
• Published: United States 21.06.2022
• Subjects: Cryoelectron Microscopy; Signal Transduction; Transient Receptor Potential Channels - chemistry; Transient Receptor Potential Channels - genetics; Transient Receptor Potential Channels - metabolism; sensory biology; membrane protein structure; cryo-EM; TRP channels

Transient receptor potential (TRP) ion channels are sophisticated signaling machines that detect a wide variety of environmental and physiological signals. Every cell in the body expresses one or more members of the extended TRP channel family, which consists of over 30 subtypes, each likely possess...