Prolonged Antimicrobial Activity of a Catheter Containing Chlorhexidine-Silver Sulfadiazine Extends Protection against Catheter Infections In Vivo

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Published inAntimicrobial Agents and Chemotherapy Vol. 45; no. 5; pp. 1535 - 1538
Main Authors Bassetti, Stefano, Hu, Jean, D'Agostino, Ralph B, Sherertz, Robert J
Format Journal Article
LanguageEnglish
Published Washington, DC American Society for Microbiology 01.05.2001
Subjects
Animals
Anti-Infective Agents, Local
Anti-Infective Agents, Local - pharmacology
Antibacterial agents
Antibiotics. Antiinfectious agents. Antiparasitic agents
Biological and medical sciences
Catheters, Indwelling
Chlorhexidine
Chlorhexidine - pharmacology
Chlorhexidine - therapeutic use
Disease Models, Animal
Drug Combinations
Experimental Therapeutics
Medical sciences
Microbial Sensitivity Tests
Pharmacology. Drug treatments
Prosthesis-Related Infections
Prosthesis-Related Infections - prevention & control
Rabbits
Silver Sulfadiazine
Silver Sulfadiazine - pharmacology
Silver Sulfadiazine - therapeutic use
Staphylococcal Infections
Staphylococcal Infections - prevention & control
Staphylococcus aureus
Staphylococcus aureus - drug effects
Controlled release form
Catheter
Rabbit
Lagomorpha
In vitro
Biological activity
Infection
Prevention
In vivo
Vertebrata
Mammalia
Animal
Antiinfectious
Chlorhexidine
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Abstract Classifications Services AAC Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit StumbleUpon Twitter current issue AAC About AAC Subscribers Authors Reviewers Advertisers Inquiries from the Press Permissions & Commercial Reprints ASM Journals Public Access Policy AAC RSS Feeds 1752 N Street N.W. • Washington DC 20036 202.737.3600 • 202.942.9355 fax • journals@asmusa.org Print ISSN: 0066-4804 Online ISSN: 1098-6596 Copyright © 2014 by the American Society for Microbiology.   For an alternate route to AAC .asm.org, visit: AAC       
AbstractList ABSTRACT The present study evaluated in vitro and in vivo a new chlorhexidine (C)-silver sulfadiazine (S) vascular catheter (the CS2 catheter) characterized by a higher C content and by the extended release of the surface-bound antimicrobials. The CS2 catheter was compared with a first-generation, commercially available CS catheter (the CS1 catheter). The CS2 catheter produced slightly smaller zones of inhibition (mean difference, 0.9 mm [ P < 0.001]) at 24 h against Staphylococcus aureus and five other microorganisms by several different methodologies. However, in a rabbit model, both CS catheters were similarly efficacious in preventing a catheter infection when the rabbits were inoculated with 10 4 to 10 7 CFU of S. aureus at the time of catheter insertion. The CS2 catheter retained its antimicrobial activity significantly longer in vitro and in vivo (half-lifes exceeded 34 and 7 days, respectively) and was also significantly more efficacious in preventing a catheter infection when 10 6 CFU of S. aureus was inoculated 2 days after catheter implantation ( P < 0.001). These results suggest that prolonged anti-infective activity on the external catheter surface provides improved efficacy in the prevention of infection.
The present study evaluated in vitro and in vivo a new chlorhexidine (C)-silver sulfadiazine (S) vascular catheter (the CS2 catheter) characterized by a higher C content and by the extended release of the surface-bound antimicrobials. The CS2 catheter was compared with a first-generation, commercially available CS catheter (the CS1 catheter). The CS2 catheter produced slightly smaller zones of inhibition (mean difference, 0.9 mm [P < 0.001]) at 24 h against Staphylococcus aureus and five other microorganisms by several different methodologies. However, in a rabbit model, both CS catheters were similarly efficacious in preventing a catheter infection when the rabbits were inoculated with 10(4) to 10(7) CFU of S. aureus at the time of catheter insertion. The CS2 catheter retained its antimicrobial activity significantly longer in vitro and in vivo (half-lives exceeded 34 and 7 days, respectively) and was also significantly more efficacious in preventing a catheter infection when 10(6) CFU of S. aureus was inoculated 2 days after catheter implantation (P < 0.001). These results suggest that prolonged anti-infective activity on the external catheter surface provides improved efficacy in the prevention of infection.
The present study evaluated in vitro and in vivo a new chlorhexidine (C)-silver sulfadiazine (S) vascular catheter (the CS2 catheter) characterized by a higher C content and by the extended release of the surface-bound antimicrobials. The CS2 catheter was compared with a first-generation, commercially available CS catheter (the CS1 catheter). The CS2 catheter produced slightly smaller zones of inhibition (mean difference, 0.9 mm [P < 0.001]) at 24 h against Staphylococcus aureus and five other microorganisms by several different methodologies. However, in a rabbit model, both CS catheters were similarly efficacious in preventing a catheter infection when the rabbits were inoculated with 104 to 107 CFU of S. aureus at the time of catheter insertion. The CS2 catheter retained its antimicrobial activity significantly longer in vitro and in vivo (half-lifes exceeded 34 and 7 days, respectively) and was also significantly more efficacious in preventing a catheter infection when 106 CFU of S. aureus was inoculated 2 days after catheter implantation (P < 0.001). These results suggest that prolonged anti-infective activity on the external catheter surface provides improved efficacy in the prevention of infection.
Classifications Services AAC Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit StumbleUpon Twitter current issue AAC About AAC Subscribers Authors Reviewers Advertisers Inquiries from the Press Permissions & Commercial Reprints ASM Journals Public Access Policy AAC RSS Feeds 1752 N Street N.W. • Washington DC 20036 202.737.3600 • 202.942.9355 fax • journals@asmusa.org Print ISSN: 0066-4804 Online ISSN: 1098-6596 Copyright © 2014 by the American Society for Microbiology.   For an alternate route to AAC .asm.org, visit: AAC       
The present study evaluated in vitro and in vivo a new chlorhexidine (C)-silver sulfadiazine (S) vascular catheter (the CS2 catheter) characterized by a higher C content and by the extended release of the surface-bound antimicrobials. The CS2 catheter was compared with a first-generation, commercially available CS catheter (the CS1 catheter). The CS2 catheter produced slightly smaller zones of inhibition (mean difference, 0.9 mm [P < 0.001]) at 24 h against Staphylococcus aureus and five other microorganisms by several different methodologies. However, in a rabbit model, both CS catheters were similarly efficacious in preventing a catheter infection when the rabbits were inoculated with 10 super(4) to 10 super(7) CFU of S. aureus at the time of catheter insertion. The CS2 catheter retained its antimicrobial activity significantly longer in vitro and in vivo (half-lifes exceeded 34 and 7 days, respectively) and was also significantly more efficacious in preventing a catheter infection when 10 super(6) CFU of S. aureus was inoculated 2 days after catheter implantation (P < 0.001). These results suggest that prolonged anti-infective activity on the external catheter surface provides improved efficacy in the prevention of infection.
The present study evaluated in vitro and in vivo a new chlorhexidine (C)-silver sulfadiazine (S) vascular catheter (the CS2 catheter) characterized by a higher C content and by the extended release of the surface-bound antimicrobials. The CS2 catheter was compared with a first-generation, commercially available CS catheter (the CS1 catheter). The CS2 catheter produced slightly smaller zones of inhibition (mean difference, 0.9 mm [ P < 0.001]) at 24 h against Staphylococcus aureus and five other microorganisms by several different methodologies. However, in a rabbit model, both CS catheters were similarly efficacious in preventing a catheter infection when the rabbits were inoculated with 10 4 to 10 7 CFU of S. aureus at the time of catheter insertion. The CS2 catheter retained its antimicrobial activity significantly longer in vitro and in vivo (half-lifes exceeded 34 and 7 days, respectively) and was also significantly more efficacious in preventing a catheter infection when 10 6 CFU of S. aureus was inoculated 2 days after catheter implantation ( P < 0.001). These results suggest that prolonged anti-infective activity on the external catheter surface provides improved efficacy in the prevention of infection.
Author Ralph B. D'Agostino Jr
Stefano Bassetti
Jean Hu
Robert J. Sherertz
AuthorAffiliation Section on Infectious Diseases 1 and Section on Biostatistics, 2 Wake Forest University School of Medicine, Winston-Salem, North Carolina
AuthorAffiliation_xml – name: Section on Infectious Diseases 1 and Section on Biostatistics, 2 Wake Forest University School of Medicine, Winston-Salem, North Carolina
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  givenname: Stefano
  surname: Bassetti
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  surname: Hu
  fullname: Hu, Jean
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  surname: D'Agostino
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  givenname: Robert J
  surname: Sherertz
  fullname: Sherertz, Robert J
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  organization: Corresponding author. Mailing address: Section on Infectious Diseases, Wake Forest University School of Medicine, Medical Center Boulevard, Winston-Salem, NC 27157-1042. Phone: 716-4584. Fax: 716-3825. E-mail: sherertz@wfubmc.edu
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Issue 5
Keywords Controlled release form
Catheter
Rabbit
Lagomorpha
In vitro
Biological activity
Infection
Prevention
In vivo
Vertebrata
Mammalia
Animal
Antiinfectious
Chlorhexidine
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Present address: Medizinische Universitätsklinik B, Kantonsspital Basel, CH-4031 Basel, Switzerland.
Corresponding author. Mailing address: Section on Infectious Diseases, Wake Forest University School of Medicine, Medical Center Boulevard, Winston-Salem, NC 27157-1042. Phone: (336) 716-4584. Fax: (336) 716-3825. E-mail: sherertz@wfubmc.edu.
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PublicationTitle Antimicrobial Agents and Chemotherapy
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PublicationYear 2001
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The present study evaluated in vitro and in vivo a new chlorhexidine (C)-silver sulfadiazine (S) vascular catheter (the CS2 catheter) characterized by a higher...
ABSTRACT The present study evaluated in vitro and in vivo a new chlorhexidine (C)-silver sulfadiazine (S) vascular catheter (the CS2 catheter) characterized by...
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StartPage 1535
SubjectTerms Animals
Anti-Infective Agents, Local
Anti-Infective Agents, Local - pharmacology
Antibacterial agents
Antibiotics. Antiinfectious agents. Antiparasitic agents
Biological and medical sciences
Catheters, Indwelling
Chlorhexidine
Chlorhexidine - pharmacology
Chlorhexidine - therapeutic use
Disease Models, Animal
Drug Combinations
Experimental Therapeutics
Medical sciences
Microbial Sensitivity Tests
Pharmacology. Drug treatments
Prosthesis-Related Infections
Prosthesis-Related Infections - prevention & control
Rabbits
Silver Sulfadiazine
Silver Sulfadiazine - pharmacology
Silver Sulfadiazine - therapeutic use
Staphylococcal Infections
Staphylococcal Infections - prevention & control
Staphylococcus aureus
Staphylococcus aureus - drug effects
Title Prolonged Antimicrobial Activity of a Catheter Containing Chlorhexidine-Silver Sulfadiazine Extends Protection against Catheter Infections In Vivo
URI http://aac.asm.org/content/45/5/1535.abstract
https://www.ncbi.nlm.nih.gov/pubmed/11302823
https://journals.asm.org/doi/10.1128/AAC.45.5.1535-1538.2001
https://search.proquest.com/docview/17880109
https://search.proquest.com/docview/77052943
https://pubmed.ncbi.nlm.nih.gov/PMC90501
Volume 45
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