Design and Synthesis of Potent HIV‑1 Protease Inhibitors Containing Bicyclic Oxazolidinone Scaffold as the P2 Ligands: Structure–Activity Studies and Biological and X‑ray Structural Studies - Ghosh, Arun K; Williams, Jacqueline N; Ho, Rachel Y; Simpson, Hannah M; Hattori, Shin-ichiro; Hayashi, Hironori; Agniswamy, Johnson; Wang, Yuan-Fang; Weber, Irene T; Mitsuya, Hiroaki (Journal of medicinal chemistry, 2018)
Keywords: Antimicrobial agents; BASIC BIOLOGICAL SCIENCES; Catalytic Domain; Chemistry Techniques, Synthetic; Chemistry, Medicinal; Drug Design; HIV Protease - chemistry; HIV Protease - metabolism; HIV Protease Inhibitors - chemical synthesis; HIV Protease Inhibitors - chemistry; HIV Protease Inhibitors - metabolism; HIV Protease Inhibitors - pharmacology; HIV-1 - drug effects; HIV-1 - enzymology; Inhibitors; Life Sciences & Biomedicine; Ligands; Models, Molecular; Oxazolidinones - chemical synthesis; Oxazolidinones - chemistry; Oxazolidinones - metabolism; Oxazolidinones - pharmacology; Peptides and proteins; Pharmacology & Pharmacy; Reaction products; Science & Technology; Stereoisomerism; Structure-Activity Relationship; DIMERIZATION INHIBITION; DARUNAVIR; RESOLUTION CRYSTAL-STRUCTURES; REPLICATION; MECHANISM; VARIANTS; DRUG-RESISTANT MUTANTS; TMC114; ANTIRETROVIRAL THERAPY; BACKBONE