Frontotemporal cerebral blood flow change during executive and declarative memory tasks in schizophrenia: a positron emission tomography study

• Published in: Neuropsychology Vol. 12; no. 3; p. 399
• Main Authors: Ragland, J D, Gur, R C, Glahn, D C, Censits, D M, Smith, R J, Lazarev, M G, Alavi, A, Gur, R E
• Format: Journal Article
• Language: English
• Published: United States 01.07.1998
• Subjects: Adult; Analysis of Variance; Attention - physiology; Brain Mapping; Case-Control Studies; Cerebrovascular Circulation - physiology; Cognition Disorders - diagnostic imaging; Cognition Disorders - physiopathology; Concept Formation - physiology; Female; Frontal Lobe - blood supply; Frontal Lobe - diagnostic imaging; Frontal Lobe - physiopathology; Humans; Inhibition (Psychology); Limbic System - blood supply; Limbic System - diagnostic imaging; Limbic System - physiopathology; Linear Models; Male; Memory - physiology; Memory Disorders - diagnostic imaging; Memory Disorders - physiopathology; Memory, Short-Term - physiology; Neuropsychological Tests; Schizophrenia - diagnostic imaging; Schizophrenia - physiopathology; Schizophrenic Psychology; Temporal Lobe - blood supply; Temporal Lobe - diagnostic imaging; Temporal Lobe - physiopathology; Tomography, Emission-Computed; Verbal Learning - physiology; Volition - physiology

Schizophrenia affects prefrontal and temporal-limbic networks. These regions were examined by contrasting regional cerebral blood flow (rCBF) during executive (Wisconsin Card Sorting Test [WCST]), and declarative memory tasks (Paired Associate Recognition Test [PART]). The tasks, and a resting basel...