Ultrasmall Gold Nanoparticles as Carriers for Nucleus-Based Gene Therapy Due to Size-Dependent Nuclear Entry

• Published in: ACS nano Vol. 8; no. 6; pp. 5852 - 5862
• Main Authors: Huo, Shuaidong, Jin, Shubin, Ma, Xiaowei, Xue, Xiangdong, Yang, Keni, Kumar, Anil, Wang, Paul C, Zhang, Jinchao, Hu, Zhongbo, Liang, Xing-Jie
• Format: Journal Article
• Language: English
• Published: United States American Chemical Society 24.06.2014
• Subjects: Breast Neoplasms - therapy; Cancer; Carriers; Cell Nucleus - metabolism; Cell Survival; Cytoplasm - metabolism; Female; Gene expression; Gene Expression Regulation, Neoplastic; Gene Transfer Techniques; Genetic Therapy - methods; Genetic Vectors; Gold; Gold - chemistry; Humans; MCF-7 Cells; Metal Nanoparticles - chemistry; Nanoparticles; Nanostructure; Nanotechnology - methods; Nuclei; Oligonucleotides - chemistry; Promoter Regions, Genetic; Proto-Oncogene Proteins c-myc - chemistry; RNA - chemistry; Therapy; cancer therapy; ultrasmall gold nanoparticles; cancer cell nucleus; gene regulation; size-dependent

The aim of this study was to determine the size-dependent penetration ability of gold nanoparticles and the potential application of ultrasmall gold nanoparticles for intranucleus delivery and therapy. We synthesized gold nanoparticles with diameters of 2, 6, 10, and 16 nm and compared their intrace...