The Driving Force: Nuclear Mechanotransduction in Cellular Function, Fate, and Disease

• Published in: Annual review of biomedical engineering Vol. 21; p. 443
• Main Authors: Maurer, Melanie, Lammerding, Jan
• Format: Journal Article
• Language: English
• Published: United States 04.06.2019
• Subjects: Animals; Biomedical Engineering; Cell Nucleus - physiology; Cell Nucleus - ultrastructure; Chromatin - chemistry; Chromatin - physiology; Cytoskeleton - physiology; Humans; Lamins - genetics; Lamins - physiology; Mechanotransduction, Cellular - physiology; Models, Biological; Nuclear Proteins - chemistry; Nuclear Proteins - physiology; Phosphorylation; Protein Conformation; Stem Cell Niche - physiology; Stem Cells - physiology; Tissue Engineering; LINC complex; stem cells; lamin; nuclear mechanics; laminopathies; mechanotransduction

Cellular behavior is continuously affected by microenvironmental forces through the process of mechanotransduction, in which mechanical stimuli are rapidly converted to biochemical responses. Mounting evidence suggests that the nucleus itself is a mechanoresponsive element, reacting to cytoskeletal...