Are Quaternary Ammonium Compounds, the Workhorse Disinfectants, Effective against Severe Acute Respiratory Syndrome-Coronavirus-2?

A novel virus named Severe Acute Respiratory Syndrome-Coronavirus-2 (SARS-CoV-2) emerged from Wuhan, China in late 2019. Since then, the virus has quickly spread worldwide, leading the World Health Organization to declare it as a pandemic; by the end of April 2020, the number of cases exceeded 3 mil...

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Published inACS infectious diseases Vol. 6; no. 7; pp. 1553 - 1557
Main Authors Schrank, Cassandra L, Minbiole, Kevin P. C, Wuest, William M
Format Journal Article
LanguageEnglish
Published United States American Chemical Society 10.07.2020
Subjects
Anti-Infective Agents, Local - pharmacology
Benzalkonium Compounds - pharmacology
Betacoronavirus - chemistry
Betacoronavirus - drug effects
Coronavirus Infections - prevention & control
Coronavirus Infections - virology
COVID-19
Disinfectants - pharmacology
Disinfection - methods
Hand Disinfection - methods
Humans
Membrane Lipids
Pandemics - prevention & control
Pneumonia, Viral - prevention & control
Pneumonia, Viral - virology
Sanitation - methods
SARS-CoV-2
Treatment Outcome
Virus Replication - drug effects
Online AccessGet full text

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Abstract A novel virus named Severe Acute Respiratory Syndrome-Coronavirus-2 (SARS-CoV-2) emerged from Wuhan, China in late 2019. Since then, the virus has quickly spread worldwide, leading the World Health Organization to declare it as a pandemic; by the end of April 2020, the number of cases exceeded 3 million. Due to the high infectivity rate, SARS-CoV-2 is difficult to contain, making disinfectant protocols vital, especially for essential, highly trafficked areas such as hospitals, grocery stores, and delivery centers. According to the Centers for Disease Control and Prevention, best practices to slow the spread rely on good hand hygiene, including proper handwashing practices as well as the use of alcohol-based hand sanitizers. However, they provide warning against sanitizing products containing benzalkonium chloride (BAC), which has sparked concern in both the scientific community as well as the general public as BAC, a common quaternary ammonium compound (QAC), is ubiquitous in soaps and cleaning wipes as well as hospital sanitation kits. This viewpoint aims to highlight the outdated and incongruous data in the evaluation of BAC against the family of known coronaviruses and points to the need for further evaluation of the efficacy of QACs against coronaviruses.
AbstractList A novel virus named Severe Acute Respiratory Syndrome-Coronavirus-2 (SARS-CoV-2) emerged from Wuhan, China in late 2019. Since then, the virus has quickly spread worldwide, leading the World Health Organization to declare it as a pandemic; by the end of April 2020, the number of cases exceeded 3 million. Due to the high infectivity rate, SARS-CoV-2 is difficult to contain, making disinfectant protocols vital, especially for essential, highly trafficked areas such as hospitals, grocery stores, and delivery centers. According to the Centers for Disease Control and Prevention, best practices to slow the spread rely on good hand hygiene, including proper handwashing practices as well as the use of alcohol-based hand sanitizers. However, they provide warning against sanitizing products containing benzalkonium chloride (BAC), which has sparked concern in both the scientific community as well as the general public as BAC, a common quaternary ammonium compound (QAC), is ubiquitous in soaps and cleaning wipes as well as hospital sanitation kits. This viewpoint aims to highlight the outdated and incongruous data in the evaluation of BAC against the family of known coronaviruses and points to the need for further evaluation of the efficacy of QACs against coronaviruses.
A novel virus named SARS-CoV-2 emerged from Wuhan, China in late 2019. Since then, the virus has quickly spread worldwide, leading the WHO to declare it as a pandemic; by the end of April 2020, the number of cases exceeded 3 million. Due to the high infectivity rate, SARS-CoV-2 is difficult to contain, making disinfectant protocols vital, especially for essential, highly trafficked areas such as hospitals, grocery stores, and delivery centers. According to the CDC, best practices to slow the spread rely on good hand hygiene, including proper handwashing practices as well as the use of alcohol-based hand sanitizers (ABHS). However, they provide warning against sanitizing products containing benzalkonium chloride (BAC), which has sparked fear in both the scientific community as well as the general public as BAC, a common quaternary ammonium compound (QAC), is ubiquitous in soaps and cleaning wipes, as well as hospital sanitation kits. This viewpoint aims to highlight the outdated and incongruous data in the evaluation of BAC against the family of known coronaviruses, as well as points to the need for further evaluation of the efficacy of QACs against coronaviruses.
A novel virus named Severe Acute Respiratory Syndrome-Coronavirus-2 (SARS-CoV-2) emerged from Wuhan, China in late 2019. Since then, the virus has quickly spread worldwide, leading the World Health Organization to declare it as a pandemic; by the end of April 2020, the number of cases exceeded 3 million. Due to the high infectivity rate, SARS-CoV-2 is difficult to contain, making disinfectant protocols vital, especially for essential, highly trafficked areas such as hospitals, grocery stores, and delivery centers. According to the Centers for Disease Control and Prevention, best practices to slow the spread rely on good hand hygiene, including proper handwashing practices as well as the use of alcohol-based hand sanitizers. However, they provide warning against sanitizing products containing benzalkonium chloride (BAC), which has sparked concern in both the scientific community as well as the general public as BAC, a common quaternary ammonium compound (QAC), is ubiquitous in soaps and cleaning wipes as well as hospital sanitation kits. This viewpoint aims to highlight the outdated and incongruous data in the evaluation of BAC against the family of known coronaviruses and points to the need for further evaluation of the efficacy of QACs against coronaviruses.A novel virus named Severe Acute Respiratory Syndrome-Coronavirus-2 (SARS-CoV-2) emerged from Wuhan, China in late 2019. Since then, the virus has quickly spread worldwide, leading the World Health Organization to declare it as a pandemic; by the end of April 2020, the number of cases exceeded 3 million. Due to the high infectivity rate, SARS-CoV-2 is difficult to contain, making disinfectant protocols vital, especially for essential, highly trafficked areas such as hospitals, grocery stores, and delivery centers. According to the Centers for Disease Control and Prevention, best practices to slow the spread rely on good hand hygiene, including proper handwashing practices as well as the use of alcohol-based hand sanitizers. However, they provide warning against sanitizing products containing benzalkonium chloride (BAC), which has sparked concern in both the scientific community as well as the general public as BAC, a common quaternary ammonium compound (QAC), is ubiquitous in soaps and cleaning wipes as well as hospital sanitation kits. This viewpoint aims to highlight the outdated and incongruous data in the evaluation of BAC against the family of known coronaviruses and points to the need for further evaluation of the efficacy of QACs against coronaviruses.
Author Wuest, William M
Schrank, Cassandra L
Minbiole, Kevin P. C
AuthorAffiliation Department of Chemistry
Emory Antibiotic Resistance Center
Emory University School of Medicine
AuthorAffiliation_xml – name: Emory Antibiotic Resistance Center
– name: Emory University School of Medicine
– name: Department of Chemistry
– name: Department of Chemistry Emory University Atlanta, GA, 30322 USA
– name: Emory Antibiotic Resistance Center, Emory University School of Medicine Atlanta, GA, 30322 USA
– name: Department of Chemistry Villanova University Villanova, PA, 19085 USA
Author_xml – sequence: 1
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  surname: Schrank
  fullname: Schrank, Cassandra L
  organization: Department of Chemistry
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  surname: Minbiole
  fullname: Minbiole, Kevin P. C
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  givenname: William M
  orcidid: 0000-0002-5198-7744
  surname: Wuest
  fullname: Wuest, William M
  email: wwuest@emory.edu
  organization: Emory University School of Medicine
BackLink https://www.ncbi.nlm.nih.gov/pubmed/32412231$$D View this record in MEDLINE/PubMed
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Snippet A novel virus named Severe Acute Respiratory Syndrome-Coronavirus-2 (SARS-CoV-2) emerged from Wuhan, China in late 2019. Since then, the virus has quickly...
A novel virus named SARS-CoV-2 emerged from Wuhan, China in late 2019. Since then, the virus has quickly spread worldwide, leading the WHO to declare it as a...
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SubjectTerms Anti-Infective Agents, Local - pharmacology
Benzalkonium Compounds - pharmacology
Betacoronavirus - chemistry
Betacoronavirus - drug effects
Coronavirus Infections - prevention & control
Coronavirus Infections - virology
COVID-19
Disinfectants - pharmacology
Disinfection - methods
Hand Disinfection - methods
Humans
Membrane Lipids
Pandemics - prevention & control
Pneumonia, Viral - prevention & control
Pneumonia, Viral - virology
Sanitation - methods
SARS-CoV-2
Treatment Outcome
Virus Replication - drug effects
Title Are Quaternary Ammonium Compounds, the Workhorse Disinfectants, Effective against Severe Acute Respiratory Syndrome-Coronavirus-2?
URI http://dx.doi.org/10.1021/acsinfecdis.0c00265
https://www.ncbi.nlm.nih.gov/pubmed/32412231
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