Cortical Deficits of Glutamic Acid Decarboxylase 67 Expression in Schizophrenia: Clinical, Protein, and Cell Type-Specific Features

• Published in: The American journal of psychiatry Vol. 168; no. 9; pp. 921 - 929
• Main Authors: Curley, Allison A., Arion, Dominique, Volk, David W., Asafu-Adjei, Josephine K., Sampson, Allan R., Fish, Kenneth N., Lewis, David A.
• Format: Journal Article
• Language: English
• Published: Arlington, VA American Psychiatric Publishing 01.09.2011; American Psychiatric Association
• Subjects: Adult; Adult and adolescent clinical studies; Biological and medical sciences; Blotting, Western; Brain; Cognition & reasoning; Cognition Disorders - genetics; Cognition Disorders - pathology; Cohort Studies; Enzymes; Female; gamma-Aminobutyric Acid - metabolism; Gene expression; Glutamate Decarboxylase - genetics; Humans; Male; Medical sciences; Microscopy, Fluorescence; Middle Aged; Neurons - metabolism; Neurons - pathology; Neuropsychology; Parvalbumins - metabolism; Prefrontal Cortex - enzymology; Prefrontal Cortex - pathology; Presynaptic Terminals; Proteins; Psychology. Psychoanalysis. Psychiatry; Psychopathology. Psychiatry; Psychoses; Reference Values; RNA, Messenger - genetics; Schizophrenia; Schizophrenia - genetics; Schizophrenia - pathology; Psychosis; Carbon-carbon lyases; Enzyme; Carboxy-lyases; Schizophrenia; Lyases; Glutamate decarboxylase; Protein

Depression was associated with increased inflammation as measured by elevated levels of interleukin-6 and high-sensitivity C-reactive protein in patients with coronary heart disease, which was accounted for by the increased body mass index and cigarette smoking associated with depression. Objective:...