From “Cellular” RNA to “Smart” RNA: Multiple Roles of RNA in Genome Stability and Beyond

• Published in: Chemical reviews Vol. 118; no. 8; pp. 4365 - 4403
• Main Authors: Michelini, Flavia, Jalihal, Ameya P, Francia, Sofia, Meers, Chance, Neeb, Zachary T, Rossiello, Francesca, Gioia, Ubaldo, Aguado, Julio, Jones-Weinert, Corey, Luke, Brian, Biamonti, Giuseppe, Nowacki, Mariusz, Storici, Francesca, Carninci, Piero, Walter, Nils G, d’Adda di Fagagna, Fabrizio
• Format: Journal Article
• Language: English
• Published: United States American Chemical Society 25.04.2018
• Subjects: Biological activity; Biology; Cellular structure; Chemical synthesis; Deoxyribonucleic acid; DNA; Gene expression; Genomes; Interface stability; Modulation; Polypeptides; Proteins; Ribonucleic acid; RNA

Coding for proteins has been considered the main function of RNA since the “central dogma” of biology was proposed. The discovery of noncoding transcripts shed light on additional roles of RNA, ranging from the support of polypeptide synthesis, to the assembly of subnuclear structures, to gene expre...