From “Cellular” RNA to “Smart” RNA: Multiple Roles of RNA in Genome Stability and Beyond

Coding for proteins has been considered the main function of RNA since the “central dogma” of biology was proposed. The discovery of noncoding transcripts shed light on additional roles of RNA, ranging from the support of polypeptide synthesis, to the assembly of subnuclear structures, to gene expre...

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Published inChemical reviews Vol. 118; no. 8; pp. 4365 - 4403
Main Authors Michelini, Flavia, Jalihal, Ameya P, Francia, Sofia, Meers, Chance, Neeb, Zachary T, Rossiello, Francesca, Gioia, Ubaldo, Aguado, Julio, Jones-Weinert, Corey, Luke, Brian, Biamonti, Giuseppe, Nowacki, Mariusz, Storici, Francesca, Carninci, Piero, Walter, Nils G, d’Adda di Fagagna, Fabrizio
Format Journal Article
LanguageEnglish
Published United States American Chemical Society 25.04.2018
Subjects
Biological activity
Biology
Cellular structure
Chemical synthesis
Deoxyribonucleic acid
DNA
Gene expression
Genomes
Interface stability
Modulation
Polypeptides
Proteins
Ribonucleic acid
RNA
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Abstract Coding for proteins has been considered the main function of RNA since the “central dogma” of biology was proposed. The discovery of noncoding transcripts shed light on additional roles of RNA, ranging from the support of polypeptide synthesis, to the assembly of subnuclear structures, to gene expression modulation. Cellular RNA has therefore been recognized as a central player in often unanticipated biological processes, including genomic stability. This ever-expanding list of functions inspired us to think of RNA as a “smart” phone, which has replaced the older obsolete “cellular” phone. In this review, we summarize the last two decades of advances in research on the interface between RNA biology and genome stability. We start with an account of the emergence of noncoding RNA, and then we discuss the involvement of RNA in DNA damage signaling and repair, telomere maintenance, and genomic rearrangements. We continue with the depiction of single-molecule RNA detection techniques, and we conclude by illustrating the possibilities of RNA modulation in hopes of creating or improving new therapies. The widespread biological functions of RNA have made this molecule a reoccurring theme in basic and translational research, warranting it the transcendence from classically studied “cellular” RNA to “smart” RNA.
AbstractList Coding for proteins has been considered the main function of RNA since the "central dogma" of biology was proposed. The discovery of noncoding transcripts shed light on additional roles of RNA, ranging from the support of polypeptide synthesis, to the assembly of subnuclear structures, to gene expression modulation. Cellular RNA has therefore been recognized as a central player in often unanticipated biological processes, including genomic stability. This ever-expanding list of functions inspired us to think of RNA as a "smart" phone, which has replaced the older obsolete "cellular" phone. In this review, we summarize the last two decades of advances in research on the interface between RNA biology and genome stability. We start with an account of the emergence of noncoding RNA, and then we discuss the involvement of RNA in DNA damage signaling and repair, telomere maintenance, and genomic rearrangements. We continue with the depiction of single-molecule RNA detection techniques, and we conclude by illustrating the possibilities of RNA modulation in hopes of creating or improving new therapies. The widespread biological functions of RNA have made this molecule a reoccurring theme in basic and translational research, warranting it the transcendence from classically studied "cellular" RNA to "smart" RNA.
Author Francia, Sofia
Luke, Brian
Nowacki, Mariusz
Walter, Nils G
Carninci, Piero
Biamonti, Giuseppe
Jalihal, Ameya P
Neeb, Zachary T
Storici, Francesca
Rossiello, Francesca
Meers, Chance
Gioia, Ubaldo
d’Adda di Fagagna, Fabrizio
Aguado, Julio
Jones-Weinert, Corey
Michelini, Flavia
AuthorAffiliation University of Michigan
Institute of Cell Biology
University of Bern
Institute of Developmental Biology and Neurobiology
RIKEN Center for Life Science Technologies
School of Biological Sciences
Johannes Gutenberg University
Single Molecule Analysis Group and Center for RNA Biomedicine, Department of Chemistry
Istituto di Genetica Molecolare
CNR - Consiglio Nazionale delle Ricerche
Institute of Molecular Biology (IMB)
Georgia Institute of Technology
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– name: University of Michigan
– name: Single Molecule Analysis Group and Center for RNA Biomedicine, Department of Chemistry
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– name: Istituto di Genetica Molecolare
– name: Institute of Cell Biology
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  surname: d’Adda di Fagagna
  fullname: d’Adda di Fagagna, Fabrizio
  email: fabrizio.dadda@ifom.eu
  organization: CNR - Consiglio Nazionale delle Ricerche
BackLink https://www.ncbi.nlm.nih.gov/pubmed/29600857$$D View this record in MEDLINE/PubMed
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Snippet Coding for proteins has been considered the main function of RNA since the “central dogma” of biology was proposed. The discovery of noncoding transcripts shed...
Coding for proteins has been considered the main function of RNA since the "central dogma" of biology was proposed. The discovery of noncoding transcripts shed...
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SubjectTerms Biological activity
Biology
Cellular structure
Chemical synthesis
Deoxyribonucleic acid
DNA
Gene expression
Genomes
Interface stability
Modulation
Polypeptides
Proteins
Ribonucleic acid
RNA
Title From “Cellular” RNA to “Smart” RNA: Multiple Roles of RNA in Genome Stability and Beyond
URI http://dx.doi.org/10.1021/acs.chemrev.7b00487
https://www.ncbi.nlm.nih.gov/pubmed/29600857
https://www.proquest.com/docview/2099979905
https://search.proquest.com/docview/2020488673
https://pubmed.ncbi.nlm.nih.gov/PMC7717669
Volume 118
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