Nosocomial spread of cephem-resistant Escherichia coli strains carrying multiple Toho-1-like beta-lactamase genes
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| Published in | Antimicrobial Agents and Chemotherapy Vol. 41; no. 12; pp. 2606 - 2611 |
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| Main Authors | , , , , , , , , , , |
| Format | Journal Article |
| Language | English |
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Washington, DC
American Society for Microbiology
01.12.1997
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| AbstractList | Escherichia coli HKY56, which demonstrated resistance to various beta-lactams except carbapenems, was isolated from the throat swab of an inpatient in 1994. Conjugal transfer of cephem resistance from HKY56 to E. coli CSH2 was not successful. Three cefotaxime-resistant E. coli clones harboring plasmid pMRE001, pMRE002, or pMRE003, each of which carried a 3.4-, 5.8-, or 6.2-kb EcoRI fragment insert, respectively, were obtained from HKY56. Although restriction analysis suggested their different origins, these clones showed similar profiles of resistance to various beta-lactams. The sequence of 10 amino acid residues at the N terminus of beta-lactamase purified from E. coli HB101(pMRE001) was identical to that of Toho-1. This Toho-1-like beta-lactamase-1 (TLB-1) was able to hydrolyze cefoperazone and cefotaxime efficiently, but it failed to hydrolyze cephamycins. A Toho-1-specific DNA probe was hybridized with three distinct EcoRI fragments derived from the chromosomal DNA of strain HKY56, and these fragments corresponded to DNA inserts carried by pMRE001, pMRE002, and pMRE003, respectively. PCR and Southern hybridization analysis suggested that all six cephem-resistant E. coli strains, strains HKY273, HKY285, HKY288, HKY305, HKY316, and HKY335, which were isolated in 1996 at the same hospital where strain HKY56 had been isolated, also possessed multiple Toho-1-like beta-lactamase (TLB) genes, and the hybridization patterns obtained with the Toho-1-specific probe were quite similar among these six isolates. The DNA fingerprinting patterns observed by pulsed-field gel electrophoresis revealed that among the E. coli isolates tested, all isolates except HKY56 possessed a similar genetic background. These findings suggested that E. coli strains that carry chromosomally multiplied TLB genes may have been proliferating and transmitted among patients in the same hospital. Services AAC Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit StumbleUpon Twitter current issue AAC About AAC Subscribers Authors Reviewers Advertisers Inquiries from the Press Permissions & Commercial Reprints ASM Journals Public Access Policy AAC RSS Feeds 1752 N Street N.W. • Washington DC 20036 202.737.3600 • 202.942.9355 fax • journals@asmusa.org Print ISSN: 0066-4804 Online ISSN: 1098-6596 Copyright © 2014 by the American Society for Microbiology. For an alternate route to AAC .asm.org, visit: AAC |
| Author | S Ichiyama K Shimokata H Kurokawa N Kato M Ohta T Yagi S Ohsuka H Ito K Senda K Shibayama Y Arakawa |
| AuthorAffiliation | Department of Bacteriology, Nagoya University School of Medicine, Japan |
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| Keywords | Molecular hybridization Cefoperazone Cefotaxime Enzyme Escherichia coli β-Lactams β-Lactamase In vitro Genetic transfer Cephalosporin derivatives Microorganism resistance Microorganism culture Bacteria Hydrolases Molecular cloning Aminoacid sequence Enterobacteriaceae |
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StumbleUpon... Escherichia coli HKY56, which demonstrated resistance to various beta-lactams except carbapenems, was isolated from the throat swab of an inpatient in 1994.... Escherichia coli HKY56, which demonstrated resistance to various beta -lactams except carbapenems, was isolated from the throat swab of an inpatient in 1994.... |
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| SubjectTerms | Antibiotics. Antiinfectious agents. Antiparasitic agents Bacteriology beta-Lactam Resistance beta-Lactam Resistance - genetics beta-Lactamases beta-Lactamases - genetics beta-Lactamases - isolation & purification Biological and medical sciences Carbapenems Carbapenems - pharmacology Cloning, Molecular Conjugation, Genetic - genetics Cross Infection Cross Infection - genetics Cross Infection - microbiology Escherichia coli Escherichia coli - drug effects Escherichia coli - genetics Fundamental and applied biological sciences. Psychology Gene Transfer Techniques General aspects Isoelectric Focusing Kinetics Medical sciences Metabolism. Enzymes Microbiology Pharmacology. Drug treatments Research Support, Non-U.S. Gov't |
| Title | Nosocomial spread of cephem-resistant Escherichia coli strains carrying multiple Toho-1-like beta-lactamase genes |
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