Use of Urine Volatile Organic Compounds To Discriminate Tuberculosis Patients from Healthy Subjects

• Published in: Analytical chemistry (Washington) Vol. 83; no. 14; pp. 5526 - 5534
• Main Authors: Banday, Khalid Muzaffar, Pasikanti, Kishore Kumar, Chan, Eric Chun Yong, Singla, Rupak, Rao, Kanury Venkata Subba, Chauhan, Virander Singh, Nanda, Ranjan Kumar
• Format: Journal Article
• Language: English
• Published: Washington, DC American Chemical Society 15.07.2011
• Subjects: Adult; Aged; Analytical chemistry; Bacterial diseases; Biological and medical sciences; Chemistry; Chromatographic methods and physical methods associated with chromatography; Exact sciences and technology; Female; Gas chromatographic methods; Gas chromatography; Gas Chromatography-Mass Spectrometry - methods; Human bacterial diseases; Humans; Infectious diseases; Lung cancer; Male; Mass spectrometry; Medical diagnosis; Medical sciences; Middle Aged; Multivariate Analysis; Mycobacterium; Organic compounds; Reproducibility of Results; Spectrometric and optical methods; Tuberculosis; Tuberculosis - diagnosis; Tuberculosis - urine; Tuberculosis and atypical mycobacterial infections; Urine; VOCs; Volatile organic compounds; Volatile Organic Compounds - urine; Xylene; Young Adult; Urine; Lung disease; Volatile organic compound; Mycobacterial infection; Acetate; Marker; Method; Pentanols; Infection; Characterization; Array; Gas chromatography; Molecules; Tuberculosis; Xylene; Bacteriosis; Headspace; Diagnosis; Mass spectrometry

Development of noninvasive methods for tuberculosis (TB) diagnosis, with the potential to be administered in field situations, remains as an unmet challenge. A wide array of molecules are present in urine and reflect the pathophysiological condition of a subject. With infection, an alteration in the...