Molecular Analysis of Isoniazid-Resistant Mycobacterium tuberculosis Isolates from England and Wales Reveals the Phylogenetic Significance of the ahpC −46A Polymorphism
Classifications Services AAC Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit StumbleUpon Twitter current issue AAC About AAC Subscribers Authors Reviewers Advertisers Inquiries from the Press Permissions & Commerc...
Saved in:
| Published in | Antimicrobial Agents and Chemotherapy Vol. 49; no. 4; pp. 1455 - 1464 |
|---|---|
| Main Authors | , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
Washington, DC
American Society for Microbiology
01.04.2005
|
| Subjects | |
| Online Access | Get full text |
| ISSN | 0066-4804 1098-6596 |
| DOI | 10.1128/AAC.49.4.1455-1464.2005 |
Cover
Loading…
| Abstract | Classifications
Services
AAC
Citing Articles
Google Scholar
PubMed
Related Content
Social Bookmarking
CiteULike
Delicious
Digg
Facebook
Google+
Mendeley
Reddit
StumbleUpon
Twitter
current issue
AAC
About
AAC
Subscribers
Authors
Reviewers
Advertisers
Inquiries from the Press
Permissions & Commercial Reprints
ASM Journals Public Access Policy
AAC
RSS Feeds
1752 N Street N.W. • Washington DC 20036
202.737.3600 • 202.942.9355 fax • journals@asmusa.org
Print ISSN:
0066-4804
Online ISSN:
1098-6596
Copyright © 2014
by the
American Society for Microbiology.
For an alternate route to
AAC
.asm.org, visit:
AAC
|
|---|---|
| AbstractList | The present study investigated the prevalence and diagnostic potential of the most commonly reported mutations associated with isoniazid resistance,
katG
315Thr,
katG
315Asn,
inhA
−15T,
inhA
−8A, and the
oxyR
-
ahpC
intergenic region, in a population sample of 202 isoniazid-resistant
Mycobacterium tuberculosis
isolates and 176 randomly selected fully sensitive isolates from England and Wales identified by using a directed oligonucleotide array and limited DNA sequencing. The strains were recovered from patients originating from 29 countries; 41 isolates were multidrug resistant. Mutations affecting
katG
315, the
inhA
promoter, and the
oxyR
-
ahpC
intergenic region were found in 62.7, 21.9, and 30% of 169 genotypically distinct isoniazid-resistant isolates, respectively, whereas they were found in 0, 0, and 8% of susceptible strains, respectively. The frequency of mutation at each locus was unrelated to the resistance profile or previous antituberculous drug therapy. The commonest mutation in the
oxyR
-
ahpC
intergenic region,
ahpC
−46A, was present in 23.7% of isoniazid-resistant isolates and 7.5% of susceptible isolates. This proved to be a phylogenetic marker for a subgroup of
M. tuberculosis
strains originating on the Indian subcontinent, which shared IS
6110
-based restriction fragment length polymorphism and spoligotype features with the Delhi strain and Central Asian strain CAS1; and this marker is strongly associated with isoniazid resistance and the
katG
315Thr mutation. In total, 82.8% of unrelated isoniazid-resistant isolates could be identified by analysis of just two loci:
katG
315 and the
inhA
promoter. Analysis of the
oxyR
-
ahpC
intergenic region, although phylogenetically interesting, does not contribute significantly to further identification of isoniazid-resistant isolates. Classifications Services AAC Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit StumbleUpon Twitter current issue AAC About AAC Subscribers Authors Reviewers Advertisers Inquiries from the Press Permissions & Commercial Reprints ASM Journals Public Access Policy AAC RSS Feeds 1752 N Street N.W. • Washington DC 20036 202.737.3600 • 202.942.9355 fax • journals@asmusa.org Print ISSN: 0066-4804 Online ISSN: 1098-6596 Copyright © 2014 by the American Society for Microbiology. For an alternate route to AAC .asm.org, visit: AAC The present study investigated the prevalence and diagnostic potential of the most commonly reported mutations associated with isoniazid resistance, katG 315Thr, katG 315Asn, inhA -15T, inhA -8A, and the oxyR-ahpC intergenic region, in a population sample of 202 isoniazid-resistant Mycobacterium tuberculosis isolates and 176 randomly selected fully sensitive isolates from England and Wales identified by using a directed oligonucleotide array and limited DNA sequencing. The strains were recovered from patients originating from 29 countries; 41 isolates were multidrug resistant. Mutations affecting katG 315, the inhA promoter, and the oxyR-ahpC intergenic region were found in 62.7, 21.9, and 30% of 169 genotypically distinct isoniazid-resistant isolates, respectively, whereas they were found in 0, 0, and 8% of susceptible strains, respectively. The frequency of mutation at each locus was unrelated to the resistance profile or previous antituberculous drug therapy. The commonest mutation in the oxyR-ahpC intergenic region, ahpC -46A, was present in 23.7% of isoniazid-resistant isolates and 7.5% of susceptible isolates. This proved to be a phylogenetic marker for a subgroup of M. tuberculosis strains originating on the Indian subcontinent, which shared IS6110-based restriction fragment length polymorphism and spoligotype features with the Delhi strain and Central Asian strain CAS1; and this marker is strongly associated with isoniazid resistance and the katG 315Thr mutation. In total, 82.8% of unrelated isoniazid-resistant isolates could be identified by analysis of just two loci: katG 315 and the inhA promoter. Analysis of the oxyR-ahpC intergenic region, although phylogenetically interesting, does not contribute significantly to further identification of isoniazid-resistant isolates. The present study investigated the prevalence and diagnostic potential of the most commonly reported mutations associated with isoniazid resistance, katG 315Thr, katG 315Asn, inhA −15T, inhA −8A, and the oxyR-ahpC intergenic region, in a population sample of 202 isoniazid-resistant Mycobacterium tuberculosis isolates and 176 randomly selected fully sensitive isolates from England and Wales identified by using a directed oligonucleotide array and limited DNA sequencing. The strains were recovered from patients originating from 29 countries; 41 isolates were multidrug resistant. Mutations affecting katG 315, the inhA promoter, and the oxyR-ahpC intergenic region were found in 62.7, 21.9, and 30% of 169 genotypically distinct isoniazid-resistant isolates, respectively, whereas they were found in 0, 0, and 8% of susceptible strains, respectively. The frequency of mutation at each locus was unrelated to the resistance profile or previous antituberculous drug therapy. The commonest mutation in the oxyR-ahpC intergenic region, ahpC −46A, was present in 23.7% of isoniazid-resistant isolates and 7.5% of susceptible isolates. This proved to be a phylogenetic marker for a subgroup of M. tuberculosis strains originating on the Indian subcontinent, which shared IS6110-based restriction fragment length polymorphism and spoligotype features with the Delhi strain and Central Asian strain CAS1; and this marker is strongly associated with isoniazid resistance and the katG 315Thr mutation. In total, 82.8% of unrelated isoniazid-resistant isolates could be identified by analysis of just two loci: katG 315 and the inhA promoter. Analysis of the oxyR-ahpC intergenic region, although phylogenetically interesting, does not contribute significantly to further identification of isoniazid-resistant isolates. The present study investigated the prevalence and diagnostic potential of the most commonly reported mutations associated with isoniazid resistance, katG 315Thr, katG 315Asn, inhA -15T, inhA -8A, and the oxyR-ahpC intergenic region, in a population sample of 202 isoniazid-resistant Mycobacterium tuberculosis isolates and 176 randomly selected fully sensitive isolates from England and Wales identified by using a directed oligonucleotide array and limited DNA sequencing. The strains were recovered from patients originating from 29 countries; 41 isolates were multidrug resistant. Mutations affecting katG 315, the inhA promoter, and the oxyR-ahpC intergenic region were found in 62.7, 21.9, and 30% of 169 genotypically distinct isoniazid-resistant isolates, respectively, whereas they were found in 0, 0, and 8% of susceptible strains, respectively. The frequency of mutation at each locus was unrelated to the resistance profile or previous antituberculous drug therapy. The commonest mutation in the oxyR-ahpC intergenic region, ahpC -46A, was present in 23.7% of isoniazid-resistant isolates and 7.5% of susceptible isolates. This proved to be a phylogenetic marker for a subgroup of M. tuberculosis strains originating on the Indian subcontinent, which shared IS6110-based restriction fragment length polymorphism and spoligotype features with the Delhi strain and Central Asian strain CAS1; and this marker is strongly associated with isoniazid resistance and the katG 315Thr mutation. In total, 82.8% of unrelated isoniazid-resistant isolates could be identified by analysis of just two loci: katG 315 and the inhA promoter. Analysis of the oxyR-ahpC intergenic region, although phylogenetically interesting, does not contribute significantly to further identification of isoniazid-resistant isolates.The present study investigated the prevalence and diagnostic potential of the most commonly reported mutations associated with isoniazid resistance, katG 315Thr, katG 315Asn, inhA -15T, inhA -8A, and the oxyR-ahpC intergenic region, in a population sample of 202 isoniazid-resistant Mycobacterium tuberculosis isolates and 176 randomly selected fully sensitive isolates from England and Wales identified by using a directed oligonucleotide array and limited DNA sequencing. The strains were recovered from patients originating from 29 countries; 41 isolates were multidrug resistant. Mutations affecting katG 315, the inhA promoter, and the oxyR-ahpC intergenic region were found in 62.7, 21.9, and 30% of 169 genotypically distinct isoniazid-resistant isolates, respectively, whereas they were found in 0, 0, and 8% of susceptible strains, respectively. The frequency of mutation at each locus was unrelated to the resistance profile or previous antituberculous drug therapy. The commonest mutation in the oxyR-ahpC intergenic region, ahpC -46A, was present in 23.7% of isoniazid-resistant isolates and 7.5% of susceptible isolates. This proved to be a phylogenetic marker for a subgroup of M. tuberculosis strains originating on the Indian subcontinent, which shared IS6110-based restriction fragment length polymorphism and spoligotype features with the Delhi strain and Central Asian strain CAS1; and this marker is strongly associated with isoniazid resistance and the katG 315Thr mutation. In total, 82.8% of unrelated isoniazid-resistant isolates could be identified by analysis of just two loci: katG 315 and the inhA promoter. Analysis of the oxyR-ahpC intergenic region, although phylogenetically interesting, does not contribute significantly to further identification of isoniazid-resistant isolates. |
| Author | A. L. Gibson F. A. Drobniewski Z. Fang T. J. Brown M. D. Yates O. Maxwell L. V. Baker |
| AuthorAffiliation | HPA Mycobacterium Reference Unit, Department of Microbiology, Guy's, King's and St Thomas' School of Medicine, King's College Hospital, London, United Kingdom |
| AuthorAffiliation_xml | – name: HPA Mycobacterium Reference Unit, Department of Microbiology, Guy's, King's and St Thomas' School of Medicine, King's College Hospital, London, United Kingdom |
| Author_xml | – sequence: 1 givenname: L. V. surname: Baker fullname: Baker, L. V. organization: HPA Mycobacterium Reference Unit, Department of Microbiology, Guy's, King's and St Thomas' School of Medicine, King's College Hospital, London, United Kingdom – sequence: 2 givenname: T. J. surname: Brown fullname: Brown, T. J. organization: HPA Mycobacterium Reference Unit, Department of Microbiology, Guy's, King's and St Thomas' School of Medicine, King's College Hospital, London, United Kingdom – sequence: 3 givenname: O. surname: Maxwell fullname: Maxwell, O. organization: HPA Mycobacterium Reference Unit, Department of Microbiology, Guy's, King's and St Thomas' School of Medicine, King's College Hospital, London, United Kingdom – sequence: 4 givenname: A. L. surname: Gibson fullname: Gibson, A. L. organization: HPA Mycobacterium Reference Unit, Department of Microbiology, Guy's, King's and St Thomas' School of Medicine, King's College Hospital, London, United Kingdom – sequence: 5 givenname: Z. surname: Fang fullname: Fang, Z. organization: HPA Mycobacterium Reference Unit, Department of Microbiology, Guy's, King's and St Thomas' School of Medicine, King's College Hospital, London, United Kingdom – sequence: 6 givenname: M. D. surname: Yates fullname: Yates, M. D. organization: HPA Mycobacterium Reference Unit, Department of Microbiology, Guy's, King's and St Thomas' School of Medicine, King's College Hospital, London, United Kingdom – sequence: 7 givenname: F. A. surname: Drobniewski fullname: Drobniewski, F. A. organization: HPA Mycobacterium Reference Unit, Department of Microbiology, Guy's, King's and St Thomas' School of Medicine, King's College Hospital, London, United Kingdom |
| BackLink | http://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=16686907$$DView record in Pascal Francis https://www.ncbi.nlm.nih.gov/pubmed/15793126$$D View this record in MEDLINE/PubMed |
| BookMark | eNqNks9u1DAQxiNURP_AK4A5wC2LnThOfABptSpQqRVVAXG0Jo6zceXYi-0ULU_AmcfgsXgSHG1pgUs5WJbt3zfjmfkOsz3rrMqyJwQvCCmaF8vlakH5gi4IraqcUEYXBcbVveyAYN7krOJsLzvAmLGcNpjuZ4chXOJ0rjh-kO2TquYlKdhB9uPMGSUnAx4tLZht0AG5Hp0EZzV81V1-odJVBBvR2Va6FmRUXk8jilOrfBK6WZFwA1EF1Hs3omO7NmA7NK9PYNL1hbpSYAKKg0Lnw9a4tbIqaone67XVvZZgpZrzzgAMmxX6-e07ZUt07sx2dH4z6DA-zO73KYh6dL0fZR9fH39Yvc1P3705WS1Pc6hoHfNUYdcAZrKGgkkJXckL3lHcsx5aXlaKUFWVvEk0tIy0EpddXyvG25YVCpryKHu1i7uZ2lF1UtnowYiN1yP4rXCgxd8vVg9i7a4EwaxhmKUAz68DePd5UiGKUQepTGqKclMQrK6qmnB-J0jqhjLc4ATSHQhhLMSlm3yaVXrHYnaDSG4QlAsqZjeI2Q1idkOSPf6zkpsSfo8_Ac-uAQgSTO_THHS45VgqiOM6cS93nPQuBK96IXWEqN3cAG3-4yP1P_qbFHcqn-6Ug14PX7RXIrVAAMhbuvwFegj0Jg |
| CODEN | AACHAX |
| CitedBy_id | crossref_primary_10_1016_j_mimet_2007_05_015 crossref_primary_10_1093_jac_dkv253 crossref_primary_10_1016_j_jctube_2017_06_001 crossref_primary_10_1128_JCM_01960_06 crossref_primary_10_1016_j_meegid_2016_09_004 crossref_primary_10_1016_j_tube_2018_08_001 crossref_primary_10_1128_AAC_50_3_1075_1078_2006 crossref_primary_10_1128_JCM_01249_17 crossref_primary_10_1128_JCM_02499_08 crossref_primary_10_1128_JCM_44_5_1619_1624_2006 crossref_primary_10_1016_S1413_8670_12_70275_1 crossref_primary_10_1128_AAC_00974_18 crossref_primary_10_1371_journal_pone_0099810 crossref_primary_10_1016_j_mimet_2008_05_023 crossref_primary_10_1093_jac_dkp183 crossref_primary_10_1164_rccm_200709_1436OC crossref_primary_10_1016_j_tube_2013_10_001 crossref_primary_10_1186_1741_7015_11_190 crossref_primary_10_1007_s10096_008_0548_9 crossref_primary_10_1016_j_tube_2009_03_001 crossref_primary_10_1093_jac_dkq514 crossref_primary_10_1016_j_tube_2011_07_005 crossref_primary_10_1007_s00894_011_1200_7 crossref_primary_10_1128_AAC_00309_08 crossref_primary_10_1099_jmm_0_46718_0 crossref_primary_10_4103_0255_0857_167336 crossref_primary_10_1016_j_jmoldx_2014_06_008 crossref_primary_10_1016_j_ijantimicag_2008_01_008 crossref_primary_10_1128_JCM_00330_06 crossref_primary_10_1128_JCM_01054_06 crossref_primary_10_1080_00365540802570519 crossref_primary_10_1007_s40265_014_0248_y crossref_primary_10_1016_j_meegid_2009_09_008 crossref_primary_10_1186_1471_2334_10_41 crossref_primary_10_1089_mdr_2008_0842 crossref_primary_10_1016_j_ijid_2015_01_014 crossref_primary_10_1128_JCM_00982_12 crossref_primary_10_1371_journal_pone_0119628 crossref_primary_10_1016_j_diagmicrobio_2017_07_010 crossref_primary_10_1093_jac_dkq492 crossref_primary_10_1128_AAC_00112_06 crossref_primary_10_1128_AAC_49_10_4068_4074_2005 crossref_primary_10_1128_microbiolspec_MGM2_0014_2013 crossref_primary_10_1186_1476_0711_8_4 crossref_primary_10_1128_microbiolspec_MGM2_0036_2013 crossref_primary_10_1016_j_ijantimicag_2020_106068 crossref_primary_10_1016_j_meegid_2008_06_006 crossref_primary_10_1021_acs_analchem_4c04166 crossref_primary_10_1111_j_1469_0691_2007_01813_x crossref_primary_10_1016_j_cegh_2019_12_002 crossref_primary_10_3343_alm_2015_35_5_494 crossref_primary_10_1016_j_jgar_2020_02_026 |
| Cites_doi | 10.1128/AAC.47.4.1241-1250.2003 10.1128/JCM.39.2.636-641.2001 10.3201/eid0811.020125 10.1016/0140-6736(93)90417-F 10.1046/j.1365-2958.2002.03162.x 10.1128/AAC.40.9.2187 10.1128/JCM.36.7.1969-1973.1998 10.1126/science.118.3063.297 10.1128/JCM.38.2.781-788.2000 10.1128/JCM.40.10.3789-3792.2002 10.1093/infdis/173.1.196 10.1128/AAC.41.3.600 10.1128/JCM.40.6.1930-1937.2002 10.1016/j.mimet.2004.02.006 10.1128/AAC.41.9.2057 10.1001/jama.1996.03530300036037 10.1086/514096 10.1046/j.1365-2958.1996.00133.x 10.1128/jcm.35.3.719-723.1997 10.1016/0962-8479(95)90009-8 10.3201/eid0811.020507 10.1016/S0167-7012(00)00175-5 10.1128/AAC.42.9.2443 10.1016/S0966-842X(01)02277-6 10.1038/358591a0 10.1086/317598 10.1128/jcm.31.2.406-409.1993 10.1128/jcm.35.4.907-914.1997 10.1054/tube.2002.0332 10.1086/314930 10.1093/infdis/171.4.954 10.1046/j.1365-2958.1996.449980.x 10.1128/AAC.39.11.2472 10.1093/clinids/24.5.894 10.1126/science.272.5268.1641 10.1054/tuld.1999.0231 10.1128/JCM.39.9.3339-3345.2001 10.1128/AAC.47.6.2009-2011.2003 10.1136/thorax.56.3.173 10.1128/iai.65.4.1395-1401.1997 10.1128/AAC.46.5.1417-1424.2002 10.1073/pnas.94.18.9869 10.1054/tuld.1998.0002 10.3201/eid0808.020002 10.1128/AAC.44.1.103-110.2000 10.1128/jcm.33.12.3234-3238.1995 10.1126/science.8284673 10.1056/NEJM200104263441706 10.1136/thorax.57.6.562 |
| ContentType | Journal Article |
| Copyright | 2005 INIST-CNRS Copyright © 2005 American Society for Microbiology Copyright © 2005, American Society for Microbiology 2005 |
| Copyright_xml | – notice: 2005 INIST-CNRS – notice: Copyright © 2005 American Society for Microbiology – notice: Copyright © 2005, American Society for Microbiology 2005 |
| DBID | AAYXX CITATION IQODW CGR CUY CVF ECM EIF NPM 7QL C1K 7X8 5PM |
| DOI | 10.1128/AAC.49.4.1455-1464.2005 |
| DatabaseName | CrossRef Pascal-Francis Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed Bacteriology Abstracts (Microbiology B) Environmental Sciences and Pollution Management MEDLINE - Academic PubMed Central (Full Participant titles) |
| DatabaseTitle | CrossRef MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) Bacteriology Abstracts (Microbiology B) Environmental Sciences and Pollution Management MEDLINE - Academic |
| DatabaseTitleList | Bacteriology Abstracts (Microbiology B) CrossRef MEDLINE - Academic MEDLINE |
| Database_xml | – sequence: 1 dbid: NPM name: PubMed url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 2 dbid: EIF name: MEDLINE url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search sourceTypes: Index Database |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Medicine Pharmacy, Therapeutics, & Pharmacology Biology |
| EISSN | 1098-6596 |
| EndPage | 1464 |
| ExternalDocumentID | PMC1068606 0862-04 15793126 16686907 10_1128_AAC_49_4_1455_1464_2005 aac_49_4_1455 |
| Genre | Research Support, Non-U.S. Gov't Journal Article |
| GeographicLocations | England United Kingdom Great Britain Europe Wales |
| GeographicLocations_xml | – name: Wales – name: England |
| GroupedDBID | --- .55 .GJ 0R~ 23M 2WC 39C 3O- 4.4 53G 5GY 5RE 5VS 6J9 AAGFI AAYXX ACGFO ADBBV AENEX AGNAY AGVNZ AI. ALMA_UNASSIGNED_HOLDINGS AOIJS BAWUL BTFSW C1A CITATION CS3 DIK E3Z EBS EJD F5P FRP GX1 H13 HH5 HYE HZ~ H~9 J5H K-O KQ8 L7B LSO MVM NEJ O9- OK1 P2P RHI RNS RPM RSF TR2 UHB VH1 W2D W8F WH7 WHG WOQ X7M X7N XOL Y6R ZGI ZXP ~A~ IQODW CGR CUY CVF ECM EIF NPM RHF - 08R 0R 55 A AAPBV ABFLS ADACO ADBIT AFMIJ BXI GJ HZ ZA5 7QL C1K 7X8 5PM |
| ID | FETCH-LOGICAL-a547t-590d8a06c7a26ccad3929d40f6fab935e14e5398a54ab61bc03df7e69bb62ea83 |
| ISSN | 0066-4804 |
| IngestDate | Thu Aug 21 17:30:08 EDT 2025 Thu Jul 10 20:53:43 EDT 2025 Sun Aug 24 03:42:59 EDT 2025 Tue Dec 28 13:59:06 EST 2021 Sat Sep 28 07:45:08 EDT 2024 Mon Jul 21 09:15:04 EDT 2025 Tue Jul 01 02:00:09 EDT 2025 Thu Apr 24 23:10:41 EDT 2025 Wed May 18 15:34:11 EDT 2016 |
| IsDoiOpenAccess | false |
| IsOpenAccess | true |
| IsPeerReviewed | true |
| IsScholarly | true |
| Issue | 4 |
| Keywords | Resistance Mycobacterium tuberculosis Mycobacteriales Mycobacteriaceae Bacteria Isolate Actinomycetes Antituberculous agent Phylogeny Antibacterial agent Isoniazid Polymorphism |
| Language | English |
| License | CC BY 4.0 |
| LinkModel | OpenURL |
| MergedId | FETCHMERGED-LOGICAL-a547t-590d8a06c7a26ccad3929d40f6fab935e14e5398a54ab61bc03df7e69bb62ea83 |
| Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 Corresponding author. Mailing address: HPA Mycobacterium Reference Unit, Department of Microbiology, Guy's, King's and St Thomas' School of Medicine, King's College Hospital, East Dulwich Grove, London SE22 8QF, United Kingdom. Phone: 44 20 8333 3000. Fax: 44 20 8333 3092. E-mail: francis.drobniewski@kcl.ac.uk. |
| OpenAccessLink | http://doi.org/10.1128/AAC.49.4.1455-1464.2005 |
| PMID | 15793126 |
| PQID | 17846080 |
| PQPubID | 23462 |
| PageCount | 10 |
| ParticipantIDs | asm2_journals_10_1128_AAC_49_4_1455_1464_2005 pascalfrancis_primary_16686907 crossref_citationtrail_10_1128_AAC_49_4_1455_1464_2005 crossref_primary_10_1128_AAC_49_4_1455_1464_2005 proquest_miscellaneous_17846080 proquest_miscellaneous_67557199 pubmedcentral_primary_oai_pubmedcentral_nih_gov_1068606 pubmed_primary_15793126 highwire_asm_aac_49_4_1455 |
| ProviderPackageCode | CITATION AAYXX |
| PublicationCentury | 2000 |
| PublicationDate | 2005-04-01 |
| PublicationDateYYYYMMDD | 2005-04-01 |
| PublicationDate_xml | – month: 04 year: 2005 text: 2005-04-01 day: 01 |
| PublicationDecade | 2000 |
| PublicationPlace | Washington, DC |
| PublicationPlace_xml | – name: Washington, DC – name: United States |
| PublicationTitle | Antimicrobial Agents and Chemotherapy |
| PublicationTitleAbbrev | AAC |
| PublicationTitleAlternate | Antimicrob Agents Chemother |
| PublicationYear | 2005 |
| Publisher | American Society for Microbiology |
| Publisher_xml | – name: American Society for Microbiology |
| References | e_1_3_2_49_2 e_1_3_2_28_2 (e_1_3_2_45_2) 2002; 6 e_1_3_2_41_2 e_1_3_2_20_2 e_1_3_2_43_2 (e_1_3_2_37_2) 2001; 56 e_1_3_2_22_2 e_1_3_2_24_2 e_1_3_2_47_2 e_1_3_2_9_2 e_1_3_2_16_2 (e_1_3_2_36_2) 1998; 17 e_1_3_2_7_2 e_1_3_2_18_2 e_1_3_2_39_2 e_1_3_2_54_2 e_1_3_2_10_2 e_1_3_2_31_2 e_1_3_2_52_2 e_1_3_2_5_2 e_1_3_2_33_2 e_1_3_2_3_2 e_1_3_2_14_2 e_1_3_2_35_2 e_1_3_2_56_2 (e_1_3_2_11_2) 1998; 2 e_1_3_2_50_2 (e_1_3_2_26_2) 2002; 57 (e_1_3_2_19_2) 1995; 119 e_1_3_2_27_2 e_1_3_2_48_2 e_1_3_2_29_2 e_1_3_2_40_2 (e_1_3_2_12_2) 1997; 1 e_1_3_2_21_2 e_1_3_2_42_2 e_1_3_2_23_2 e_1_3_2_44_2 e_1_3_2_25_2 e_1_3_2_46_2 e_1_3_2_15_2 e_1_3_2_38_2 e_1_3_2_8_2 e_1_3_2_17_2 e_1_3_2_6_2 e_1_3_2_30_2 e_1_3_2_53_2 e_1_3_2_32_2 e_1_3_2_51_2 e_1_3_2_34_2 e_1_3_2_4_2 e_1_3_2_13_2 e_1_3_2_55_2 e_1_3_2_2_2 10897383 - Tuber Lung Dis. 2000;80(1):47-56 11182007 - Thorax. 2001 Mar;56(3):173-9 8095569 - Lancet. 1993 Mar 13;341(8846):647-50 9142789 - Clin Infect Dis. 1997 May;24(5):894-900 8537659 - J Infect Dis. 1996 Jan;173(1):196-202 10602730 - Antimicrob Agents Chemother. 2000 Jan;44(1):103-10 9041419 - J Clin Microbiol. 1997 Mar;35(3):719-23 9056000 - Antimicrob Agents Chemother. 1997 Mar;41(3):600-6 7496004 - Tuber Lung Dis. 1995 Oct;76(5):425-30 15134881 - J Microbiol Methods. 2004 Jun;57(3):323-35 8939440 - Mol Microbiol. 1996 Nov;22(3):583-92 11959577 - Antimicrob Agents Chemother. 2002 May;46(5):1417-24 7848059 - Arch Pathol Lab Med. 1995 Feb;119(2):131-8 8830260 - Mol Microbiol. 1996 Mar;19(5):1025-34 12354882 - J Clin Microbiol. 2002 Oct;40(10):3789-92 12141971 - Emerg Infect Dis. 2002 Aug;8(8):843-9 11158121 - J Clin Microbiol. 2001 Feb;39(2):636-41 11069256 - J Infect Dis. 2000 Dec;182(6):1788-90 1501713 - Nature. 1992 Aug 13;358(6387):591-3 9291321 - J Infect Dis. 1997 Sep;176(3):722-7 7706824 - J Infect Dis. 1995 Apr;171(4):954-60 9736581 - Antimicrob Agents Chemother. 1998 Sep;42(9):2443-5 12406221 - Mol Microbiol. 2002 Oct;46(2):453-66 9764555 - Eur J Clin Microbiol Infect Dis. 1998 Jul;17(7):508-11 8586708 - J Clin Microbiol. 1995 Dec;33(12):3234-8 12760887 - Antimicrob Agents Chemother. 2003 Jun;47(6):2009-11 8878604 - Antimicrob Agents Chemother. 1996 Sep;40(9):2187-9 8627966 - JAMA. 1996 Feb 14;275(6):452-7 12654653 - Antimicrob Agents Chemother. 2003 Apr;47(4):1241-50 11931416 - Int J Tuberc Lung Dis. 2002 Feb;6(2):160-3 8585728 - Antimicrob Agents Chemother. 1995 Nov;39(11):2472-7 12356462 - Tuberculosis (Edinb). 2002;82(2-3):105-12 10655385 - J Clin Microbiol. 2000 Feb;38(2):781-8 10438361 - J Infect Dis. 1999 Sep;180(3):726-36 9755929 - Int J Tuberc Lung Dis. 1998 Sep;2(9):743-50 13089681 - Science. 1953 Sep 11;118(3063):297-9 11320389 - N Engl J Med. 2001 Apr 26;344(17):1294-303 9119479 - Infect Immun. 1997 Apr;65(4):1395-401 12453368 - Emerg Infect Dis. 2002 Nov;8(11):1347-9 8381814 - J Clin Microbiol. 1993 Feb;31(2):406-9 11018277 - J Microbiol Methods. 2000 Oct;42(2):203-7 12453364 - Emerg Infect Dis. 2002 Nov;8(11):1320-6 8658136 - Science. 1996 Jun 14;272(5268):1641-3 9650946 - J Clin Microbiol. 1998 Jul;36(7):1969-73 9432394 - Int J Tuberc Lung Dis. 1997 Aug;1(4):365-9 12037045 - J Clin Microbiol. 2002 Jun;40(6):1930-7 9157152 - J Clin Microbiol. 1997 Apr;35(4):907-14 9275218 - Proc Natl Acad Sci U S A. 1997 Sep 2;94(18):9869-74 11755085 - Trends Microbiol. 2002 Jan;10(1):45-52 12037237 - Thorax. 2002 Jun;57(6):562-3 10645439 - Tuber Lung Dis. 1998;79(1):3-29 9303417 - Antimicrob Agents Chemother. 1997 Sep;41(9):2057-8 11526173 - J Clin Microbiol. 2001 Sep;39(9):3339-45 8284673 - Science. 1994 Jan 14;263(5144):227-30 |
| References_xml | – volume: 1 start-page: 365 year: 1997 ident: e_1_3_2_12_2 publication-title: Int. J. Tuberc. Lung Dis. – ident: e_1_3_2_35_2 doi: 10.1128/AAC.47.4.1241-1250.2003 – ident: e_1_3_2_49_2 doi: 10.1128/JCM.39.2.636-641.2001 – ident: e_1_3_2_15_2 doi: 10.3201/eid0811.020125 – ident: e_1_3_2_44_2 doi: 10.1016/0140-6736(93)90417-F – ident: e_1_3_2_23_2 doi: 10.1046/j.1365-2958.2002.03162.x – ident: e_1_3_2_25_2 doi: 10.1128/AAC.40.9.2187 – ident: e_1_3_2_53_2 doi: 10.1128/JCM.36.7.1969-1973.1998 – ident: e_1_3_2_27_2 doi: 10.1126/science.118.3063.297 – ident: e_1_3_2_2_2 doi: 10.1128/JCM.38.2.781-788.2000 – ident: e_1_3_2_47_2 doi: 10.1128/JCM.40.10.3789-3792.2002 – ident: e_1_3_2_31_2 doi: 10.1093/infdis/173.1.196 – ident: e_1_3_2_42_2 doi: 10.1128/AAC.41.3.600 – ident: e_1_3_2_46_2 doi: 10.1128/JCM.40.6.1930-1937.2002 – ident: e_1_3_2_28_2 doi: 10.1016/j.mimet.2004.02.006 – ident: e_1_3_2_20_2 doi: 10.1128/AAC.41.9.2057 – ident: e_1_3_2_7_2 doi: 10.1001/jama.1996.03530300036037 – ident: e_1_3_2_54_2 doi: 10.1086/514096 – ident: e_1_3_2_38_2 doi: 10.1046/j.1365-2958.1996.00133.x – volume: 2 start-page: 743 year: 1998 ident: e_1_3_2_11_2 publication-title: Int. J. Tuberc. Lung Dis. – ident: e_1_3_2_43_2 doi: 10.1128/jcm.35.3.719-723.1997 – volume: 17 start-page: 508 year: 1998 ident: e_1_3_2_36_2 publication-title: Eur. J. Clin. Microbiol. Infect. Dis. – ident: e_1_3_2_10_2 doi: 10.1016/0962-8479(95)90009-8 – ident: e_1_3_2_13_2 doi: 10.3201/eid0811.020507 – ident: e_1_3_2_8_2 doi: 10.1016/S0167-7012(00)00175-5 – ident: e_1_3_2_24_2 doi: 10.1128/AAC.42.9.2443 – ident: e_1_3_2_6_2 doi: 10.1016/S0966-842X(01)02277-6 – ident: e_1_3_2_56_2 doi: 10.1038/358591a0 – ident: e_1_3_2_51_2 doi: 10.1086/317598 – ident: e_1_3_2_48_2 doi: 10.1128/jcm.31.2.406-409.1993 – ident: e_1_3_2_18_2 doi: 10.1128/jcm.35.4.907-914.1997 – ident: e_1_3_2_5_2 doi: 10.1054/tube.2002.0332 – ident: e_1_3_2_9_2 – ident: e_1_3_2_50_2 doi: 10.1086/314930 – ident: e_1_3_2_30_2 doi: 10.1093/infdis/171.4.954 – ident: e_1_3_2_55_2 doi: 10.1046/j.1365-2958.1996.449980.x – ident: e_1_3_2_39_2 doi: 10.1128/AAC.39.11.2472 – ident: e_1_3_2_32_2 doi: 10.1093/clinids/24.5.894 – ident: e_1_3_2_40_2 doi: 10.1126/science.272.5268.1641 – ident: e_1_3_2_21_2 doi: 10.1054/tuld.1999.0231 – volume: 119 start-page: 131 year: 1995 ident: e_1_3_2_19_2 publication-title: Arch. Pathol. Lab. Med. – ident: e_1_3_2_22_2 doi: 10.1128/JCM.39.9.3339-3345.2001 – ident: e_1_3_2_3_2 doi: 10.1128/AAC.47.6.2009-2011.2003 – volume: 56 start-page: 173 year: 2001 ident: e_1_3_2_37_2 publication-title: Thorax doi: 10.1136/thorax.56.3.173 – ident: e_1_3_2_17_2 doi: 10.1128/iai.65.4.1395-1401.1997 – ident: e_1_3_2_29_2 doi: 10.1128/AAC.46.5.1417-1424.2002 – ident: e_1_3_2_41_2 doi: 10.1073/pnas.94.18.9869 – ident: e_1_3_2_34_2 doi: 10.1054/tuld.1998.0002 – ident: e_1_3_2_16_2 doi: 10.3201/eid0808.020002 – ident: e_1_3_2_33_2 doi: 10.1128/AAC.44.1.103-110.2000 – ident: e_1_3_2_52_2 doi: 10.1128/jcm.33.12.3234-3238.1995 – volume: 6 start-page: 160 year: 2002 ident: e_1_3_2_45_2 publication-title: Int. J. Tuberc. Lung Dis. – ident: e_1_3_2_4_2 doi: 10.1126/science.8284673 – ident: e_1_3_2_14_2 doi: 10.1056/NEJM200104263441706 – volume: 57 start-page: 562 year: 2002 ident: e_1_3_2_26_2 publication-title: Thorax doi: 10.1136/thorax.57.6.562 – reference: 9119479 - Infect Immun. 1997 Apr;65(4):1395-401 – reference: 7496004 - Tuber Lung Dis. 1995 Oct;76(5):425-30 – reference: 10602730 - Antimicrob Agents Chemother. 2000 Jan;44(1):103-10 – reference: 9041419 - J Clin Microbiol. 1997 Mar;35(3):719-23 – reference: 8537659 - J Infect Dis. 1996 Jan;173(1):196-202 – reference: 9764555 - Eur J Clin Microbiol Infect Dis. 1998 Jul;17(7):508-11 – reference: 8627966 - JAMA. 1996 Feb 14;275(6):452-7 – reference: 8284673 - Science. 1994 Jan 14;263(5144):227-30 – reference: 9142789 - Clin Infect Dis. 1997 May;24(5):894-900 – reference: 12356462 - Tuberculosis (Edinb). 2002;82(2-3):105-12 – reference: 10438361 - J Infect Dis. 1999 Sep;180(3):726-36 – reference: 11931416 - Int J Tuberc Lung Dis. 2002 Feb;6(2):160-3 – reference: 7848059 - Arch Pathol Lab Med. 1995 Feb;119(2):131-8 – reference: 10897383 - Tuber Lung Dis. 2000;80(1):47-56 – reference: 8095569 - Lancet. 1993 Mar 13;341(8846):647-50 – reference: 10655385 - J Clin Microbiol. 2000 Feb;38(2):781-8 – reference: 11526173 - J Clin Microbiol. 2001 Sep;39(9):3339-45 – reference: 11959577 - Antimicrob Agents Chemother. 2002 May;46(5):1417-24 – reference: 12037237 - Thorax. 2002 Jun;57(6):562-3 – reference: 7706824 - J Infect Dis. 1995 Apr;171(4):954-60 – reference: 12406221 - Mol Microbiol. 2002 Oct;46(2):453-66 – reference: 12354882 - J Clin Microbiol. 2002 Oct;40(10):3789-92 – reference: 11320389 - N Engl J Med. 2001 Apr 26;344(17):1294-303 – reference: 12453368 - Emerg Infect Dis. 2002 Nov;8(11):1347-9 – reference: 12654653 - Antimicrob Agents Chemother. 2003 Apr;47(4):1241-50 – reference: 9157152 - J Clin Microbiol. 1997 Apr;35(4):907-14 – reference: 8381814 - J Clin Microbiol. 1993 Feb;31(2):406-9 – reference: 12760887 - Antimicrob Agents Chemother. 2003 Jun;47(6):2009-11 – reference: 12141971 - Emerg Infect Dis. 2002 Aug;8(8):843-9 – reference: 8830260 - Mol Microbiol. 1996 Mar;19(5):1025-34 – reference: 9736581 - Antimicrob Agents Chemother. 1998 Sep;42(9):2443-5 – reference: 1501713 - Nature. 1992 Aug 13;358(6387):591-3 – reference: 11018277 - J Microbiol Methods. 2000 Oct;42(2):203-7 – reference: 12453364 - Emerg Infect Dis. 2002 Nov;8(11):1320-6 – reference: 9275218 - Proc Natl Acad Sci U S A. 1997 Sep 2;94(18):9869-74 – reference: 11755085 - Trends Microbiol. 2002 Jan;10(1):45-52 – reference: 8939440 - Mol Microbiol. 1996 Nov;22(3):583-92 – reference: 8585728 - Antimicrob Agents Chemother. 1995 Nov;39(11):2472-7 – reference: 11182007 - Thorax. 2001 Mar;56(3):173-9 – reference: 9755929 - Int J Tuberc Lung Dis. 1998 Sep;2(9):743-50 – reference: 9056000 - Antimicrob Agents Chemother. 1997 Mar;41(3):600-6 – reference: 11158121 - J Clin Microbiol. 2001 Feb;39(2):636-41 – reference: 9650946 - J Clin Microbiol. 1998 Jul;36(7):1969-73 – reference: 9291321 - J Infect Dis. 1997 Sep;176(3):722-7 – reference: 8586708 - J Clin Microbiol. 1995 Dec;33(12):3234-8 – reference: 12037045 - J Clin Microbiol. 2002 Jun;40(6):1930-7 – reference: 9303417 - Antimicrob Agents Chemother. 1997 Sep;41(9):2057-8 – reference: 13089681 - Science. 1953 Sep 11;118(3063):297-9 – reference: 8878604 - Antimicrob Agents Chemother. 1996 Sep;40(9):2187-9 – reference: 9432394 - Int J Tuberc Lung Dis. 1997 Aug;1(4):365-9 – reference: 10645439 - Tuber Lung Dis. 1998;79(1):3-29 – reference: 11069256 - J Infect Dis. 2000 Dec;182(6):1788-90 – reference: 15134881 - J Microbiol Methods. 2004 Jun;57(3):323-35 – reference: 8658136 - Science. 1996 Jun 14;272(5268):1641-3 |
| SSID | ssj0006590 |
| Score | 2.0842237 |
| Snippet | Classifications
Services
AAC
Citing Articles
Google Scholar
PubMed
Related Content
Social Bookmarking
CiteULike
Delicious
Digg
Facebook
Google+
Mendeley
Reddit... The present study investigated the prevalence and diagnostic potential of the most commonly reported mutations associated with isoniazid resistance, katG... The present study investigated the prevalence and diagnostic potential of the most commonly reported mutations associated with isoniazid resistance, katG... |
| SourceID | pubmedcentral proquest asm2 pubmed pascalfrancis crossref highwire |
| SourceType | Open Access Repository Aggregation Database Index Database Enrichment Source Publisher |
| StartPage | 1455 |
| SubjectTerms | Antibiotics. Antiinfectious agents. Antiparasitic agents Antitubercular Agents Antitubercular Agents - pharmacology Bacterial Proteins - genetics Biological and medical sciences Drug Resistance, Bacterial Drug Resistance, Bacterial - genetics England Humans Isoniazid Isoniazid - pharmacology Mechanisms of Resistance Medical sciences Mycobacterium tuberculosis Mycobacterium tuberculosis - drug effects Mycobacterium tuberculosis - genetics Mycobacterium tuberculosis - isolation & purification Nucleic Acid Hybridization Oligonucleotide Array Sequence Analysis Peroxidases Peroxidases - genetics Peroxiredoxins Pharmacology. Drug treatments Phylogeny Polymorphism, Genetic Sequence Analysis, DNA Wales |
| Title | Molecular Analysis of Isoniazid-Resistant Mycobacterium tuberculosis Isolates from England and Wales Reveals the Phylogenetic Significance of the ahpC −46A Polymorphism |
| URI | http://aac.asm.org/content/49/4/1455.abstract https://www.ncbi.nlm.nih.gov/pubmed/15793126 https://journals.asm.org/doi/10.1128/AAC.49.4.1455-1464.2005 https://www.proquest.com/docview/17846080 https://www.proquest.com/docview/67557199 https://pubmed.ncbi.nlm.nih.gov/PMC1068606 |
| Volume | 49 |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV3db9MwELfKEIgXBOOrA4Yf0F66dPmwneSxmjYNaLcBndhb5CTOWmlNpzVFdH8Q4s_kLnG-UKcBD42q1HZc3S--O_vud4S8jyxlJsoHy02A-cZ45BjSikKDOy6LoliiDYLRFsfi6Ix9POfnnc7PRtTSMgv70c3avJL_kSrcA7liluw_SLYaFG7Ad5AvXEHCcP0rGY_K2rYtbpEPYEJP5c00Nr6oBZqHadYbrSJ4cXNi5uWsly1DdQ0d59gDml-iwVlkmuiiHvmZwjdQHphG8l0hxzJaqKcT8O9hOpj52Ps6vUgx0ChPOtChBnJytd8zmBhgYN1qNgcplhyFFWNzNp1Nc_onpCm4yDPs8uS6iZrpdLA6yULqoI9hFYtb7RuM6xOtkfxRBnefVAFFVWX0wbC1tcEbETF6uRbCYF5Rn7hcrguGUw1L1lh7kXK9ocdBBbD1OsLGvIfBYL_P_D7rYzcDG-cbbLVaLEMBjk-Cw7PhMBgfnI_vkfs2uCNYKePT55qVXvBiL6-cro4jhAft3fIYMADkYma3jaGSoBrjc-UCXtGkqK2yzvn5M4a3YRSNn5DH2puhgwKaT0lHpZvkQVHfdLVJHo505MYm2TktONJXu3Rcp_wtdukOPa3Z01fPyK8K1LQENZ0ndA2oaQvUtAlqWoKaIqipBjXFTw5qqkFNAW-0CWraBDU-FxsgqCmCmjZB_ZycHR6M948MXU7EkJy5mQFCij1pisiVtoCFK0bXIGZmIhIZ-g5XFlPc8T1oLUNhhZHpxImrhB-GwlbSc16QjXSeqleESjNMQjzA5LHDotj0fIvFoA4tC4YSttclBoo30GvFIshdbdsLAA4B8wMWIBzQ7WZYB5Z3iShxEESamx9LxFze3dGsOl4V9DR3d9kqgRbAJAMpo7pZl2y3oFcPKgTWrnO75F2JxQAUEZ4uylTNl_AXXXBlwP-8vYVwOXct3--SlwV269E5mAmWLbrEbaG6aoAk-O1f0ukkJ8O3MMfNFFt3zus1eVSvMW_IRna9VG_BocjC7fxt_g358CIB |
| linkProvider | Colorado Alliance of Research Libraries |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Molecular+Analysis+of+Isoniazid-Resistant+Mycobacterium+tuberculosis+Isolates+from+England+and+Wales+Reveals+the+Phylogenetic+Significance+of+the+ahpC+-46A+Polymorphism&rft.jtitle=Antimicrobial+agents+and+chemotherapy&rft.au=Baker%2C+LV&rft.au=Brown%2C+T+J&rft.au=Maxwell%2C+O&rft.au=Gibson%2C+AL&rft.date=2005-04-01&rft.issn=0066-4804&rft.volume=49&rft.issue=4&rft.spage=1455&rft.epage=1464&rft_id=info:doi/10.1128%2FAAC.49.4.1455-1464.2005&rft.externalDBID=NO_FULL_TEXT |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0066-4804&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0066-4804&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0066-4804&client=summon |