Structure-Based Stabilization of Non-native Protein–Protein Interactions of Coronavirus Nucleocapsid Proteins in Antiviral Drug Design

• Published in: Journal of medicinal chemistry Vol. 63; no. 6; pp. 3131 - 3141
• Main Authors: Lin, Shan-Meng, Lin, Shih-Chao, Hsu, Jia-Ning, Chang, Chung-ke, Chien, Ching-Ming, Wang, Yong-Sheng, Wu, Hung-Yi, Jeng, U-Ser, Kehn-Hall, Kylene, Hou, Ming-Hon
• Format: Journal Article
• Language: English
• Published: United States American Chemical Society 26.03.2020

Structure-based stabilization of protein–protein interactions (PPIs) is a promising strategy for drug discovery. However, this approach has mainly focused on the stabilization of native PPIs, and non-native PPIs have received little consideration. Here, we identified a non-native interaction interfa...