Endogenous Deficiency of Glutathione as the Most Likely Cause of Serious Manifestations and Death in COVID-19 Patients

• Published in: ACS infectious diseases Vol. 6; no. 7; pp. 1558 - 1562
• Main Author: Polonikov, Alexey
• Format: Journal Article
• Language: English
• Published: United States American Chemical Society 10.07.2020
• Subjects: Adult; Anti-Inflammatory Agents - blood; Anti-Inflammatory Agents - pharmacology; Anticoagulants - blood; Anticoagulants - pharmacology; Antioxidants - pharmacology; Antiviral Agents - blood; Antiviral Agents - pharmacology; Betacoronavirus - drug effects; Betacoronavirus - physiology; Coronavirus Infections - blood; Coronavirus Infections - mortality; Coronavirus Infections - pathology; Coronavirus Infections - virology; COVID-19; Disease Susceptibility; Feasibility Studies; Female; Glutathione - blood; Glutathione - deficiency; Glutathione - pharmacology; Humans; Middle Aged; Oxidative Stress - drug effects; Pandemics; Pneumonia, Viral - blood; Pneumonia, Viral - mortality; Pneumonia, Viral - pathology; Pneumonia, Viral - virology; Prognosis; Reactive Oxygen Species - blood; Risk Factors; SARS-CoV-2; Severity of Illness Index; Viewpoint; Virus Replication - drug effects; Vitamin D Deficiency - complications

Higher rates of serious illness and death from coronavirus SARS-CoV-2 (COVID-19) infection among older people and those who have comorbidities suggest that age- and disease-related biological processes make such individuals more sensitive to environmental stress factors including infectious agents l...