The role of antibodies in HIV vaccines

• Published in: Annual review of immunology Vol. 28; p. 413
• Main Authors: Mascola, John R, Montefiori, David C
• Format: Journal Article
• Language: English
• Published: United States 01.01.2010
• Subjects: AIDS Vaccines - immunology; Animals; Antibodies, Neutralizing - immunology; Drug Design; Epitopes - immunology; HIV Antibodies - immunology; Humans

Licensed vaccines against viral diseases generate antibodies that neutralize the infecting virus and protect against infection or disease. Similarly, an effective vaccine against HIV-1 will likely need to induce antibodies that prevent initial infection of host cells or that limit early events of vi...