Viperin Reveals Its True Function

• Published in: Annual review of virology Vol. 7; no. 1; p. 421
• Main Authors: Rivera-Serrano, Efraín E, Gizzi, Anthony S, Arnold, Jamie J, Grove, Tyler L, Almo, Steven C, Cameron, Craig E
• Format: Journal Article
• Language: English
• Published: United States 29.09.2020
• Subjects: Cytidine Triphosphate - metabolism; Humans; Oxidoreductases Acting on CH-CH Group Donors; Proteins - chemistry; Proteins - genetics; Proteins - metabolism; RNA-Dependent RNA Polymerase - metabolism; Virus Diseases - virology; viperin; radical SAM protein; RSAD2; interferon; chain terminator; RNA-dependent RNA polymerase

Most cells respond to viral infections by activating innate immune pathways that lead to the induction of antiviral restriction factors. One such factor, viperin, was discovered almost two decades ago based on its induction during viral infection. Since then, viperin has been shown to possess activi...