Selective Loss of Smaller Spines in Schizophrenia

• Published in: American Journal of Psychiatry Vol. 174; no. 6; pp. 586 - 594
• Main Authors: MacDonald, Matthew L, Alhassan, Jamil, Newman, Jason T, Richard, Michelle, Gu, Hong, Kelly, Ryan M, Sampson, Alan R, Fish, Kenneth N, Penzes, Peter, Wills, Zachary P, Lewis, David A, Sweet, Robert A
• Format: Journal Article
• Language: English
• Published: United States American Psychiatric Association 01.06.2017
• Subjects: Adult; Auditory Cortex - physiopathology; Calcium; Calcium Channels - genetics; Case-Control Studies; Cohort Studies; Correlation analysis; Dendritic cells; Dendritic Spines - genetics; Dendritic Spines - pathology; Dendritic Spines - physiology; Genetic Predisposition to Disease - genetics; Humans; Immunohistochemistry; Infant; Male; Mass Spectrometry; Middle Aged; Neuronal Plasticity - physiology; Protein expression; Risk assessment; Schizophrenia; Schizophrenia - diagnosis; Schizophrenia - genetics; Schizophrenia - pathology; Schizophrenia - physiopathology; Schizophrenic Psychology; Statistics as Topic; Synapses - physiology; Schizophrenia; Calcium Channel; Neuropathology; Dendritic Spines; Proteomics

Objective:Decreased density of dendritic spines in adult schizophrenia subjects has been hypothesized to result from increased pruning of excess synapses in adolescence. In vivo imaging studies have confirmed that synaptic pruning is largely driven by the loss of large or mature synapses. Thus, incr...