Carbon Nanotubes Induce Malignant Transformation and Tumorigenesis of Human Lung Epithelial Cells

• Published in: Nano letters Vol. 11; no. 7; pp. 2796 - 2803
• Main Authors: Wang, Liying, Luanpitpong, Sudjit, Castranova, Vincent, Tse, William, Lu, Yongju, Pongrakhananon, Varisa, Rojanasakul, Yon
• Format: Journal Article
• Language: English
• Published: Washington, DC American Chemical Society 13.07.2011
• Subjects: Animals; Apoptosis; Carbon; Carbon nanotubes; Carcinogenicity; Cell Transformation, Neoplastic - metabolism; Cell Transformation, Neoplastic - pathology; Cross-disciplinary physics: materials science; rheology; Epithelial Cells - metabolism; Epithelial Cells - pathology; Exact sciences and technology; Human; Humans; Lung - metabolism; Lung - pathology; Lungs; Materials science; Mice; Mice, Nude; Nanocrystalline materials; Nanoscale materials and structures: fabrication and characterization; Nanostructure; Nanotechnology; Nanotubes; Nanotubes, Carbon - chemistry; Particle Size; Physics; Single wall carbon nanotubes; Surface Properties; Transformations; Tumor Suppressor Protein p53 - metabolism; lung; apoptosis; carcinogenesis; malignant transformation; Single-walled carbon nanotubes; Carbon nanotubes; Singlewalled nanotube; Tumor cells; Carbon; Nanostructured materials

Carcinogenicity of carbon nanotubes is a major concern but has not been well addressed due to the lack of experimental models. Here, we show that chronic exposure to single-walled carbon nanotubes causes malignant transformation of human lung epithelial cells. The transformed cells induce tumorigene...