Anti-Human Immunodeficiency Virus Type 1 Activity of the Nonnucleoside Reverse Transcriptase Inhibitor GW678248 in Combination with Other Antiretrovirals against Clinical Isolate Viruses and In Vitro Selection for Resistance

• Published in: Antimicrobial Agents and Chemotherapy Vol. 49; no. 11; pp. 4465 - 4473
• Main Authors: HAZEN, Richard J, HARVEY, Robert J, CHAN, Joseph H, BOONE, Lawrence R, CLAIR, Marty H. St, FERRIS, Robert G, FREEMAN, George A, TIDWELL, Jeffrey H, SCHALLER, Lee T, COWAN, Jill R, SHORT, Steven A, ROMINES, Karen R
• Format: Journal Article
• Language: English
• Published: Washington, DC American Society for Microbiology 01.11.2005
• Subjects: Acquired Immunodeficiency Syndrome - drug therapy; Anti-HIV Agents; Anti-HIV Agents - pharmacology; Antibiotics. Antiinfectious agents. Antiparasitic agents; Antiretroviral Therapy, Highly Active; Antiviral Agents; Biological and medical sciences; Cell Line; Dose-Response Relationship, Drug; Drug Resistance, Viral; Drug Therapy, Combination; HIV Reverse Transcriptase; HIV Reverse Transcriptase - antagonists & inhibitors; HIV Reverse Transcriptase - genetics; HIV-1; HIV-1 - drug effects; HIV-1 - genetics; Human viral diseases; Humans; Immunodeficiencies; Immunodeficiencies. Immunoglobulinopathies; Immunopathology; Infectious diseases; Medical sciences; Nitriles; Nitriles - pharmacology; Pharmacology. Drug treatments; Phenotype; Reverse Transcriptase Inhibitors; Reverse Transcriptase Inhibitors - pharmacology; Sulfonamides; Sulfonamides - pharmacology; Viral diseases; Viral diseases of the lymphoid tissue and the blood. Aids; Human; Immunopathology; Antiretroviral agent; Drug combination; HIV-1 virus; Selection; Retroviridae; AIDS; Immune deficiency; Lentivirus; In vitro; Biological activity; Infection; Virus; Resistance; Viral disease; Reverse transcriptase inhibitor; Antiviral; Human immunodeficiency virus; Clinical isolate
• ISSN: 0066-4804; 1098-6596
• DOI: 10.1128/AAC.49.11.4465-4473.2005

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