Investigating the Contribution of Common Genetic Variants to the Risk and Pathogenesis of ADHD

• Published in: The American journal of psychiatry Vol. 169; no. 2; pp. 186 - 194
• Main Authors: Stergiakouli, Evangelia, Hamshere, Marian, Holmans, Peter, Langley, Kate, Zaharieva, Irina, Hawi, Ziarah, Kent, Lindsey, Gill, Michael, Williams, Nigel, Owen, Michael J., O'Donovan, Michael, Thapar, Anita
• Format: Journal Article
• Language: English
• Published: United States American Psychiatric Publishing 01.02.2012; American Psychiatric Association
• Subjects: Adolescent; alpha7 Nicotinic Acetylcholine Receptor; Attention Deficit Disorder with Hyperactivity - genetics; Attention deficit hyperactivity disorder; Child; Female; Gene Dosage; Genetic Predisposition to Disease; Genetics; Genome-Wide Association Study; Humans; Inheritance Patterns - genetics; Linkage Disequilibrium; Male; New Research; Polymorphism, Single Nucleotide; Psychiatry; Psychopathology; Receptors, Nicotinic - genetics; Risk Assessment

Objective:A major motivation for seeking disease-associated genetic variation is to identify novel risk processes. Although rare copy number variants (CNVs) appear to contribute to attention deficit hyperactivity disorder (ADHD), common risk variants (single-nucleotide polymorphisms [SNPs]) have not...