Microbial translocation across the GI tract
The lumen of the gastrointestinal (GI) tract is home to an enormous quantity of different bacterial species, our microbiota, that thrive in an often symbiotic relationship with the host. Given that the healthy host must regulate contact between the microbiota and its immune system to avoid overwhelm...
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| Published in | Annual review of immunology Vol. 30; p. 149 |
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| Main Authors | , |
| Format | Journal Article |
| Language | English |
| Published |
United States
01.01.2012
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| Subjects | |
| Online Access | Get more information |
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| Abstract | The lumen of the gastrointestinal (GI) tract is home to an enormous quantity of different bacterial species, our microbiota, that thrive in an often symbiotic relationship with the host. Given that the healthy host must regulate contact between the microbiota and its immune system to avoid overwhelming systemic immune activation, humans have evolved several mechanisms to attenuate systemic microbial translocation (MT) and its consequences. However, several diseases are associated with the failure of one or more of these mechanisms, with consequent immune activation and deleterious effects on health. Here, we discuss the mechanisms underlying MT, diseases associated with MT, and therapeutic interventions that aim to decrease it. |
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| AbstractList | The lumen of the gastrointestinal (GI) tract is home to an enormous quantity of different bacterial species, our microbiota, that thrive in an often symbiotic relationship with the host. Given that the healthy host must regulate contact between the microbiota and its immune system to avoid overwhelming systemic immune activation, humans have evolved several mechanisms to attenuate systemic microbial translocation (MT) and its consequences. However, several diseases are associated with the failure of one or more of these mechanisms, with consequent immune activation and deleterious effects on health. Here, we discuss the mechanisms underlying MT, diseases associated with MT, and therapeutic interventions that aim to decrease it. |
| Author | Douek, Daniel C Brenchley, Jason M |
| Author_xml | – sequence: 1 givenname: Jason M surname: Brenchley fullname: Brenchley, Jason M email: jbrenchl@mail.nih.gov organization: Program in Barrier Immunity and Repair and Immunopathogenesis Unit, Lab of Molecular Microbiology, NIAID, NIH, Bethesda, Maryland, USA. jbrenchl@mail.nih.gov – sequence: 2 givenname: Daniel C surname: Douek fullname: Douek, Daniel C |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/22224779$$D View this record in MEDLINE/PubMed |
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| SubjectTerms | Animals Anti-Infective Agents - pharmacology Anti-Infective Agents - therapeutic use Digestive System Diseases - immunology Digestive System Diseases - microbiology Digestive System Diseases - therapy Gastrointestinal Tract - drug effects Gastrointestinal Tract - immunology Gastrointestinal Tract - microbiology Host-Pathogen Interactions - immunology Humans Immunologic Factors - pharmacology Immunologic Factors - therapeutic use Metagenome - drug effects Metagenome - physiology Probiotics - therapeutic use |
| Title | Microbial translocation across the GI tract |
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