Gallium(III)–Salophen as a Dual Inhibitor of Pseudomonas aeruginosa Heme Sensing and Iron Acquisition

• Published in: ACS infectious diseases Vol. 6; no. 8; pp. 2073 - 2085
• Main Authors: Centola, Garrick, Deredge, Daniel J, Hom, Kellie, Ai, Yong, Dent, Alecia T, Xue, Fengtian, Wilks, Angela
• Format: Journal Article
• Language: English
• Published: American Chemical Society 14.08.2020
• Subjects: Pseudomonas aeruginosa; heme sensing; antimicrobials; heme uptake; metallotherapeutics

Pseudomonas aeruginosa is an opportunistic bacterium that causes life-threatening infections in immunocompromised patients. In infection, it uses heme as a primary iron source and senses the availability of exogenous heme through the heme assimilation system (Has), an extra cytoplasmic function σ-fa...