Real-Time Sequencing To Decipher the Molecular Mechanism of Resistance of a Clinical Pan-Drug-Resistant Acinetobacter baumannii Isolate from Marseille, France

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Published inAntimicrobial Agents and Chemotherapy Vol. 57; no. 1; pp. 592 - 596
Main Authors Rolain, Jean-Marc, Diene, Seydina M., Kempf, Marie, Gimenez, Gregory, Robert, Catherine, Raoult, Didier
Format Journal Article
LanguageEnglish
Published Washington, DC American Society for Microbiology 01.01.2013
Subjects
Acinetobacter baumannii
Acinetobacter baumannii - drug effects
Acinetobacter baumannii - genetics
Acinetobacter baumannii - isolation & purification
Acinetobacter Infections - drug therapy
Acinetobacter Infections - microbiology
Anti-Bacterial Agents
Anti-Bacterial Agents - pharmacology
Anti-Bacterial Agents - therapeutic use
Antibiotics. Antiinfectious agents. Antiparasitic agents
Bacterial Proteins
Bacterial Proteins - genetics
Bacterial Typing Techniques
Biological and medical sciences
Chromosomes, Bacterial
Colistin
Colistin - pharmacology
Colistin - therapeutic use
Drug Resistance, Multiple, Bacterial
Drug Resistance, Multiple, Bacterial - genetics
France
High-Throughput Nucleotide Sequencing
Humans
Life Sciences
Mechanisms of Resistance
Medical sciences
Pharmacology. Drug treatments
Rifampin
Rifampin - pharmacology
Rifampin - therapeutic use
Sequence Analysis, DNA
Transcription Factors
Transcription Factors - genetics
France
Europe
Acinetobacter baumannii
Nucleotide sequence
Multiple resistance
Neisseriaceae
Bacteria
Micrococcales
Isolate
Mechanism of action
Real time
Sequencing
Bacterial
Acinetobacter Infections
Multiple
Colistin
Humans
Bacterial Proteins
Anti-Bacterial Agents
Bacterial Typing Techniques
DNA
High-Throughput Nucleotide Sequencing
Transcription Factors
Sequence Analysis
France
Chromosomes
Rifampin
Drug Resistance
Online AccessGet full text

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Abstract Classifications Services AAC Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit StumbleUpon Twitter current issue AAC About AAC Subscribers Authors Reviewers Advertisers Inquiries from the Press Permissions & Commercial Reprints ASM Journals Public Access Policy AAC RSS Feeds 1752 N Street N.W. • Washington DC 20036 202.737.3600 • 202.942.9355 fax • journals@asmusa.org Print ISSN: 0066-4804 Online ISSN: 1098-6596 Copyright © 2014 by the American Society for Microbiology.   For an alternate route to AAC .asm.org, visit: AAC       
AbstractList We compare the whole-genome sequences of two multidrug-resistant clinical Acinetobacter baumannii isolates recovered in the same patient before (ABIsac_ColiS susceptible to colistin and rifampin only) and after (ABIsac_ColiR resistant to colistin and rifampin) treatment with colistin and rifampin. We decipher all the molecular mechanisms of antibiotic resistance, and we found mutations in the rpoB gene and in the PmrAB two-component system explaining resistance to rifampin and colistin in ABIsac_ColiR, respectively.We compare the whole-genome sequences of two multidrug-resistant clinical Acinetobacter baumannii isolates recovered in the same patient before (ABIsac_ColiS susceptible to colistin and rifampin only) and after (ABIsac_ColiR resistant to colistin and rifampin) treatment with colistin and rifampin. We decipher all the molecular mechanisms of antibiotic resistance, and we found mutations in the rpoB gene and in the PmrAB two-component system explaining resistance to rifampin and colistin in ABIsac_ColiR, respectively.
We compare the whole-genome sequences of two multidrug-resistant clinical Acinetobacter baumannii isolates recovered in the same patient before (ABIsac_ColiS susceptible to colistin and rifampin only) and after (ABIsac_ColiR resistant to colistin and rifampin) treatment with colistin and rifampin. We decipher all the molecular mechanisms of antibiotic resistance, and we found mutations in the rpoB gene and in the PmrAB two-component system explaining resistance to rifampin and colistin in ABIsac_ColiR, respectively.
We compare the whole-genome sequences of two multidrug-resistant clinical Acinetobacter baumannii isolates recovered in the same patient before (ABIsac_ColiS susceptible to colistin and rifampin only) and after (ABIsac_ColiR resistant to colistin and rifampin) treatment with colistin and rifampin. We decipher all the molecular mechanisms of antibiotic resistance, and we found mutations in the rpoB gene and in the PmrAB two-component system explaining resistance to rifampin and colistin in ABIsac_ColiR, respectively.
Classifications Services AAC Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit StumbleUpon Twitter current issue AAC About AAC Subscribers Authors Reviewers Advertisers Inquiries from the Press Permissions & Commercial Reprints ASM Journals Public Access Policy AAC RSS Feeds 1752 N Street N.W. • Washington DC 20036 202.737.3600 • 202.942.9355 fax • journals@asmusa.org Print ISSN: 0066-4804 Online ISSN: 1098-6596 Copyright © 2014 by the American Society for Microbiology.   For an alternate route to AAC .asm.org, visit: AAC       
Author Marie Kempf
Didier Raoult
Seydina M. Diene
Catherine Robert
Gregory Gimenez
Jean-Marc Rolain
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  surname: Rolain
  fullname: Rolain, Jean-Marc
  organization: Unité de Recherche sur les Maladies Infectieuses et Tropicales Emergents (URMITE), UMR CNRS-IRD-INSERM, IHU Méditerranée Infection, Aix-Marseille Université, Marseille, France
– sequence: 2
  givenname: Seydina M.
  surname: Diene
  fullname: Diene, Seydina M.
  organization: Unité de Recherche sur les Maladies Infectieuses et Tropicales Emergents (URMITE), UMR CNRS-IRD-INSERM, IHU Méditerranée Infection, Aix-Marseille Université, Marseille, France
– sequence: 3
  givenname: Marie
  surname: Kempf
  fullname: Kempf, Marie
  organization: Unité de Recherche sur les Maladies Infectieuses et Tropicales Emergents (URMITE), UMR CNRS-IRD-INSERM, IHU Méditerranée Infection, Aix-Marseille Université, Marseille, France
– sequence: 4
  givenname: Gregory
  surname: Gimenez
  fullname: Gimenez, Gregory
  organization: Unité de Recherche sur les Maladies Infectieuses et Tropicales Emergents (URMITE), UMR CNRS-IRD-INSERM, IHU Méditerranée Infection, Aix-Marseille Université, Marseille, France
– sequence: 5
  givenname: Catherine
  surname: Robert
  fullname: Robert, Catherine
  organization: Unité de Recherche sur les Maladies Infectieuses et Tropicales Emergents (URMITE), UMR CNRS-IRD-INSERM, IHU Méditerranée Infection, Aix-Marseille Université, Marseille, France
– sequence: 6
  givenname: Didier
  surname: Raoult
  fullname: Raoult, Didier
  organization: Unité de Recherche sur les Maladies Infectieuses et Tropicales Emergents (URMITE), UMR CNRS-IRD-INSERM, IHU Méditerranée Infection, Aix-Marseille Université, Marseille, France
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ContentType Journal Article
Copyright 2014 INIST-CNRS
Copyright © 2013, American Society for Microbiology. All Rights Reserved.
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Copyright © 2013, American Society for Microbiology. All Rights Reserved. 2013 American Society for Microbiology
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– notice: Copyright © 2013, American Society for Microbiology. All Rights Reserved.
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Issue 1
Keywords Acinetobacter baumannii
Nucleotide sequence
Multiple resistance
Neisseriaceae
Bacteria
Micrococcales
Isolate
Mechanism of action
Real time
Sequencing
Bacterial
Acinetobacter Infections
Multiple
Colistin
Humans
Bacterial Proteins
Anti-Bacterial Agents
Bacterial Typing Techniques
DNA
High-Throughput Nucleotide Sequencing
Transcription Factors
Sequence Analysis
France
Chromosomes
Rifampin
Drug Resistance
Language English
License CC BY 4.0
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PMCID: PMC3535948
J.-M.R. and S.M.D. contributed equally to this work.
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PublicationTitle Antimicrobial Agents and Chemotherapy
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We compare the whole-genome sequences of two multidrug-resistant clinical Acinetobacter baumannii isolates recovered in the same patient before (ABIsac_ColiS...
We compare the whole-genome sequences of two multidrug-resistant clinical Acinetobacter baumannii isolates recovered in the same patient before (ABIsac_ColiS...
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SubjectTerms Acinetobacter baumannii
Acinetobacter baumannii - drug effects
Acinetobacter baumannii - genetics
Acinetobacter baumannii - isolation & purification
Acinetobacter Infections - drug therapy
Acinetobacter Infections - microbiology
Anti-Bacterial Agents
Anti-Bacterial Agents - pharmacology
Anti-Bacterial Agents - therapeutic use
Antibiotics. Antiinfectious agents. Antiparasitic agents
Bacterial Proteins
Bacterial Proteins - genetics
Bacterial Typing Techniques
Biological and medical sciences
Chromosomes, Bacterial
Colistin
Colistin - pharmacology
Colistin - therapeutic use
Drug Resistance, Multiple, Bacterial
Drug Resistance, Multiple, Bacterial - genetics
France
High-Throughput Nucleotide Sequencing
Humans
Life Sciences
Mechanisms of Resistance
Medical sciences
Pharmacology. Drug treatments
Rifampin
Rifampin - pharmacology
Rifampin - therapeutic use
Sequence Analysis, DNA
Transcription Factors
Transcription Factors - genetics
Title Real-Time Sequencing To Decipher the Molecular Mechanism of Resistance of a Clinical Pan-Drug-Resistant Acinetobacter baumannii Isolate from Marseille, France
URI http://aac.asm.org/content/57/1/592.abstract
https://www.ncbi.nlm.nih.gov/pubmed/23070160
https://journals.asm.org/doi/10.1128/AAC.01314-12
https://www.proquest.com/docview/1273440455
https://hal.science/hal-01389302
https://pubmed.ncbi.nlm.nih.gov/PMC3535948
Volume 57
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