Sub-Inhibitory Concentrations of Oxacillin, but Not Clindamycin, Linezolid, or Tigecycline, Decrease Staphylococcal Phenol-Soluble Modulin Expression in Community-Acquired Methicillin-Resistant Staphylococcus aureus

• Published in: Microbiology spectrum Vol. 10; no. 1; p. e0080821
• Main Authors: Hodille, Elisabeth, Beraud, Laetitia, Périan, Séverine, Berti, Valentine, Bes, Michèle, Tristan, Anne, Blond, Emilie, Lina, Gérard, Dumitrescu, Oana
• Format: Journal Article
• Language: English
• Published: United States American Society for Microbiology 23.02.2022
• Subjects: Anti-Bacterial Agents - pharmacology; Bacterial Proteins - genetics; Bacterial Proteins - metabolism; Bacterial Toxins - biosynthesis; Bacteriology; Clindamycin - pharmacology; community-acquired methicillin-resistant Staphylococcus aureus; Gene Expression Regulation, Bacterial - drug effects; Humans; Life Sciences; Linezolid - pharmacology; Methicillin-Resistant Staphylococcus aureus - drug effects; Methicillin-Resistant Staphylococcus aureus - genetics; Methicillin-Resistant Staphylococcus aureus - metabolism; Microbial Sensitivity Tests; Oxacillin - pharmacology; phenol-soluble modulins alpha; Research Article; ST8 USA300 clone; ST80 European clone; Staphylococcal Infections - microbiology; Staphylococcus aureus; Tigecycline - pharmacology; virulence factors; phenol-soluble modulins alpha; community-acquired methicillin-resistant Staphylococcus aureus; ST80 European clone; ST8 USA300 clone; delta-hemolysin; modulation expression; antibiotics; subinhibitory concentration; Staphylococcus aureus; virulence factors

Staphylococcus aureus (SA) is a major human pathogen producing virulence factors, such as Panton-Valentine-leucocidin (PVL), alpha-hemolysin (Hla), and phenol-soluble-modulins alpha (PSMα), including delta-hemolysin (Hld). Unlike oxacillin, clindamycin and linezolid subinhibitory concentrations (sub...