Efficacy of Posaconazole in Murine Experimental Sporotrichosis

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Published inAntimicrobial Agents and Chemotherapy Vol. 56; no. 5; pp. 2273 - 2277
Main Authors FERNANDEZ-SILVA, Fabiola, CAPILLA, Javier, MAYAYO, Emilio, GUARRO, Josep
Format Journal Article
LanguageEnglish
Published Washington, DC American Society for Microbiology 01.05.2012
Subjects
Administration, Oral
Amphotericin B
Amphotericin B - administration & dosage
Amphotericin B - therapeutic use
Animal models
Animals
Antibiotics. Antiinfectious agents. Antiparasitic agents
Antifungal Agents
Antifungal Agents - administration & dosage
Antifungal Agents - therapeutic use
Biological and medical sciences
Body weight
Disease Models, Animal
Dose-Response Relationship, Drug
Drug Administration Schedule
Drugs
Experimental Therapeutics
Histocytochemistry
Human mycoses
Infectious diseases
Liver
Liver - drug effects
Liver - microbiology
Male
Medical sciences
Mice
Microbial Sensitivity Tests
Minimum inhibitory concentration
Mycoses
Pharmacology. Drug treatments
Posaconazole
Species Specificity
Sporothrix
Sporothrix - drug effects
Sporothrix - physiology
Sporothrix schenckii
Sporotrichosis
Sporotrichosis - drug therapy
Sporotrichosis - microbiology
Sporotrichosis - mortality
Sporotrichosis - pathology
Survival
Survival Rate
Treatment Outcome
Triazoles
Triazoles - administration & dosage
Triazoles - therapeutic use
Tropical mycoses
Mycosis
Azole derivatives
Treatment efficiency
Rodentia
Sporotrichosis
Infection
Vertebrata
Antifungal agent
Mammalia
Mouse
Animal
Triazole derivatives
Posaconazole
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Abstract Classifications Services AAC Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit StumbleUpon Twitter current issue AAC About AAC Subscribers Authors Reviewers Advertisers Inquiries from the Press Permissions & Commercial Reprints ASM Journals Public Access Policy AAC RSS Feeds 1752 N Street N.W. • Washington DC 20036 202.737.3600 • 202.942.9355 fax • journals@asmusa.org Print ISSN: 0066-4804 Online ISSN: 1098-6596 Copyright © 2014 by the American Society for Microbiology.   For an alternate route to AAC .asm.org, visit: AAC       
AbstractList We developed a murine model of systemic sporotrichosis by using three strains of each of the two commonest species causing sporotrichosis, i.e., Sporothrix schenckii sensu stricto and Sporothrix brasiliensis, in order to evaluate the efficacy of posaconazole (PSC). The drug was administered at a dose of 2.5 or 5 mg/kg of body weight twice a day by gavage, and one group was treated with amphotericin B (AMB) as a control treatment. Posaconazole, especially at 5 mg/kg, showed good efficacy against all the strains tested, regardless of their MICs, as measured by prolonged survival, tissue burden reduction, and histopathology.
We developed a murine model of systemic sporotrichosis by using three strains of each of the two commonest species causing sporotrichosis, i.e., Sporothrix schenckii sensu stricto and Sporothrix brasiliensis , in order to evaluate the efficacy of posaconazole (PSC). The drug was administered at a dose of 2.5 or 5 mg/kg of body weight twice a day by gavage, and one group was treated with amphotericin B (AMB) as a control treatment. Posaconazole, especially at 5 mg/kg, showed good efficacy against all the strains tested, regardless of their MICs, as measured by prolonged survival, tissue burden reduction, and histopathology.
Classifications Services AAC Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit StumbleUpon Twitter current issue AAC About AAC Subscribers Authors Reviewers Advertisers Inquiries from the Press Permissions & Commercial Reprints ASM Journals Public Access Policy AAC RSS Feeds 1752 N Street N.W. • Washington DC 20036 202.737.3600 • 202.942.9355 fax • journals@asmusa.org Print ISSN: 0066-4804 Online ISSN: 1098-6596 Copyright © 2014 by the American Society for Microbiology.   For an alternate route to AAC .asm.org, visit: AAC       
ABSTRACT We developed a murine model of systemic sporotrichosis by using three strains of each of the two commonest species causing sporotrichosis, i.e., Sporothrix schenckii sensu stricto and Sporothrix brasiliensis , in order to evaluate the efficacy of posaconazole (PSC). The drug was administered at a dose of 2.5 or 5 mg/kg of body weight twice a day by gavage, and one group was treated with amphotericin B (AMB) as a control treatment. Posaconazole, especially at 5 mg/kg, showed good efficacy against all the strains tested, regardless of their MICs, as measured by prolonged survival, tissue burden reduction, and histopathology.
Author Josep Guarro
Fabiola Fernández-Silva
Emilio Mayayo
Javier Capilla
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Cites_doi 10.1128/AAC.01012-07
10.1128/JCM.00808-07
10.1016/j.diagmicrobio.2006.11.002
10.1016/S1286-4579(03)00181-3
10.1002/mus.20830
10.1128/AAC.00736-10
10.1016/j.jinf.2004.07.001
10.1128/AAC.01463-09
10.1086/520190
10.1111/j.1439-0507.2008.01655.x
10.1128/jcm.30.4.951-954.1992
10.1016/S1130-1406(07)70035-9
10.1111/j.1469-0691.2009.02824.x
10.1086/522765
10.1086/516356
10.1016/0002-9343(80)90120-5
10.1080/13693780701742399
10.1099/jmm.0.007609-0
10.1128/AAC.32.11.1619
10.1128/AAC.00172-10
10.1111/j.1439-0507.2009.01701.x
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Copyright © 2012, American Society for Microbiology. All Rights Reserved. 2012 American Society for Microbiology
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Issue 5
Keywords Mycosis
Azole derivatives
Treatment efficiency
Rodentia
Sporotrichosis
Infection
Vertebrata
Antifungal agent
Mammalia
Mouse
Animal
Triazole derivatives
Posaconazole
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References 19624508 - Clin Microbiol Infect. 2009 Jul;15(7):651-5
19019165 - Mycoses. 2010 Jan;53(1):78-80
16230207 - J Infect. 2005 Oct;51(3):e73-7
19679687 - J Med Microbiol. 2009 Dec;58(Pt 12):1607-10
2855294 - Antimicrob Agents Chemother. 1988 Nov;32(11):1619-23
1572983 - J Clin Microbiol. 1992 Apr;30(4):951-4
20145077 - Antimicrob Agents Chemother. 2010 May;54(5):1665-9
7361812 - Am J Med. 1980 Mar;68(3):455-7
21115792 - Antimicrob Agents Chemother. 2011 Feb;55(2):676-9
18324493 - Med Mycol. 2008 Mar;46(2):141-51
9636870 - Clin Infect Dis. 1998 Jun;26(6):1403-6
17968818 - Clin Infect Dis. 2007 Nov 15;45(10):1255-65
20930700 - G Ital Dermatol Venereol. 2010 Oct;145(5):659-73
17498572 - Diagn Microbiol Infect Dis. 2007 May;58(1):117-20
17623855 - Muscle Nerve. 2007 Dec;36(6):866-72
17604439 - Rev Iberoam Micol. 2007 Jun;24(2):161-3
12941384 - Microbes Infect. 2003 Sep;5(11):933-8
18528606 - Rev Port Pneumol. 2008 May-Jun;14(3):443-9
20625150 - Antimicrob Agents Chemother. 2010 Oct;54(10):4074-7
10476718 - Clin Infect Dis. 1999 Aug;29(2):231-6; quiz 237
17687013 - J Clin Microbiol. 2007 Oct;45(10):3198-206
18039919 - Antimicrob Agents Chemother. 2008 Feb;52(2):732-4
19389067 - Mycoses. 2010 May;53(3):227-31
Kohler, LM, Hamdan, JS, Ferrari, TC (B19) 2007; 58
Al-Tawfiq, JA, Wools, KK (B1) 1998; 26
Salas, VFJ, Rodríguez, MM, Calvo, E, Mayayo, E, Guarro, J (B24) 2011; 55
Arrillaga-Moncrieff, I (B2) 2009; 15
Vilela, R, Souza, GF, Fernandes Cota, G, Mendoza, L (B26) 2007; 24
(B8) 2008
Barroso Pereira, JC (B3) 2008; 14
Kauffman, CA, Bustamante, B, Chapman, SW, Pappas, PG (B18) 2007; 45
de Lima, RF, Schäffer, GV, Borba Cde, M (B9) 2003; 5
Mauermann, ML, Klein, CJ, Orenstein, R, Dyck, PJ (B22) 2007; 36
Gutierrez-Galhardo, MC (B13) 2010; 53
Hardman, S, Stephenson, I, Jenkins, DR, Wiselka, MJ, Johnson, EM (B15) 2005; 51
Gutierrez-Galhardo, MC, Zancope-Oliveira, RM, Monzon, A, Rodriguez-Tudela, JL, Cuenca-Estrella, M (B14) 2010; 53
Ewing, GE, Bosl, GJ, Peterson, PK (B11) 1980; 68
Dixon, DM, Duncan, RA, Hurd, NJ (B10) 1992; 30
Kauffman, CA (B17) 1999; 29
Calvo, E, Pastor, FJ, Rodríguez, MM, Pujol, I, Guarro, J (B7) 2010; 54
B4
Bonifaz, A, Vazquez-Gonzalez, D (B5) 2010; 145
B6
Marimon, R (B20) 2007; 45
Rodríguez, MM (B23) 2010; 54
Marimón, R (B21) 2008; 52
Silveira, CP (B25) 2009; 58
Kan, VL, Bennett, JE (B16) 1988; 32
Galhardo, MC (B12) 2008; 46
e_1_3_1_21_2
e_1_3_1_22_2
Bonifaz A (e_1_3_1_6_2) 2010; 145
e_1_3_1_24_2
e_1_3_1_8_2
Mauermann ML (e_1_3_1_23_2) 2007; 36
e_1_3_1_7_2
Ewing GE (e_1_3_1_12_2) 1980; 68
e_1_3_1_20_2
e_1_3_1_3_2
e_1_3_1_5_2
Hardman S (e_1_3_1_16_2) 2005; 51
e_1_3_1_25_2
e_1_3_1_26_2
e_1_3_1_2_2
e_1_3_1_27_2
Clinical and Laboratory Standards Institute (e_1_3_1_9_2) 2008
Galhardo MC (e_1_3_1_13_2) 2008; 46
de Lima RF (e_1_3_1_10_2) 2003; 5
e_1_3_1_11_2
e_1_3_1_17_2
e_1_3_1_15_2
e_1_3_1_14_2
e_1_3_1_19_2
Barroso Pereira JC (e_1_3_1_4_2) 2008; 14
e_1_3_1_18_2
References_xml – volume: 46
  start-page: 141
  year: 2008
  end-page: 151
  ident: B12
  article-title: Molecular epidemiology and antifungal susceptibility patterns of Sporothrix schenckii isolates from a cat-transmitted epidemic of sporotrichosis in Rio de Janeiro, Brazil
  publication-title: Med. Mycol.
  contributor:
    fullname: Galhardo, MC
– volume: 14
  start-page: 443
  year: 2008
  end-page: 449
  ident: B3
  article-title: Disseminated sporotrichosis—clinical case and discussion
  publication-title: Rev. Port. Pneumol.
  contributor:
    fullname: Barroso Pereira, JC
– volume: 30
  start-page: 951
  year: 1992
  end-page: 954
  ident: B10
  article-title: Use of a mouse model to evaluate clinical and environmental isolates of Sporothrix spp. from the largest U.S. epidemic of sporotrichosis
  publication-title: J. Clin. Microbiol.
  contributor:
    fullname: Hurd, NJ
– ident: B6
  article-title: Reference deleted .
– volume: 58
  start-page: 117
  year: 2007
  end-page: 120
  ident: B19
  article-title: Successful treatment of a disseminated Sporothrix schenckii infection and in vitro analysis for antifungal susceptibility testing
  publication-title: Diagn. Microbiol. Infect. Dis.
  contributor:
    fullname: Ferrari, TC
– volume: 68
  start-page: 455
  year: 1980
  end-page: 457
  ident: B11
  article-title: Sporothrix schenckii meningitis in a farmer with Hodgkin's disease
  publication-title: Am. J. Med.
  contributor:
    fullname: Peterson, PK
– volume: 54
  start-page: 4074
  year: 2010
  end-page: 4077
  ident: B7
  article-title: Antifungal therapy in a murine model of disseminated infection by Cryptococcus gattii
  publication-title: Antimicrob. Agents Chemother.
  contributor:
    fullname: Guarro, J
– volume: 55
  start-page: 676
  year: 2011
  end-page: 679
  ident: B24
  article-title: In vitro activity and in vivo efficacy of posaconazole in treatment of murine infections by different isolates of the Aspergillus terreus complex
  publication-title: Antimicrob. Agents Chemother.
  contributor:
    fullname: Guarro, J
– year: 2008
  ident: B8
  article-title: Reference method for broth dilution antifungal susceptibility testing of filamentous fungi
  publication-title: Approved standard—second edition ;Document M38-A2 ;CLSI ;Wayne, PA
– volume: 32
  start-page: 1619
  year: 1988
  end-page: 1623
  ident: B16
  article-title: Efficacies of four antifungal agents in experimental murine sporotrichosis
  publication-title: Antimicrob. Agents Chemother.
  contributor:
    fullname: Bennett, JE
– volume: 15
  start-page: 651
  year: 2009
  end-page: 655
  ident: B2
  article-title: Different virulence levels of the species of Sporothrix in a murine model
  publication-title: Clin. Microbiol. Infect.
  contributor:
    fullname: Arrillaga-Moncrieff, I
– ident: B4
  article-title: Reference deleted .
– volume: 26
  start-page: 1403
  year: 1998
  end-page: 1406
  ident: B1
  article-title: Disseminated sporotrichosis and Sporothrix schenckii fungemia as the initial presentation of human immunodeficiency virus infection
  publication-title: Clin. Infect. Dis.
  contributor:
    fullname: Wools, KK
– volume: 51
  start-page: 73
  year: 2005
  end-page: 77
  ident: B15
  article-title: Disseminated Sporothrix schenckii in a patient with AIDS
  publication-title: J. Infect.
  contributor:
    fullname: Johnson, EM
– volume: 45
  start-page: 1255
  year: 2007
  end-page: 1265
  ident: B18
  article-title: Clinical practice guidelines for the management of sporotrichosis: 2007 update by the Infectious Diseases Society of America
  publication-title: Clin. Infect. Dis.
  contributor:
    fullname: Pappas, PG
– volume: 24
  start-page: 161
  year: 2007
  end-page: 163
  ident: B26
  article-title: Cutaneous and meningeal sporotrichosis in a HIV patient
  publication-title: Rev. Iberoam. Micol.
  contributor:
    fullname: Mendoza, L
– volume: 29
  start-page: 231
  year: 1999
  end-page: 236
  ident: B17
  article-title: Sporotrichosis
  publication-title: Clin. Infect. Dis.
  contributor:
    fullname: Kauffman, CA
– volume: 36
  start-page: 866
  year: 2007
  end-page: 872
  ident: B22
  article-title: Disseminated sporotrichosis presenting with granulomatous inflammatory multiple mononeuropathies
  publication-title: Muscle Nerve
  contributor:
    fullname: Dyck, PJ
– volume: 53
  start-page: 78
  year: 2010
  end-page: 80
  ident: B13
  article-title: Disseminated sporotrichosis as a manifestation of immune reconstitution inflammatory syndrome
  publication-title: Mycoses
  contributor:
    fullname: Gutierrez-Galhardo, MC
– volume: 58
  start-page: 1607
  year: 2009
  end-page: 1610
  ident: B25
  article-title: MICs and minimum fungicidal concentrations of amphotericin B, itraconazole, posaconazole and terbinafine in Sporothrix schenckii
  publication-title: J. Med. Microbiol.
  contributor:
    fullname: Silveira, CP
– volume: 52
  start-page: 732
  year: 2008
  end-page: 734
  ident: B21
  article-title: In vitro antifungal susceptibilities of five species of Sporothrix
  publication-title: Antimicrob. Agents Chemother.
  contributor:
    fullname: Marimón, R
– volume: 54
  start-page: 1665
  year: 2010
  end-page: 1669
  ident: B23
  article-title: Correlation between in vitro activity of posaconazole and in vivo efficacy against Rhizopus oryzae infection in mice
  publication-title: Antimicrob. Agents Chemother.
  contributor:
    fullname: Rodríguez, MM
– volume: 45
  start-page: 3198
  year: 2007
  end-page: 3206
  ident: B20
  article-title: Sporothrix brasiliensis, S. globosa, and S. mexicana, three new Sporothrix species of clinical interest
  publication-title: J. Clin. Microbiol.
  contributor:
    fullname: Marimon, R
– volume: 53
  start-page: 227
  year: 2010
  end-page: 231
  ident: B14
  article-title: Antifungal susceptibility profile in vitro of Sporothrix schenckii in two growth phases and by two methods: microdilution and E-test
  publication-title: Mycoses
  contributor:
    fullname: Cuenca-Estrella, M
– volume: 145
  start-page: 659
  year: 2010
  end-page: 673
  ident: B5
  article-title: Sporotrichosis: an update
  publication-title: G. Ital. Dermatol. Venereol.
  contributor:
    fullname: Vazquez-Gonzalez, D
– volume: 5
  start-page: 933
  year: 2003
  end-page: 938
  ident: B9
  article-title: Variants of Sporothrix schenckii with attenuated virulence for mice
  publication-title: Microbes Infect.
  contributor:
    fullname: Borba Cde, M
– ident: e_1_3_1_22_2
  doi: 10.1128/AAC.01012-07
– ident: e_1_3_1_21_2
  doi: 10.1128/JCM.00808-07
– ident: e_1_3_1_20_2
  doi: 10.1016/j.diagmicrobio.2006.11.002
– volume: 5
  start-page: 933
  year: 2003
  ident: e_1_3_1_10_2
  article-title: Variants of Sporothrix schenckii with attenuated virulence for mice
  publication-title: Microbes Infect.
  doi: 10.1016/S1286-4579(03)00181-3
  contributor:
    fullname: de Lima RF
– volume: 36
  start-page: 866
  year: 2007
  ident: e_1_3_1_23_2
  article-title: Disseminated sporotrichosis presenting with granulomatous inflammatory multiple mononeuropathies
  publication-title: Muscle Nerve
  doi: 10.1002/mus.20830
  contributor:
    fullname: Mauermann ML
– ident: e_1_3_1_25_2
  doi: 10.1128/AAC.00736-10
– volume: 51
  start-page: 73
  year: 2005
  ident: e_1_3_1_16_2
  article-title: Disseminated Sporothrix schenckii in a patient with AIDS
  publication-title: J. Infect.
  doi: 10.1016/j.jinf.2004.07.001
  contributor:
    fullname: Hardman S
– ident: e_1_3_1_24_2
  doi: 10.1128/AAC.01463-09
– volume: 145
  start-page: 659
  year: 2010
  ident: e_1_3_1_6_2
  article-title: Sporotrichosis: an update
  publication-title: G. Ital. Dermatol. Venereol.
  contributor:
    fullname: Bonifaz A
– ident: e_1_3_1_18_2
  doi: 10.1086/520190
– ident: e_1_3_1_7_2
– ident: e_1_3_1_14_2
  doi: 10.1111/j.1439-0507.2008.01655.x
– ident: e_1_3_1_11_2
  doi: 10.1128/jcm.30.4.951-954.1992
– ident: e_1_3_1_5_2
– ident: e_1_3_1_27_2
  doi: 10.1016/S1130-1406(07)70035-9
– volume-title: Approved standard—second edition
  year: 2008
  ident: e_1_3_1_9_2
  contributor:
    fullname: Clinical and Laboratory Standards Institute
– ident: e_1_3_1_3_2
  doi: 10.1111/j.1469-0691.2009.02824.x
– ident: e_1_3_1_19_2
  doi: 10.1086/522765
– ident: e_1_3_1_2_2
  doi: 10.1086/516356
– volume: 68
  start-page: 455
  year: 1980
  ident: e_1_3_1_12_2
  article-title: Sporothrix schenckii meningitis in a farmer with Hodgkin's disease
  publication-title: Am. J. Med.
  doi: 10.1016/0002-9343(80)90120-5
  contributor:
    fullname: Ewing GE
– volume: 46
  start-page: 141
  year: 2008
  ident: e_1_3_1_13_2
  article-title: Molecular epidemiology and antifungal susceptibility patterns of Sporothrix schenckii isolates from a cat-transmitted epidemic of sporotrichosis in Rio de Janeiro, Brazil
  publication-title: Med. Mycol.
  doi: 10.1080/13693780701742399
  contributor:
    fullname: Galhardo MC
– ident: e_1_3_1_26_2
  doi: 10.1099/jmm.0.007609-0
– ident: e_1_3_1_17_2
  doi: 10.1128/AAC.32.11.1619
– ident: e_1_3_1_8_2
  doi: 10.1128/AAC.00172-10
– volume: 14
  start-page: 443
  year: 2008
  ident: e_1_3_1_4_2
  article-title: Disseminated sporotrichosis—clinical case and discussion
  publication-title: Rev. Port. Pneumol.
  contributor:
    fullname: Barroso Pereira JC
– ident: e_1_3_1_15_2
  doi: 10.1111/j.1439-0507.2009.01701.x
SSID ssj0006590
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Snippet Classifications Services AAC Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit...
We developed a murine model of systemic sporotrichosis by using three strains of each of the two commonest species causing sporotrichosis, i.e., Sporothrix...
ABSTRACT We developed a murine model of systemic sporotrichosis by using three strains of each of the two commonest species causing sporotrichosis, i.e.,...
We developed a murine model of systemic sporotrichosis by using three strains of each of the two commonest species causing sporotrichosis, i.e., Sporothrix...
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SubjectTerms Administration, Oral
Amphotericin B
Amphotericin B - administration & dosage
Amphotericin B - therapeutic use
Animal models
Animals
Antibiotics. Antiinfectious agents. Antiparasitic agents
Antifungal Agents
Antifungal Agents - administration & dosage
Antifungal Agents - therapeutic use
Biological and medical sciences
Body weight
Disease Models, Animal
Dose-Response Relationship, Drug
Drug Administration Schedule
Drugs
Experimental Therapeutics
Histocytochemistry
Human mycoses
Infectious diseases
Liver
Liver - drug effects
Liver - microbiology
Male
Medical sciences
Mice
Microbial Sensitivity Tests
Minimum inhibitory concentration
Mycoses
Pharmacology. Drug treatments
Posaconazole
Species Specificity
Sporothrix
Sporothrix - drug effects
Sporothrix - physiology
Sporothrix schenckii
Sporotrichosis
Sporotrichosis - drug therapy
Sporotrichosis - microbiology
Sporotrichosis - mortality
Sporotrichosis - pathology
Survival
Survival Rate
Treatment Outcome
Triazoles
Triazoles - administration & dosage
Triazoles - therapeutic use
Tropical mycoses
Title Efficacy of Posaconazole in Murine Experimental Sporotrichosis
URI http://aac.asm.org/content/56/5/2273.abstract
https://www.ncbi.nlm.nih.gov/pubmed/22330929
https://journals.asm.org/doi/10.1128/AAC.05376-11
https://search.proquest.com/docview/1017978120
https://search.proquest.com/docview/1017981441
https://pubmed.ncbi.nlm.nih.gov/PMC3346655
Volume 56
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