PXR Variants and Artemisinin Use in Vietnamese Subjects: Frequency Distribution and Impact on the Interindividual Variability of CYP3A Induction by Artemisinin

• Published in: Antimicrobial Agents and Chemotherapy Vol. 56; no. 4; pp. 2153 - 2157
• Main Authors: Piedade, Rita, Schaeffeler, Elke, Winter, Stefan, Asimus, Sara, Schwab, Matthias, Ashton, Michael, Burk, Oliver, Gil, José P.
• Format: Journal Article
• Language: English
• Published: Washington, DC American Society for Microbiology 01.04.2012
• Subjects: 3' Untranslated Regions; 3' Untranslated Regions - genetics; Alleles; Antibiotics. Antiinfectious agents. Antiparasitic agents; Antimalarials; Antimalarials - pharmacology; Artemisinins; Artemisinins - pharmacology; Biological and medical sciences; biosynthesis; Cytochrome P-450 CYP3A; Cytochrome P-450 CYP3A - biosynthesis; Cytochrome P-450 CYP3A - genetics; DNA Primers; drug effects; Enzyme Induction; Enzyme Induction - drug effects; epidemiology; Farmaceutiska vetenskaper; Gene Frequency; Genetic Variation; genetics; Humans; Mass; Matrix-Assisted Laser Desorption-Ionization; Medical sciences; metabolism; Pharmaceutical Preparations; Pharmaceutical Preparations - metabolism; Pharmaceutical Sciences; Pharmacology; Pharmacology. Drug treatments; Polymorphism; Polymorphism, Single Nucleotide; Receptors; Receptors, Steroid; Receptors, Steroid - drug effects; Receptors, Steroid - genetics; Single Nucleotide; Spectrometry; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Steroid; Vietnam; Vietnam - epidemiology; Vietnam; Human; Antimalarial; Genetic variability; Enzyme; Induction; Isozyme; Cytochrome P450; Pregnane X receptor; Artemisinin; Genotype; Variant; Interindividual comparison; Distribution; Parasiticide; Frequency; Vietnamese; Pharmacokinetics

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