Assessment of Maternal and Neonatal SARS-CoV-2 Viral Load, Transplacental Antibody Transfer, and Placental Pathology in Pregnancies During the COVID-19 Pandemic

• Published in: JAMA network open Vol. 3; no. 12; p. e2030455
• Main Authors: Edlow, Andrea G., Li, Jonathan Z., Collier, Ai-ris Y., Atyeo, Caroline, James, Kaitlyn E., Boatin, Adeline A., Gray, Kathryn J., Bordt, Evan A., Shook, Lydia L., Yonker, Lael M., Fasano, Alessio, Diouf, Khady, Croul, Natalie, Devane, Samantha, Yockey, Laura J., Lima, Rosiane, Shui, Jessica, Matute, Juan D., Lerou, Paul H., Akinwunmi, Babatunde O., Schmidt, Aaron, Feldman, Jared, Hauser, Blake M., Caradonna, Timothy M., De la Flor, Denis, D’Avino, Paolo, Regan, James, Corry, Heather, Coxen, Kendyll, Fajnzylber, Jesse, Pepin, David, Seaman, Michael S., Barouch, Dan H., Walker, Bruce D., Yu, Xu G., Kaimal, Anjali J., Roberts, Drucilla J., Alter, Galit
• Format: Journal Article
• Language: English
• Published: United States American Medical Association 22.12.2020
• Subjects: Adult; Angiotensin-Converting Enzyme 2 - metabolism; Antibodies; Antibodies, Viral - immunology; Case-Control Studies; Cohort Studies; Coronavirus Nucleocapsid Proteins - immunology; Coronaviruses; COVID-19; COVID-19 - blood; COVID-19 - immunology; COVID-19 - transmission; COVID-19 Serological Testing; Enzymes; Female; Fetal Blood - immunology; Fetal Blood - virology; Humans; Immunity, Maternally-Acquired - immunology; Immunoglobulin G - immunology; Immunoglobulin M - immunology; Infant, Newborn; Infections; Infectious Disease Transmission, Vertical - statistics & numerical data; Influenza; Influenza A virus - immunology; Male; Obstetrics and Gynecology; Online Only; Original Investigation; Phosphoproteins - immunology; Placenta - metabolism; Placenta - pathology; Placenta - virology; Pregnancy; Pregnancy Complications, Infectious - blood; Pregnancy Complications, Infectious - immunology; Prospective Studies; Receptors, Coronavirus - metabolism; RNA, Viral - metabolism; SARS-CoV-2 - immunology; Serine Endopeptidases - metabolism; Severe acute respiratory syndrome coronavirus 2; Severity of Illness Index; Spike Glycoprotein, Coronavirus - immunology; Viral Load; Womens health

Biological data are lacking with respect to risk of vertical transmission and mechanisms of fetoplacental protection in maternal severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. To quantify SARS-CoV-2 viral load in maternal and neonatal biofluids, transplacental passage of ant...