Neural Correlates of Stress-Induced and Cue-Induced Drug Craving: Influences of Sex and Cocaine Dependence

• Published in: American Journal of Psychiatry Vol. 169; no. 4; pp. 406 - 414
• Main Authors: Potenza, Marc N, Hong, Kwang-ik Adam, Lacadie, Cheryl M, Fulbright, Robert K, Tuit, Keri L, Sinha, Rajita
• Format: Journal Article
• Language: English
• Published: Arlington, VA American Psychiatric Publishing 01.04.2012; American Psychiatric Association
• Subjects: Addictive behaviors; Adult; Adult and adolescent clinical studies; Anxiety - physiopathology; Anxiety - psychology; Behavior, Addictive - physiopathology; Behavior, Addictive - psychology; Biological and medical sciences; Brain - physiopathology; Cocaine; Cocaine-Related Disorders - physiopathology; Cocaine-Related Disorders - psychology; Cues; Drug addiction; Female; Functional Neuroimaging - methods; Functional Neuroimaging - psychology; Gender differences; Heart Rate - physiology; Humans; Magnetic Resonance Imaging - methods; Magnetic Resonance Imaging - psychology; Male; Medical sciences; Neural Pathways - physiopathology; Neuropsychology; Psychology. Psychoanalysis. Psychiatry; Psychopathology; Psychopathology. Psychiatry; Psychotherapy; Relaxation - physiology; Relaxation - psychology; Sex Characteristics; Stress; Stress, Psychological - physiopathology; Stress, Psychological - psychology; Ester; Drug addiction; Craving; Dependence; Sex; Cocaine; Drug of abuse; Stress

Activity in brain regions linked to substance abuse was greater in cocaine-dependent women than in non-substance-abusing women after stress but not after exposure to drug-related cues. For men with cocaine dependence, the pattern was reversed: more widespread hyperactivation after drug-related cues...