Intermittent Fasting Modulation of the Diabetic Syndrome in Streptozotocin-Injected Rats
This study investigates the effects of intermittent overnight fasting in streptozotocin-induced diabetic rats (STZ rats). Over 30 days, groups of 5-6 control or STZ rats were allowed free food access, starved overnight, or exposed to a restricted food supply comparable to that ingested by the interm...
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| Published in | International Journal of Endocrinology Vol. 2012; no. 2012; pp. 999 - 1010 |
|---|---|
| Main Authors | , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
Cairo, Egypt
Hindawi Limiteds
01.01.2012
Hindawi Puplishing Corporation Hindawi Publishing Corporation Wiley |
| Online Access | Get full text |
| ISSN | 1687-8337 1687-8345 1687-8345 |
| DOI | 10.1155/2012/962012 |
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| Abstract | This study investigates the effects of intermittent overnight fasting in streptozotocin-induced diabetic rats (STZ rats). Over 30 days, groups of 5-6 control or STZ rats were allowed free food access, starved overnight, or exposed to a restricted food supply comparable to that ingested by the intermittently fasting animals. Intermittent fasting improved glucose tolerance, increased plasma insulin, and lowered Homeostatis Model Assessment index. Caloric restriction failed to cause such beneficial effects. The β-cell mass, as well as individual β-cell and islet area, was higher in intermittently fasting than in nonfasting STZ rats, whilst the percentage of apoptotic β-cells appeared lower in the former than latter STZ rats. In the calorie-restricted STZ rats, comparable findings were restricted to individual islet area and percentage of apoptotic cells. Hence, it is proposed that intermittent fasting could represent a possible approach to prevent or minimize disturbances of glucose homeostasis in human subjects. |
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| AbstractList | This study investigates the effects of intermittent overnight fasting in streptozotocin-induced diabetic rats (STZ rats). Over 30 days, groups of 5-6 control or STZ rats were allowed free food access, starved overnight, or exposed to a restricted food supply comparable to that ingested by the intermittently fasting animals. Intermittent fasting improved glucose tolerance, increased plasma insulin, and lowered Homeostatis Model Assessment index. Caloric restriction failed to cause such beneficial effects. The β-cell mass, as well as individual β-cell and islet area, was higher in intermittently fasting than in nonfasting STZ rats, whilst the percentage of apoptotic β-cells appeared lower in the former than latter STZ rats. In the calorie-restricted STZ rats, comparable findings were restricted to individual islet area and percentage of apoptotic cells. Hence, it is proposed that intermittent fasting could represent a possible approach to prevent or minimize disturbances of glucose homeostasis in human subjects. This study investigates the effects of intermittent overnight fasting in streptozotocin-induced diabetic rats (STZ rats). Over 30 days, groups of 5-6 control or STZ rats were allowed free food access, starved overnight, or exposed to a restricted food supply comparable to that ingested by the intermittently fasting animals. Intermittent fasting improved glucose tolerance, increased plasma insulin, and lowered Homeostatis Model Assessment index. Caloric restriction failed to cause such beneficial effects. The β -cell mass, as well as individual β -cell and islet area, was higher in intermittently fasting than in nonfasting STZ rats, whilst the percentage of apoptotic β -cells appeared lower in the former than latter STZ rats. In the calorie-restricted STZ rats, comparable findings were restricted to individual islet area and percentage of apoptotic cells. Hence, it is proposed that intermittent fasting could represent a possible approach to prevent or minimize disturbances of glucose homeostasis in human subjects. This study investigates the effects of intermittent overnight fasting in streptozotocin-induced diabetic rats (STZ rats). Over 30 days, groups of 5-6 control or STZ rats were allowed free food access, starved overnight, or exposed to a restricted food supply comparable to that ingested by the intermittently fasting animals. Intermittent fasting improved glucose tolerance, increased plasma insulin, and lowered Homeostatis Model Assessment index. Caloric restriction failed to cause such beneficial effects. The β-cell mass, as well as individual β-cell and islet area, was higher in intermittently fasting than in nonfasting STZ rats, whilst the percentage of apoptotic β-cells appeared lower in the former than latter STZ rats. In the calorie-restricted STZ rats, comparable findings were restricted to individual islet area and percentage of apoptotic cells. Hence, it is proposed that intermittent fasting could represent a possible approach to prevent or minimize disturbances of glucose homeostasis in human subjects.This study investigates the effects of intermittent overnight fasting in streptozotocin-induced diabetic rats (STZ rats). Over 30 days, groups of 5-6 control or STZ rats were allowed free food access, starved overnight, or exposed to a restricted food supply comparable to that ingested by the intermittently fasting animals. Intermittent fasting improved glucose tolerance, increased plasma insulin, and lowered Homeostatis Model Assessment index. Caloric restriction failed to cause such beneficial effects. The β-cell mass, as well as individual β-cell and islet area, was higher in intermittently fasting than in nonfasting STZ rats, whilst the percentage of apoptotic β-cells appeared lower in the former than latter STZ rats. In the calorie-restricted STZ rats, comparable findings were restricted to individual islet area and percentage of apoptotic cells. Hence, it is proposed that intermittent fasting could represent a possible approach to prevent or minimize disturbances of glucose homeostasis in human subjects. |
| Author | Hupkens, Emeline Sener, Abdullah Malaisse, Willy J. Belkacemi, Louiza Louchami, Karim Selselet-Attou, Ghalem Nguidjoe, Evrard |
| AuthorAffiliation | 2 Laboratory of Experimental Hormonology, Université Libre de Bruxelles, 808 Route de Lennik, 1070 Brussels, Belgium 1 Laboratoire de Technologie Alimentaire et Nutrition, Université de Mostaganem, 1070 Mostaganem, Algeria 3 Laboratory of Pharmacology, Université Libre de Bruxelles, 808 Route de Lennik, 1070 Brussels, Belgium |
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| Author_xml | – sequence: 1 givenname: Louiza surname: Belkacemi fullname: Belkacemi, Louiza organization: Laboratoire de Technologie Alimentaire et NutritionUniversité de Mostaganem1070 MostaganemAlgeriauniv-mosta.dz – sequence: 2 givenname: Ghalem surname: Selselet-Attou fullname: Selselet-Attou, Ghalem organization: Laboratoire de Technologie Alimentaire et NutritionUniversité de Mostaganem1070 MostaganemAlgeriauniv-mosta.dz – sequence: 3 givenname: Emeline surname: Hupkens fullname: Hupkens, Emeline organization: Laboratory of Experimental HormonologyUniversité Libre de Bruxelles808 Route de Lennik1070 BrusselsBelgiumulb.ac.be – sequence: 4 givenname: Evrard surname: Nguidjoe fullname: Nguidjoe, Evrard organization: Laboratory of PharmacologyUniversité Libre de Bruxelles808 Route de Lennik1070 BrusselsBelgiumulb.ac.be – sequence: 5 givenname: Karim surname: Louchami fullname: Louchami, Karim organization: Laboratory of Experimental HormonologyUniversité Libre de Bruxelles808 Route de Lennik1070 BrusselsBelgiumulb.ac.be – sequence: 6 givenname: Abdullah surname: Sener fullname: Sener, Abdullah organization: Laboratory of Experimental HormonologyUniversité Libre de Bruxelles808 Route de Lennik1070 BrusselsBelgiumulb.ac.be – sequence: 7 givenname: Willy J. surname: Malaisse fullname: Malaisse, Willy J. organization: Laboratory of Experimental HormonologyUniversité Libre de Bruxelles808 Route de Lennik1070 BrusselsBelgiumulb.ac.be |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/22291702$$D View this record in MEDLINE/PubMed |
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| ContentType | Journal Article |
| Contributor | Hupkens, Emeline Sener, Abdullah Malaisse, Willy J Belkacemi, Louiza Louchami, Karim Selselet-Attou, Ghalem Nguidjoe, Evrard |
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| Copyright | Copyright © 2012 Louiza Belkacemi et al. Copyright © 2012 Louiza Belkacemi et al. 2012 |
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| Title | Intermittent Fasting Modulation of the Diabetic Syndrome in Streptozotocin-Injected Rats |
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