The Three-Dimensional Organization of Mammalian Genomes

• Published in: Annual review of cell and developmental biology Vol. 33; p. 265
• Main Authors: Yu, Miao, Ren, Bing
• Format: Journal Article
• Language: English
• Published: United States 06.10.2017
• Subjects: chromosome conformation capture; 3D chromatin organization; gene regulation; topologically associating domain; TAD

Animal development depends on not only the linear genome sequence that embeds millions of cis-regulatory elements, but also the three-dimensional (3D) chromatin architecture that orchestrates the interplay between cis-regulatory elements and their target genes. Compared to our knowledge of the cis-r...