Peridinin Is an Exceptionally Potent and Membrane-Embedded Inhibitor of Bilayer Lipid Peroxidation

• Published in: Journal of the American Chemical Society Vol. 140; no. 45; pp. 15227 - 15240
• Main Authors: Haley, Hannah M. S, Hill, Adam G, Greenwood, Alexander I, Woerly, Eric M, Rienstra, Chad M, Burke, Martin D
• Format: Journal Article
• Language: English
• Published: WASHINGTON American Chemical Society 14.11.2018; Amer Chemical Soc
• Subjects: astaxanthin; atherogenesis; carbon; Carotenoids - chemistry; Carotenoids - pharmacology; cell adhesion; Chemistry; Chemistry, Multidisciplinary; clinical trials; endothelial cells; human diseases; Human Umbilical Vein Endothelial Cells - drug effects; Human Umbilical Vein Endothelial Cells - metabolism; Humans; hydrophobicity; isotope labeling; Lipid Bilayers - antagonists & inhibitors; Lipid Bilayers - metabolism; lipid peroxidation; Lipid Peroxidation - drug effects; microorganisms; Molecular Structure; nuclear magnetic resonance spectroscopy; oxidative stress; pathogenesis; Physical Sciences; Science & Technology; stable isotopes; therapeutics; BETA-CAROTENE; OXIDATIVE STRESS; ROTATING SOLIDS; LIQUID-CHROMATOGRAPHY; BUILDING-BLOCKS; NUCLEAR-MAGNETIC-RESONANCE; PHOSPHOLIPID-BILAYER; MONOCYTE ADHESION; ALGA CHLAMYDOMONAS-NIVALIS; IMMERSION DEPTH

Antilipoperoxidant protein dysfunction is associated with many human diseases, suggesting that bilayer lipid peroxidation may contribute broadly to pathogenesis. Small molecule inhibitors of this membrane-localized chemistry could in theory enable better understanding and/or treatment of such diseas...