Assessment of Maternal and Neonatal SARS-CoV-2 Viral Load, Transplacental Antibody Transfer, and Placental Pathology in Pregnancies During the COVID-19 Pandemic
Biological data are lacking with respect to risk of vertical transmission and mechanisms of fetoplacental protection in maternal severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. To quantify SARS-CoV-2 viral load in maternal and neonatal biofluids, transplacental passage of ant...
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| Published in | JAMA network open Vol. 3; no. 12; p. e2030455 |
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| Main Authors | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
United States
American Medical Association
22.12.2020
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| Subjects | |
| Online Access | Get full text |
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| Abstract | Biological data are lacking with respect to risk of vertical transmission and mechanisms of fetoplacental protection in maternal severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection.
To quantify SARS-CoV-2 viral load in maternal and neonatal biofluids, transplacental passage of anti-SARS-CoV-2 antibody, and incidence of fetoplacental infection.
This cohort study was conducted among pregnant women presenting for care at 3 tertiary care centers in Boston, Massachusetts. Women with reverse transcription-polymerase chain reaction (RT-PCR) results positive for SARS-CoV-2 were recruited from April 2 to June 13, 2020, and follow-up occurred through July 10, 2020. Contemporaneous participants without SARS-CoV-2 infection were enrolled as a convenience sample from pregnant women with RT-PCR results negative for SARS-CoV-2.
SARS-CoV-2 infection in pregnancy, defined by nasopharyngeal swab RT-PCR.
The main outcomes were SARS-CoV-2 viral load in maternal plasma or respiratory fluids and umbilical cord plasma, quantification of anti-SARS-CoV-2 antibodies in maternal and cord plasma, and presence of SARS-CoV-2 RNA in the placenta.
Among 127 pregnant women enrolled, 64 with RT-PCR results positive for SARS-CoV-2 (mean [SD] age, 31.6 [5.6] years) and 63 with RT-PCR results negative for SARS-CoV-2 (mean [SD] age, 33.9 [5.4] years) provided samples for analysis. Of women with SARS-CoV-2 infection, 23 (36%) were asymptomatic, 22 (34%) had mild disease, 7 (11%) had moderate disease, 10 (16%) had severe disease, and 2 (3%) had critical disease. In viral load analyses among 107 women, there was no detectable viremia in maternal or cord blood and no evidence of vertical transmission. Among 77 neonates tested in whom SARS-CoV-2 antibodies were quantified in cord blood, 1 had detectable immunoglobuilin M to nucleocapsid. Among 88 placentas tested, SARS-CoV-2 RNA was not detected in any. In antibody analyses among 37 women with SARS-CoV-2 infection, anti-receptor binding domain immunoglobin G was detected in 24 women (65%) and anti-nucleocapsid was detected in 26 women (70%). Mother-to-neonate transfer of anti-SARS-CoV-2 antibodies was significantly lower than transfer of anti-influenza hemagglutinin A antibodies (mean [SD] cord-to-maternal ratio: anti-receptor binding domain immunoglobin G, 0.72 [0.57]; anti-nucleocapsid, 0.74 [0.44]; anti-influenza, 1.44 [0.80]; P < .001). Nonoverlapping placental expression of SARS-CoV-2 receptors angiotensin-converting enzyme 2 and transmembrane serine protease 2 was noted.
In this cohort study, there was no evidence of placental infection or definitive vertical transmission of SARS-CoV-2. Transplacental transfer of anti-SARS-CoV-2 antibodies was inefficient. Lack of viremia and reduced coexpression and colocalization of placental angiotensin-converting enzyme 2 and transmembrane serine protease 2 may serve as protective mechanisms against vertical transmission. |
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| AbstractList | Biological data are lacking with respect to risk of vertical transmission and mechanisms of fetoplacental protection in maternal severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection.ImportanceBiological data are lacking with respect to risk of vertical transmission and mechanisms of fetoplacental protection in maternal severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection.To quantify SARS-CoV-2 viral load in maternal and neonatal biofluids, transplacental passage of anti-SARS-CoV-2 antibody, and incidence of fetoplacental infection.ObjectiveTo quantify SARS-CoV-2 viral load in maternal and neonatal biofluids, transplacental passage of anti-SARS-CoV-2 antibody, and incidence of fetoplacental infection.This cohort study was conducted among pregnant women presenting for care at 3 tertiary care centers in Boston, Massachusetts. Women with reverse transcription-polymerase chain reaction (RT-PCR) results positive for SARS-CoV-2 were recruited from April 2 to June 13, 2020, and follow-up occurred through July 10, 2020. Contemporaneous participants without SARS-CoV-2 infection were enrolled as a convenience sample from pregnant women with RT-PCR results negative for SARS-CoV-2.Design, Setting, and ParticipantsThis cohort study was conducted among pregnant women presenting for care at 3 tertiary care centers in Boston, Massachusetts. Women with reverse transcription-polymerase chain reaction (RT-PCR) results positive for SARS-CoV-2 were recruited from April 2 to June 13, 2020, and follow-up occurred through July 10, 2020. Contemporaneous participants without SARS-CoV-2 infection were enrolled as a convenience sample from pregnant women with RT-PCR results negative for SARS-CoV-2.SARS-CoV-2 infection in pregnancy, defined by nasopharyngeal swab RT-PCR.ExposuresSARS-CoV-2 infection in pregnancy, defined by nasopharyngeal swab RT-PCR.The main outcomes were SARS-CoV-2 viral load in maternal plasma or respiratory fluids and umbilical cord plasma, quantification of anti-SARS-CoV-2 antibodies in maternal and cord plasma, and presence of SARS-CoV-2 RNA in the placenta.Main Outcomes and MeasuresThe main outcomes were SARS-CoV-2 viral load in maternal plasma or respiratory fluids and umbilical cord plasma, quantification of anti-SARS-CoV-2 antibodies in maternal and cord plasma, and presence of SARS-CoV-2 RNA in the placenta.Among 127 pregnant women enrolled, 64 with RT-PCR results positive for SARS-CoV-2 (mean [SD] age, 31.6 [5.6] years) and 63 with RT-PCR results negative for SARS-CoV-2 (mean [SD] age, 33.9 [5.4] years) provided samples for analysis. Of women with SARS-CoV-2 infection, 23 (36%) were asymptomatic, 22 (34%) had mild disease, 7 (11%) had moderate disease, 10 (16%) had severe disease, and 2 (3%) had critical disease. In viral load analyses among 107 women, there was no detectable viremia in maternal or cord blood and no evidence of vertical transmission. Among 77 neonates tested in whom SARS-CoV-2 antibodies were quantified in cord blood, 1 had detectable immunoglobuilin M to nucleocapsid. Among 88 placentas tested, SARS-CoV-2 RNA was not detected in any. In antibody analyses among 37 women with SARS-CoV-2 infection, anti-receptor binding domain immunoglobin G was detected in 24 women (65%) and anti-nucleocapsid was detected in 26 women (70%). Mother-to-neonate transfer of anti-SARS-CoV-2 antibodies was significantly lower than transfer of anti-influenza hemagglutinin A antibodies (mean [SD] cord-to-maternal ratio: anti-receptor binding domain immunoglobin G, 0.72 [0.57]; anti-nucleocapsid, 0.74 [0.44]; anti-influenza, 1.44 [0.80]; P < .001). Nonoverlapping placental expression of SARS-CoV-2 receptors angiotensin-converting enzyme 2 and transmembrane serine protease 2 was noted.ResultsAmong 127 pregnant women enrolled, 64 with RT-PCR results positive for SARS-CoV-2 (mean [SD] age, 31.6 [5.6] years) and 63 with RT-PCR results negative for SARS-CoV-2 (mean [SD] age, 33.9 [5.4] years) provided samples for analysis. Of women with SARS-CoV-2 infection, 23 (36%) were asymptomatic, 22 (34%) had mild disease, 7 (11%) had moderate disease, 10 (16%) had severe disease, and 2 (3%) had critical disease. In viral load analyses among 107 women, there was no detectable viremia in maternal or cord blood and no evidence of vertical transmission. Among 77 neonates tested in whom SARS-CoV-2 antibodies were quantified in cord blood, 1 had detectable immunoglobuilin M to nucleocapsid. Among 88 placentas tested, SARS-CoV-2 RNA was not detected in any. In antibody analyses among 37 women with SARS-CoV-2 infection, anti-receptor binding domain immunoglobin G was detected in 24 women (65%) and anti-nucleocapsid was detected in 26 women (70%). Mother-to-neonate transfer of anti-SARS-CoV-2 antibodies was significantly lower than transfer of anti-influenza hemagglutinin A antibodies (mean [SD] cord-to-maternal ratio: anti-receptor binding domain immunoglobin G, 0.72 [0.57]; anti-nucleocapsid, 0.74 [0.44]; anti-influenza, 1.44 [0.80]; P < .001). Nonoverlapping placental expression of SARS-CoV-2 receptors angiotensin-converting enzyme 2 and transmembrane serine protease 2 was noted.In this cohort study, there was no evidence of placental infection or definitive vertical transmission of SARS-CoV-2. Transplacental transfer of anti-SARS-CoV-2 antibodies was inefficient. Lack of viremia and reduced coexpression and colocalization of placental angiotensin-converting enzyme 2 and transmembrane serine protease 2 may serve as protective mechanisms against vertical transmission.Conclusions and RelevanceIn this cohort study, there was no evidence of placental infection or definitive vertical transmission of SARS-CoV-2. Transplacental transfer of anti-SARS-CoV-2 antibodies was inefficient. Lack of viremia and reduced coexpression and colocalization of placental angiotensin-converting enzyme 2 and transmembrane serine protease 2 may serve as protective mechanisms against vertical transmission. This cohort study examines maternal and neonatal severe acute respiratory syndrome coronavirus 2 viral load, transplacental antibody transfer, and placental pathology among pregnant women. Importance Biological data are lacking with respect to risk of vertical transmission and mechanisms of fetoplacental protection in maternal severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. Objective To quantify SARS-CoV-2 viral load in maternal and neonatal biofluids, transplacental passage of anti–SARS-CoV-2 antibody, and incidence of fetoplacental infection. Design, Setting, and Participants This cohort study was conducted among pregnant women presenting for care at 3 tertiary care centers in Boston, Massachusetts. Women with reverse transcription–polymerase chain reaction (RT-PCR) results positive for SARS-CoV-2 were recruited from April 2 to June 13, 2020, and follow-up occurred through July 10, 2020. Contemporaneous participants without SARS-CoV-2 infection were enrolled as a convenience sample from pregnant women with RT-PCR results negative for SARS-CoV-2. Exposures SARS-CoV-2 infection in pregnancy, defined by nasopharyngeal swab RT-PCR. Main Outcomes and Measures The main outcomes were SARS-CoV-2 viral load in maternal plasma or respiratory fluids and umbilical cord plasma, quantification of anti–SARS-CoV-2 antibodies in maternal and cord plasma, and presence of SARS-CoV-2 RNA in the placenta. Results Among 127 pregnant women enrolled, 64 with RT-PCR results positive for SARS-CoV-2 (mean [SD] age, 31.6 [5.6] years) and 63 with RT-PCR results negative for SARS-CoV-2 (mean [SD] age, 33.9 [5.4] years) provided samples for analysis. Of women with SARS-CoV-2 infection, 23 (36%) were asymptomatic, 22 (34%) had mild disease, 7 (11%) had moderate disease, 10 (16%) had severe disease, and 2 (3%) had critical disease. In viral load analyses among 107 women, there was no detectable viremia in maternal or cord blood and no evidence of vertical transmission. Among 77 neonates tested in whom SARS-CoV-2 antibodies were quantified in cord blood, 1 had detectable immunoglobuilin M to nucleocapsid. Among 88 placentas tested, SARS-CoV-2 RNA was not detected in any. In antibody analyses among 37 women with SARS-CoV-2 infection, anti–receptor binding domain immunoglobin G was detected in 24 women (65%) and anti-nucleocapsid was detected in 26 women (70%). Mother-to-neonate transfer of anti–SARS-CoV-2 antibodies was significantly lower than transfer of anti-influenza hemagglutinin A antibodies (mean [SD] cord-to-maternal ratio: anti–receptor binding domain immunoglobin G, 0.72 [0.57]; anti-nucleocapsid, 0.74 [0.44]; anti-influenza, 1.44 [0.80];P < .001). Nonoverlapping placental expression of SARS-CoV-2 receptors angiotensin-converting enzyme 2 and transmembrane serine protease 2 was noted. Conclusions and Relevance In this cohort study, there was no evidence of placental infection or definitive vertical transmission of SARS-CoV-2. Transplacental transfer of anti-SARS-CoV-2 antibodies was inefficient. Lack of viremia and reduced coexpression and colocalization of placental angiotensin-converting enzyme 2 and transmembrane serine protease 2 may serve as protective mechanisms against vertical transmission. Biological data are lacking with respect to risk of vertical transmission and mechanisms of fetoplacental protection in maternal severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. To quantify SARS-CoV-2 viral load in maternal and neonatal biofluids, transplacental passage of anti-SARS-CoV-2 antibody, and incidence of fetoplacental infection. This cohort study was conducted among pregnant women presenting for care at 3 tertiary care centers in Boston, Massachusetts. Women with reverse transcription-polymerase chain reaction (RT-PCR) results positive for SARS-CoV-2 were recruited from April 2 to June 13, 2020, and follow-up occurred through July 10, 2020. Contemporaneous participants without SARS-CoV-2 infection were enrolled as a convenience sample from pregnant women with RT-PCR results negative for SARS-CoV-2. SARS-CoV-2 infection in pregnancy, defined by nasopharyngeal swab RT-PCR. The main outcomes were SARS-CoV-2 viral load in maternal plasma or respiratory fluids and umbilical cord plasma, quantification of anti-SARS-CoV-2 antibodies in maternal and cord plasma, and presence of SARS-CoV-2 RNA in the placenta. Among 127 pregnant women enrolled, 64 with RT-PCR results positive for SARS-CoV-2 (mean [SD] age, 31.6 [5.6] years) and 63 with RT-PCR results negative for SARS-CoV-2 (mean [SD] age, 33.9 [5.4] years) provided samples for analysis. Of women with SARS-CoV-2 infection, 23 (36%) were asymptomatic, 22 (34%) had mild disease, 7 (11%) had moderate disease, 10 (16%) had severe disease, and 2 (3%) had critical disease. In viral load analyses among 107 women, there was no detectable viremia in maternal or cord blood and no evidence of vertical transmission. Among 77 neonates tested in whom SARS-CoV-2 antibodies were quantified in cord blood, 1 had detectable immunoglobuilin M to nucleocapsid. Among 88 placentas tested, SARS-CoV-2 RNA was not detected in any. In antibody analyses among 37 women with SARS-CoV-2 infection, anti-receptor binding domain immunoglobin G was detected in 24 women (65%) and anti-nucleocapsid was detected in 26 women (70%). Mother-to-neonate transfer of anti-SARS-CoV-2 antibodies was significantly lower than transfer of anti-influenza hemagglutinin A antibodies (mean [SD] cord-to-maternal ratio: anti-receptor binding domain immunoglobin G, 0.72 [0.57]; anti-nucleocapsid, 0.74 [0.44]; anti-influenza, 1.44 [0.80]; P < .001). Nonoverlapping placental expression of SARS-CoV-2 receptors angiotensin-converting enzyme 2 and transmembrane serine protease 2 was noted. In this cohort study, there was no evidence of placental infection or definitive vertical transmission of SARS-CoV-2. Transplacental transfer of anti-SARS-CoV-2 antibodies was inefficient. Lack of viremia and reduced coexpression and colocalization of placental angiotensin-converting enzyme 2 and transmembrane serine protease 2 may serve as protective mechanisms against vertical transmission. |
| Author | Atyeo, Caroline Matute, Juan D. Shook, Lydia L. Schmidt, Aaron Lerou, Paul H. Collier, Ai-ris Y. Edlow, Andrea G. Pepin, David Croul, Natalie Hauser, Blake M. Devane, Samantha Lima, Rosiane James, Kaitlyn E. Walker, Bruce D. Corry, Heather Yu, Xu G. Alter, Galit Yockey, Laura J. Gray, Kathryn J. Diouf, Khady Fasano, Alessio Akinwunmi, Babatunde O. Fajnzylber, Jesse Kaimal, Anjali J. Feldman, Jared Caradonna, Timothy M. Regan, James Yonker, Lael M. Barouch, Dan H. Boatin, Adeline A. Shui, Jessica Seaman, Michael S. Bordt, Evan A. De la Flor, Denis D’Avino, Paolo Li, Jonathan Z. Roberts, Drucilla J. Coxen, Kendyll |
| AuthorAffiliation | 1 Department of Obstetrics, Gynecology and Reproductive Biology, Massachusetts General Hospital, Harvard Medical School, Boston 4 Department of Obstetrics, Gynecology and Reproductive Biology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 8 Department of Pediatrics, Lurie Center for Autism, Massachusetts General Hospital, Harvard Medical School, Boston 10 Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston 6 Ragon Institute of MGH, MIT and Harvard, Harvard Medical School, Cambridge, Massachusetts 2 Vincent Center for Reproductive Biology, Massachusetts General Hospital, Boston 13 Department of Pathology, Massachusetts General Hospital, Harvard Medical School, Boston 5 Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 12 Pediatric Surgical Research Laboratories, Department of Surgery, Massachusetts General Hospital, Harvard Medical School, Boston 9 |
| AuthorAffiliation_xml | – name: 3 Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School, Boston, Massachusetts – name: 5 Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts – name: 1 Department of Obstetrics, Gynecology and Reproductive Biology, Massachusetts General Hospital, Harvard Medical School, Boston – name: 7 Department of Obstetrics, Gynecology and Reproductive Biology, Brigham and Women’s Hospital, Harvard Medical School, Boston, Massachusetts – name: 9 Department of Pediatrics, Massachusetts General Hospital, Harvard Medical School, Boston – name: 6 Ragon Institute of MGH, MIT and Harvard, Harvard Medical School, Cambridge, Massachusetts – name: 11 Department of Microbiology, Harvard Medical School, Boston, Massachusetts – name: 8 Department of Pediatrics, Lurie Center for Autism, Massachusetts General Hospital, Harvard Medical School, Boston – name: 4 Department of Obstetrics, Gynecology and Reproductive Biology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts – name: 13 Department of Pathology, Massachusetts General Hospital, Harvard Medical School, Boston – name: 2 Vincent Center for Reproductive Biology, Massachusetts General Hospital, Boston – name: 12 Pediatric Surgical Research Laboratories, Department of Surgery, Massachusetts General Hospital, Harvard Medical School, Boston – name: 10 Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston |
| Author_xml | – sequence: 1 givenname: Andrea G. surname: Edlow fullname: Edlow, Andrea G. organization: Department of Obstetrics, Gynecology and Reproductive Biology, Massachusetts General Hospital, Harvard Medical School, Boston, Vincent Center for Reproductive Biology, Massachusetts General Hospital, Boston – sequence: 2 givenname: Jonathan Z. surname: Li fullname: Li, Jonathan Z. organization: Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School, Boston, Massachusetts – sequence: 3 givenname: Ai-ris Y. surname: Collier fullname: Collier, Ai-ris Y. organization: Department of Obstetrics, Gynecology and Reproductive Biology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts – sequence: 4 givenname: Caroline surname: Atyeo fullname: Atyeo, Caroline organization: Ragon Institute of MGH, MIT and Harvard, Harvard Medical School, Cambridge, Massachusetts – sequence: 5 givenname: Kaitlyn E. surname: James fullname: James, Kaitlyn E. organization: Department of Obstetrics, Gynecology and Reproductive Biology, Massachusetts General Hospital, Harvard Medical School, Boston – sequence: 6 givenname: Adeline A. surname: Boatin fullname: Boatin, Adeline A. organization: Department of Obstetrics, Gynecology and Reproductive Biology, Massachusetts General Hospital, Harvard Medical School, Boston – sequence: 7 givenname: Kathryn J. surname: Gray fullname: Gray, Kathryn J. organization: Department of Obstetrics, Gynecology and Reproductive Biology, Brigham and Women’s Hospital, Harvard Medical School, Boston, Massachusetts – sequence: 8 givenname: Evan A. surname: Bordt fullname: Bordt, Evan A. organization: Department of Pediatrics, Lurie Center for Autism, Massachusetts General Hospital, Harvard Medical School, Boston – sequence: 9 givenname: Lydia L. surname: Shook fullname: Shook, Lydia L. organization: Department of Obstetrics, Gynecology and Reproductive Biology, Massachusetts General Hospital, Harvard Medical School, Boston – sequence: 10 givenname: Lael M. surname: Yonker fullname: Yonker, Lael M. organization: Department of Pediatrics, Massachusetts General Hospital, Harvard Medical School, Boston – sequence: 11 givenname: Alessio surname: Fasano fullname: Fasano, Alessio organization: Department of Pediatrics, Massachusetts General Hospital, Harvard Medical School, Boston – sequence: 12 givenname: Khady surname: Diouf fullname: Diouf, Khady organization: Department of Obstetrics, Gynecology and Reproductive Biology, Brigham and Women’s Hospital, Harvard Medical School, Boston, Massachusetts – sequence: 13 givenname: Natalie surname: Croul fullname: Croul, Natalie organization: Department of Obstetrics, Gynecology and Reproductive Biology, Massachusetts General Hospital, Harvard Medical School, Boston – sequence: 14 givenname: Samantha surname: Devane fullname: Devane, Samantha organization: Department of Pediatrics, Massachusetts General Hospital, Harvard Medical School, Boston – sequence: 15 givenname: Laura J. surname: Yockey fullname: Yockey, Laura J. organization: Department of Obstetrics, Gynecology and Reproductive Biology, Massachusetts General Hospital, Harvard Medical School, Boston, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston – sequence: 16 givenname: Rosiane surname: Lima fullname: Lima, Rosiane organization: Department of Pediatrics, Massachusetts General Hospital, Harvard Medical School, Boston – sequence: 17 givenname: Jessica surname: Shui fullname: Shui, Jessica organization: Department of Pediatrics, Massachusetts General Hospital, Harvard Medical School, Boston – sequence: 18 givenname: Juan D. surname: Matute fullname: Matute, Juan D. organization: Department of Pediatrics, Massachusetts General Hospital, Harvard Medical School, Boston – sequence: 19 givenname: Paul H. surname: Lerou fullname: Lerou, Paul H. organization: Department of Pediatrics, Massachusetts General Hospital, Harvard Medical School, Boston – sequence: 20 givenname: Babatunde O. surname: Akinwunmi fullname: Akinwunmi, Babatunde O. organization: Department of Obstetrics, Gynecology and Reproductive Biology, Brigham and Women’s Hospital, Harvard Medical School, Boston, Massachusetts – sequence: 21 givenname: Aaron surname: Schmidt fullname: Schmidt, Aaron organization: Ragon Institute of MGH, MIT and Harvard, Harvard Medical School, Cambridge, Massachusetts, Department of Microbiology, Harvard Medical School, Boston, Massachusetts – sequence: 22 givenname: Jared surname: Feldman fullname: Feldman, Jared organization: Ragon Institute of MGH, MIT and Harvard, Harvard Medical School, Cambridge, Massachusetts – sequence: 23 givenname: Blake M. surname: Hauser fullname: Hauser, Blake M. organization: Ragon Institute of MGH, MIT and Harvard, Harvard Medical School, Cambridge, Massachusetts – sequence: 24 givenname: Timothy M. surname: Caradonna fullname: Caradonna, Timothy M. organization: Ragon Institute of MGH, MIT and Harvard, Harvard Medical School, Cambridge, Massachusetts – sequence: 25 givenname: Denis surname: De la Flor fullname: De la Flor, Denis organization: Department of Pediatrics, Massachusetts General Hospital, Harvard Medical School, Boston – sequence: 26 givenname: Paolo surname: D’Avino fullname: D’Avino, Paolo organization: Department of Pediatrics, Massachusetts General Hospital, Harvard Medical School, Boston – sequence: 27 givenname: James surname: Regan fullname: Regan, James organization: Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School, Boston, Massachusetts – sequence: 28 givenname: Heather surname: Corry fullname: Corry, Heather organization: Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School, Boston, Massachusetts – sequence: 29 givenname: Kendyll surname: Coxen fullname: Coxen, Kendyll organization: Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School, Boston, Massachusetts – sequence: 30 givenname: Jesse surname: Fajnzylber fullname: Fajnzylber, Jesse organization: Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School, Boston, Massachusetts – sequence: 31 givenname: David surname: Pepin fullname: Pepin, David organization: Pediatric Surgical Research Laboratories, Department of Surgery, Massachusetts General Hospital, Harvard Medical School, Boston – sequence: 32 givenname: Michael S. surname: Seaman fullname: Seaman, Michael S. organization: Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts – sequence: 33 givenname: Dan H. surname: Barouch fullname: Barouch, Dan H. organization: Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, Ragon Institute of MGH, MIT and Harvard, Harvard Medical School, Cambridge, Massachusetts – sequence: 34 givenname: Bruce D. surname: Walker fullname: Walker, Bruce D. organization: Ragon Institute of MGH, MIT and Harvard, Harvard Medical School, Cambridge, Massachusetts – sequence: 35 givenname: Xu G. surname: Yu fullname: Yu, Xu G. organization: Ragon Institute of MGH, MIT and Harvard, Harvard Medical School, Cambridge, Massachusetts, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston – sequence: 36 givenname: Anjali J. surname: Kaimal fullname: Kaimal, Anjali J. organization: Department of Obstetrics, Gynecology and Reproductive Biology, Massachusetts General Hospital, Harvard Medical School, Boston – sequence: 37 givenname: Drucilla J. surname: Roberts fullname: Roberts, Drucilla J. organization: Department of Pathology, Massachusetts General Hospital, Harvard Medical School, Boston – sequence: 38 givenname: Galit surname: Alter fullname: Alter, Galit organization: Ragon Institute of MGH, MIT and Harvard, Harvard Medical School, Cambridge, Massachusetts |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/33351086$$D View this record in MEDLINE/PubMed |
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| Cites_doi | 10.1172/JCI139569 10.1128/CDLI.1.6.667-669.1994 10.1086/522498 10.7554/eLife.58716 10.1128/CVI.00270-15 10.1093/cid/ciaa1411 10.1093/infdis/jiw143 10.1017/S0950268899002046 10.1101/2020.07.15.20131789 10.3389/fnbeh.2018.00230 10.1111/cei.2019.195.issue-2 10.1016/j.vaccine.2014.08.038 10.1086/jid.2004.190.issue-2 10.1055/s-0040-1710050 10.3390/v12020194 10.1111/aji.13288 10.15585/mmwr.mm6925a1 10.1016/j.ajog.2020.03.021 10.1016/j.ajog.2016.07.050 10.1016/j.it.2018.08.008 10.1126/science.aag3194 10.1016/S0140-6736(20)30360-3 10.1097/INF.0b013e318193ead7 10.1093/cid/ciw027 10.1016/j.ajog.2020.04.039 10.1038/s41379-020-0639-4 10.3389/fimmu.2018.02186 10.1371/journal.pntd.0007246 10.1016/j.ajogmf.2020.100133 10.1002/bdrb.v86:4 10.1001/jama.2014.3633 10.4269/ajtmh.2005.73.1063 10.1016/j.cell.2020.02.052 10.1097/AOG.0000000000002199 10.1086/522499 10.1001/jama.2020.12746 10.1086/jid.2006.194.issue-11 10.1016/j.jmoldx.2011.08.002 10.15585/mmwr.mm6932e3 10.1056/NEJMc2016321 10.1016/j.jri.2020.103122 10.1073/pnas.1416569111 10.1016/S0140-6736(20)30183-5 10.1371/journal.pntd.0007648 10.1128/JCM.00721-20 10.1097/AOG.0000000000004005 10.1038/s41467-020-17436-6 10.1093/ajcp/aqaa089 10.1002/ijgo.13300 10.1038/s41586-020-2196-x 10.3201/eid2610.202328 10.3389/fimmu.2020.01672 10.5858/arpa.2015-0225-CC 10.1093/ofid/ofz237 10.1177/1093526620925569 10.1093/cid/ciaa848 10.7554/eLife.46349 |
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| References | Chen (zoi200960r16) 2020; 49 zoi200960r27 Kilpatrick (zoi200960r24) 2016; 215 zoi200960r26 Wölfel (zoi200960r38) 2020; 581 Huang (zoi200960r35) 2020; 395 Ciobanu (zoi200960r59) 2020; 10 Shanes (zoi200960r15) 2020; 154 Saatcioglu (zoi200960r29) 2019; 8 Garty (zoi200960r58) 1994; 1 Singh (zoi200960r66) 2019; 13 Ogolla (zoi200960r51) 2015; 22 Wells (zoi200960r37) 2018; 39 Pengsaa (zoi200960r48) 2006; 194 Takemoto (zoi200960r3) 2020 Khong (zoi200960r28) 2016; 140 Ray (zoi200960r52) 2019; 6 Flaherman (zoi200960r33) 2020 Péré (zoi200960r40) 2020; 58 Jamal (zoi200960r39) 2020 Castanha (zoi200960r64) 2019; 13 Alberca (zoi200960r6) 2020; 11 Wang (zoi200960r30) 2012; 14 Vivanti (zoi200960r20) 2020; 11 Hammond (zoi200960r47) 2005; 73 Dong (zoi200960r10) 2020; 323 Gao (zoi200960r46) 2020; 26 Healy (zoi200960r63) 2004; 190 Alzamora (zoi200960r18) 2020; 37 Gonçalves (zoi200960r43) 1999; 122 Wang (zoi200960r42) 2020; 323 Pentsuk (zoi200960r57) 2009; 86 Estes (zoi200960r69) 2016; 353 Goldfarb (zoi200960r56) 2020; 136 Chen (zoi200960r9) 2020; 395 Lamouroux (zoi200960r17) 2020; 223 Ellington (zoi200960r1) 2020; 69 Chen (zoi200960r34) 2020 Zhong (zoi200960r60) 2019; 195 Eberhardt (zoi200960r62) 2016; 62 Patanè (zoi200960r13) 2020 Baergen (zoi200960r8) 2020; 23 Simmons (zoi200960r49) 2007; 196 Kim (zoi200960r53) 2020; 69 Boulanger-Bertolus (zoi200960r68) 2018; 12 Dashraath (zoi200960r5) 2020; 222 Munoz (zoi200960r45) 2014; 311 zoi200960r12 Pique-Regi (zoi200960r55) 2020; 9 zoi200960r11 Zeng (zoi200960r19) 2020; 323 Schwartz (zoi200960r7) 2020; 12 Schepanski (zoi200960r70) 2018; 9 Castanha (zoi200960r67) 2016; 214 Chauhan (zoi200960r25) 2017; 130 Kay (zoi200960r36) 2014; 111 Hoffmann (zoi200960r32) 2020; 181 Cumberland (zoi200960r50) 2007; 196 Ben-Hur (zoi200960r54) 2005; 16 Heininger (zoi200960r44) 2009; 28 Abu Raya (zoi200960r61) 2014; 32 Khalil (zoi200960r2) 2020; 324 Liu (zoi200960r4) 2020; 139 Collier (zoi200960r65) 2020 zoi200960r23 Tu (zoi200960r41) 2020; 383 zoi200960r22 Hecht (zoi200960r31) 2020; 33 zoi200960r21 Penfield (zoi200960r14) 2020 33351080 - JAMA Netw Open. 2020 Dec 1;3(12):e2030564 |
| References_xml | – volume: 10 start-page: 10 issue: 8 year: 2020 ident: zoi200960r59 article-title: Benefits and risks of IgG transplacental transfer. publication-title: Diagnostics (Basel) – ident: zoi200960r12 doi: 10.1172/JCI139569 – volume: 1 start-page: 667 issue: 6 year: 1994 ident: zoi200960r58 article-title: Placental transfer of immunoglobulin G subclasses. publication-title: Clin Diagn Lab Immunol doi: 10.1128/CDLI.1.6.667-669.1994 – volume: 196 start-page: 416 issue: 3 year: 2007 ident: zoi200960r49 article-title: Maternal antibody and viral factors in the pathogenesis of dengue virus in infants. publication-title: J Infect Dis doi: 10.1086/522498 – volume: 9 year: 2020 ident: zoi200960r55 article-title: Does the human placenta express the canonical cell entry mediators for SARS-CoV-2? publication-title: Elife doi: 10.7554/eLife.58716 – volume: 22 start-page: 1197 issue: 11 year: 2015 ident: zoi200960r51 article-title: Reduced transplacental transfer of a subset of Epstein-Barr virus-specific antibodies to neonates of mothers infected with Plasmodium falciparum malaria during pregnancy. publication-title: Clin Vaccine Immunol doi: 10.1128/CVI.00270-15 – year: 2020 ident: zoi200960r33 article-title: Infant outcomes following maternal infection with SARS-CoV-2: first report from the PRIORITY Study. publication-title: Clin Infect Dis doi: 10.1093/cid/ciaa1411 – volume: 214 start-page: 265 issue: 2 year: 2016 ident: zoi200960r67 article-title: Placental transfer of dengue virus (DENV)-specific antibodies and kinetics of DENV infection-enhancing activity in Brazilian infants. publication-title: J Infect Dis doi: 10.1093/infdis/jiw143 – volume: 122 start-page: 273 issue: 2 year: 1999 ident: zoi200960r43 article-title: Transplacental transfer of measles and total IgG. publication-title: Epidemiol Infect doi: 10.1017/S0950268899002046 – ident: zoi200960r26 doi: 10.1101/2020.07.15.20131789 – volume: 12 start-page: 230 year: 2018 ident: zoi200960r68 article-title: Increasing role of maternal immune activation in neurodevelopmental disorders. publication-title: Front Behav Neurosci doi: 10.3389/fnbeh.2018.00230 – volume: 195 start-page: 139 issue: 2 year: 2019 ident: zoi200960r60 article-title: The impact of timing of maternal influenza immunization on infant antibody levels at birth. publication-title: Clin Exp Immunol doi: 10.1111/cei.2019.195.issue-2 – volume: 32 start-page: 5787 issue: 44 year: 2014 ident: zoi200960r61 article-title: The effect of timing of maternal tetanus, diphtheria, and acellular pertussis (Tdap) immunization during pregnancy on newborn pertussis antibody levels: a prospective study. publication-title: Vaccine doi: 10.1016/j.vaccine.2014.08.038 – volume: 190 start-page: 335 issue: 2 year: 2004 ident: zoi200960r63 article-title: Prevalence of pertussis antibodies in maternal delivery, cord, and infant serum. publication-title: J Infect Dis doi: 10.1086/jid.2004.190.issue-2 – volume: 37 start-page: 861 issue: 8 year: 2020 ident: zoi200960r18 article-title: Severe COVID-19 during pregnancy and possible vertical transmission. publication-title: Am J Perinatol doi: 10.1055/s-0040-1710050 – volume: 323 start-page: 1843 issue: 18 year: 2020 ident: zoi200960r42 article-title: Detection of SARS-CoV-2 in different types of clinical specimens. publication-title: JAMA – volume: 12 start-page: 12 issue: 2 year: 2020 ident: zoi200960r7 article-title: Potential maternal and infant outcomes from (Wuhan) coronavirus 2019-nCoV infecting pregnant women: lessons from SARS, MERS, and other human coronavirus infections. publication-title: Viruses doi: 10.3390/v12020194 – year: 2020 ident: zoi200960r34 article-title: Detectable serum SARS-CoV-2 viral load (RNAaemia) is closely correlated with drastically elevated interleukin 6 (IL-6) level in critically ill COVID-19 patients. publication-title: Clin Infect Dis – year: 2020 ident: zoi200960r65 article-title: Sustained maternal antibody and cellular immune responses in pregnant women infected with Zika virus and mother to infant transfer of Zika-specific antibodies. publication-title: Am J Reprod Immunol doi: 10.1111/aji.13288 – volume: 69 start-page: 769 issue: 25 year: 2020 ident: zoi200960r1 article-title: Characteristics of women of reproductive age with laboratory-confirmed SARS-CoV-2 infection by pregnancy status—United States, January 22-June 7, 2020. publication-title: MMWR Morb Mortal Wkly Rep doi: 10.15585/mmwr.mm6925a1 – volume: 222 start-page: 521 issue: 6 year: 2020 ident: zoi200960r5 article-title: Coronavirus disease 2019 (COVID-19) pandemic and pregnancy. publication-title: Am J Obstet Gynecol doi: 10.1016/j.ajog.2020.03.021 – volume: 215 start-page: B17 issue: 3 year: 2016 ident: zoi200960r24 article-title: Severe maternal morbidity: screening and review. publication-title: Am J Obstet Gynecol doi: 10.1016/j.ajog.2016.07.050 – volume: 39 start-page: 848 issue: 10 year: 2018 ident: zoi200960r37 article-title: Type III interferons in antiviral defenses at barrier surfaces. publication-title: Trends Immunol doi: 10.1016/j.it.2018.08.008 – volume: 323 start-page: 1846 issue: 18 year: 2020 ident: zoi200960r10 article-title: Possible vertical transmission of SARS-CoV-2 from an infected mother to her newborn. publication-title: JAMA – volume: 353 start-page: 772 issue: 6301 year: 2016 ident: zoi200960r69 article-title: Maternal immune activation: implications for neuropsychiatric disorders. publication-title: Science doi: 10.1126/science.aag3194 – volume: 395 start-page: 809 issue: 10226 year: 2020 ident: zoi200960r9 article-title: Clinical characteristics and intrauterine vertical transmission potential of COVID-19 infection in nine pregnant women: a retrospective review of medical records. publication-title: Lancet doi: 10.1016/S0140-6736(20)30360-3 – volume: 28 start-page: 443 issue: 5 year: 2009 ident: zoi200960r44 article-title: Maternally derived antibodies against Bordetella pertussis antigens pertussis toxin and filamentous hemagglutinin in preterm and full term newborns. publication-title: Pediatr Infect Dis J doi: 10.1097/INF.0b013e318193ead7 – volume: 62 start-page: 829 issue: 7 year: 2016 ident: zoi200960r62 article-title: Maternal immunization earlier in pregnancy maximizes antibody transfer and expected infant seropositivity against pertussis. publication-title: Clin Infect Dis doi: 10.1093/cid/ciw027 – volume: 223 start-page: 91.e1 issue: 1 year: 2020 ident: zoi200960r17 article-title: Evidence for and against vertical transmission for severe acute respiratory syndrome coronavirus 2. publication-title: Am J Obstet Gynecol doi: 10.1016/j.ajog.2020.04.039 – ident: zoi200960r23 – volume: 33 start-page: 2092 issue: 11 year: 2020 ident: zoi200960r31 article-title: SARS-CoV-2 can infect the placenta and is not associated with specific placental histopathology: a series of 19 placentas from COVID-19-positive mothers. publication-title: Mod Pathol doi: 10.1038/s41379-020-0639-4 – ident: zoi200960r27 – volume: 9 start-page: 2186 year: 2018 ident: zoi200960r70 article-title: Prenatal immune and endocrine modulators of offspring’s brain development and cognitive functions later in life. publication-title: Front Immunol doi: 10.3389/fimmu.2018.02186 – volume: 13 issue: 3 year: 2019 ident: zoi200960r64 article-title: Perinatal analyses of Zika- and dengue virus–specific neutralizing antibodies: a microcephaly case-control study in an area of high dengue endemicity in Brazil. publication-title: PLoS Negl Trop Dis doi: 10.1371/journal.pntd.0007246 – year: 2020 ident: zoi200960r14 article-title: Detection of SARS-COV-2 in placental and fetal membrane samples. publication-title: Am J Obstet Gynecol MFM doi: 10.1016/j.ajogmf.2020.100133 – volume: 86 start-page: 328 issue: 4 year: 2009 ident: zoi200960r57 article-title: An interspecies comparison of placental antibody transfer: new insights into developmental toxicity testing of monoclonal antibodies. publication-title: Birth Defects Res B Dev Reprod Toxicol doi: 10.1002/bdrb.v86:4 – volume: 311 start-page: 1760 issue: 17 year: 2014 ident: zoi200960r45 article-title: Safety and immunogenicity of tetanus diphtheria and acellular pertussis (Tdap) immunization during pregnancy in mothers and infants: a randomized clinical trial. publication-title: JAMA doi: 10.1001/jama.2014.3633 – volume: 73 start-page: 1063 issue: 6 year: 2005 ident: zoi200960r47 article-title: Differences in dengue severity in infants, children, and adults in a 3-year hospital-based study in Nicaragua. publication-title: Am J Trop Med Hyg doi: 10.4269/ajtmh.2005.73.1063 – volume: 181 start-page: 271 issue: 2 year: 2020 ident: zoi200960r32 article-title: SARS-CoV-2 cell entry depends on ACE2 and TMPRSS2 and is blocked by a clinically proven protease inhibitor. publication-title: Cell doi: 10.1016/j.cell.2020.02.052 – volume: 49 start-page: 418 issue: 5 year: 2020 ident: zoi200960r16 article-title: Pregnancy with new coronavirus infection: clinical characteristics and placental pathological analysis of three cases publication-title: Zhonghua Bing Li Xue Za Zhi – volume: 130 start-page: 511 issue: 3 year: 2017 ident: zoi200960r25 article-title: Neonatal morbidity of small- and large-for-gestational-age neonates born at term in uncomplicated pregnancies. publication-title: Obstet Gynecol doi: 10.1097/AOG.0000000000002199 – volume: 196 start-page: 550 issue: 4 year: 2007 ident: zoi200960r50 article-title: Maternal HIV infection and placental malaria reduce transplacental antibody transfer and tetanus antibody levels in newborns in Kenya. publication-title: J Infect Dis doi: 10.1086/522499 – ident: zoi200960r22 – volume: 324 start-page: 705 issue: 7 year: 2020 ident: zoi200960r2 article-title: Change in the incidence of stillbirth and preterm delivery during the COVID-19 pandemic. publication-title: JAMA doi: 10.1001/jama.2020.12746 – volume: 194 start-page: 1570 issue: 11 year: 2006 ident: zoi200960r48 article-title: Dengue virus infections in the first 2 years of life and the kinetics of transplacentally transferred dengue neutralizing antibodies in Thai children. publication-title: J Infect Dis doi: 10.1086/jid.2006.194.issue-11 – year: 2020 ident: zoi200960r13 article-title: Vertical transmission of COVID-19: SARS-CoV-2 RNA on the fetal side of the placenta in pregnancies with COVID-19 positive mothers and neonates at birth. publication-title: Am J Obstet Gynecol MFM – volume: 14 start-page: 22 issue: 1 year: 2012 ident: zoi200960r30 article-title: RNAscope: a novel in situ RNA analysis platform for formalin-fixed, paraffin-embedded tissues. publication-title: J Mol Diagn doi: 10.1016/j.jmoldx.2011.08.002 – volume: 69 start-page: 1081 issue: 32 year: 2020 ident: zoi200960r53 article-title: Hospitalization rates and characteristics of children aged <18 years hospitalized with laboratory-confirmed COVID-19—COVID-NET, 14 states, March 1-July 25, 2020. publication-title: MMWR Morb Mortal Wkly Rep doi: 10.15585/mmwr.mm6932e3 – volume: 383 start-page: 494 issue: 5 year: 2020 ident: zoi200960r41 article-title: Swabs collected by patients or health care workers for SARS-CoV-2 testing. publication-title: N Engl J Med doi: 10.1056/NEJMc2016321 – volume: 139 year: 2020 ident: zoi200960r4 article-title: Why are pregnant women susceptible to COVID-19? an immunological viewpoint. publication-title: J Reprod Immunol doi: 10.1016/j.jri.2020.103122 – volume: 111 start-page: 14506 issue: 40 year: 2014 ident: zoi200960r36 article-title: Enhanced natural killer-cell and T-cell responses to influenza A virus during pregnancy. publication-title: Proc Natl Acad Sci U S A doi: 10.1073/pnas.1416569111 – volume: 395 start-page: 497 issue: 10223 year: 2020 ident: zoi200960r35 article-title: Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China. publication-title: Lancet doi: 10.1016/S0140-6736(20)30183-5 – volume: 13 issue: 8 year: 2019 ident: zoi200960r66 article-title: Efficient transplacental IgG transfer in women infected with Zika virus during pregnancy. publication-title: PLoS Negl Trop Dis doi: 10.1371/journal.pntd.0007648 – volume: 58 start-page: 58 issue: 6 year: 2020 ident: zoi200960r40 article-title: Nasal swab sampling for SARS-CoV-2: a convenient alternative in times of nasopharyngeal swab shortage. publication-title: J Clin Microbiol doi: 10.1128/JCM.00721-20 – volume: 136 start-page: 300 issue: 2 year: 2020 ident: zoi200960r56 article-title: Prevalence and severity of coronavirus disease 2019 (COVID-19) illness in symptomatic pregnant and postpartum women stratified by Hispanic ethnicity. publication-title: Obstet Gynecol doi: 10.1097/AOG.0000000000004005 – volume: 11 start-page: 3572 issue: 1 year: 2020 ident: zoi200960r20 article-title: Transplacental transmission of SARS-CoV-2 infection. publication-title: Nat Commun doi: 10.1038/s41467-020-17436-6 – ident: zoi200960r21 – volume: 154 start-page: 23 issue: 1 year: 2020 ident: zoi200960r15 article-title: Placental pathology in COVID-19. publication-title: Am J Clin Pathol doi: 10.1093/ajcp/aqaa089 – year: 2020 ident: zoi200960r3 article-title: The tragedy of COVID-19 in Brazil: 124 maternal deaths and counting. publication-title: Int J Gynaecol Obstet doi: 10.1002/ijgo.13300 – volume: 323 start-page: 1848 issue: 18 year: 2020 ident: zoi200960r19 article-title: Antibodies in infants born to mothers with COVID-19 pneumonia. publication-title: JAMA – volume: 16 start-page: 401 issue: 3 year: 2005 ident: zoi200960r54 article-title: Transport of maternal immunoglobulins through the human placental barrier in normal pregnancy and during inflammation. publication-title: Int J Mol Med – volume: 581 start-page: 465 issue: 7809 year: 2020 ident: zoi200960r38 article-title: Virological assessment of hospitalized patients with COVID-2019. publication-title: Nature doi: 10.1038/s41586-020-2196-x – volume: 26 start-page: 2491 issue: 10 year: 2020 ident: zoi200960r46 article-title: Disappearance of SARS-CoV-2 antibodies in infants born to women with COVID-19, Wuhan, China. publication-title: Emerg Infect Dis doi: 10.3201/eid2610.202328 – volume: 11 start-page: 1672 year: 2020 ident: zoi200960r6 article-title: Pregnancy, viral infection, and COVID-19. publication-title: Front Immunol doi: 10.3389/fimmu.2020.01672 – volume: 140 start-page: 698 issue: 7 year: 2016 ident: zoi200960r28 article-title: Sampling and definitions of placental lesions: Amsterdam Placental Workshop Group consensus statement. publication-title: Arch Pathol Lab Med doi: 10.5858/arpa.2015-0225-CC – volume: 6 issue: 6 year: 2019 ident: zoi200960r52 article-title: Reduced transplacental transfer of antimalarial antibodies in Kenyan HIV-exposed uninfected infants. publication-title: Open Forum Infect Dis doi: 10.1093/ofid/ofz237 – volume: 23 start-page: 177 issue: 3 year: 2020 ident: zoi200960r8 article-title: Placental pathology in Covid-19 positive mothers: preliminary findings. publication-title: Pediatr Dev Pathol doi: 10.1177/1093526620925569 – ident: zoi200960r11 – year: 2020 ident: zoi200960r39 article-title: Sensitivity of nasopharyngeal swabs and saliva for the detection of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). publication-title: Clin Infect Dis doi: 10.1093/cid/ciaa848 – volume: 8 start-page: 8 year: 2019 ident: zoi200960r29 article-title: Single-cell sequencing of neonatal uterus reveals an Misr2+ endometrial progenitor indispensable for fertility. publication-title: Elife doi: 10.7554/eLife.46349 – reference: 33351080 - JAMA Netw Open. 2020 Dec 1;3(12):e2030564 |
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| Snippet | Biological data are lacking with respect to risk of vertical transmission and mechanisms of fetoplacental protection in maternal severe acute respiratory... Importance Biological data are lacking with respect to risk of vertical transmission and mechanisms of fetoplacental protection in maternal severe acute... This cohort study examines maternal and neonatal severe acute respiratory syndrome coronavirus 2 viral load, transplacental antibody transfer, and placental... |
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| SubjectTerms | Adult Angiotensin-Converting Enzyme 2 - metabolism Antibodies Antibodies, Viral - immunology Case-Control Studies Cohort Studies Coronavirus Nucleocapsid Proteins - immunology Coronaviruses COVID-19 COVID-19 - blood COVID-19 - immunology COVID-19 - transmission COVID-19 Serological Testing Enzymes Female Fetal Blood - immunology Fetal Blood - virology Humans Immunity, Maternally-Acquired - immunology Immunoglobulin G - immunology Immunoglobulin M - immunology Infant, Newborn Infections Infectious Disease Transmission, Vertical - statistics & numerical data Influenza Influenza A virus - immunology Male Obstetrics and Gynecology Online Only Original Investigation Phosphoproteins - immunology Placenta - metabolism Placenta - pathology Placenta - virology Pregnancy Pregnancy Complications, Infectious - blood Pregnancy Complications, Infectious - immunology Prospective Studies Receptors, Coronavirus - metabolism RNA, Viral - metabolism SARS-CoV-2 - immunology Serine Endopeptidases - metabolism Severe acute respiratory syndrome coronavirus 2 Severity of Illness Index Spike Glycoprotein, Coronavirus - immunology Viral Load Womens health |
| Title | Assessment of Maternal and Neonatal SARS-CoV-2 Viral Load, Transplacental Antibody Transfer, and Placental Pathology in Pregnancies During the COVID-19 Pandemic |
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