Motors, switches, and contacts in the replisome

• Published in: Annual review of biochemistry Vol. 78; p. 205
• Main Authors: Hamdan, Samir M, Richardson, Charles C
• Format: Journal Article
• Language: English
• Published: United States 01.01.2009
• Subjects: Bacteriophage T4 - genetics; Bacteriophage T4 - metabolism; Bacteriophage T7 - chemistry; Bacteriophage T7 - genetics; Bacteriophage T7 - metabolism; DNA Helicases - genetics; DNA Helicases - metabolism; DNA Replication; DNA, Viral - genetics; DNA, Viral - metabolism; DNA-Directed DNA Polymerase - genetics; DNA-Directed DNA Polymerase - metabolism; Escherichia coli - genetics; Escherichia coli - metabolism; Escherichia coli - virology

Replisomes are the protein assemblies that replicate DNA. They function as molecular motors to catalyze template-mediated polymerization of nucleotides, unwinding of DNA, the synthesis of RNA primers, and the assembly of proteins on DNA. The replisome of bacteriophage T7 contains a minimum of protei...