Potent, Orally Bioavailable Diazabicyclic Small-Molecule Mimetics of Second Mitochondria-Derived Activator of Caspases - Peng, Yuefeng; Sun, Haiying; Nikolovska-Coleska, Zaneta; Qiu, Su; Yang, Chao-Yie; Lu, Jianfeng; Cai, Qian; Yi, Han; Kang, Sanmao; Yang, Dajun; Wang, Shaomeng (Journal of medicinal chemistry, 2008)
Keywords: Administration, Oral; Animals; Antineoplastic agents; Baculoviral IAP Repeat-Containing 3 Protein; Biological and medical sciences; Caspase Inhibitors; Cell Line, Tumor; Cell Proliferation - drug effects; Chemistry, Medicinal; Chemistry, Pharmaceutical - methods; Drug Design; Enzyme Inhibitors - chemical synthesis; Enzyme Inhibitors - pharmacology; General aspects; Humans; Inhibitor of Apoptosis Proteins - chemistry; Inhibitory Concentration 50; Life Sciences & Biomedicine; Medical sciences; Mitochondria - enzymology; Mitochondria - metabolism; Pharmacology & Pharmacy; Pharmacology. Drug treatments; Rats; Science & Technology; Ubiquitin-Protein Ligases; X-Linked Inhibitor of Apoptosis Protein - chemistry; CANCER-CELLS; TARGET; SMAC/DIABLO; XIAP BIR3 DOMAIN; STRUCTURAL BASIS; ALPHA-DEPENDENT APOPTOSIS; ANTAGONISTS; BINDING; IAP PROTEINS; STRUCTURE-BASED DESIGN; Human; Rat; Mimetic; Rodentia; Lactam; Oral administration; Bioavailability; In vitro; Second mitochondria derived activator of caspase protein; Biological activity; Vertebrata; Mammalia; Cell line; Apoptosis inhibitory protein; Animal; Mammary gland; Small molecule; Pharmacokinetics; Chemical synthesis; Tumor cell; Apoptosis