Protein Degradation by In-Cell Self-Assembly of Proteolysis Targeting Chimeras

• Published in: ACS central science Vol. 2; no. 12; pp. 927 - 934
• Main Authors: Lebraud, Honorine, Wright, David J, Johnson, Christopher N, Heightman, Tom D
• Format: Journal Article
• Language: English
• Published: United States American Chemical Society 28.12.2016

Selective degradation of proteins by proteolysis targeting chimeras (PROTACs) offers a promising potential alternative to protein inhibition for therapeutic intervention. Current PROTAC molecules incorporate a ligand for the target protein, a linker, and an E3 ubiquitin ligase recruiting group, whic...