Erythromycin Enhances CD4^+Foxp3^+ Regulatory T-Cell Responses in a Rat Model of Smoke-Induced Lung Inflammation

• Published in: Mediators of Inflammation Vol. 2012; no. 2012; pp. 725 - 733
• Main Authors: Deng, Jing-Min, Li, Mei-Hua, Zhang, Jian-Quan, He, Zhi-Yi, Huang, Qiu-Ping, Zhong, Xiao-Ning, Qiu, Shi-Lin, Bai, Jing, Liu, Guang-Nan
• Format: Journal Article
• Language: English
• Published: Cairo, Egypt Hindawi Limiteds 01.01.2012; Hindawi Publishing Corporation; Wiley
• Subjects: Animals; CD4-Positive T-Lymphocytes - metabolism; Enzyme-Linked Immunosorbent Assay; Erythromycin - therapeutic use; Forkhead Transcription Factors - metabolism; Interleukin-8 - metabolism; Pneumonia - chemically induced; Pneumonia - drug therapy; Pneumonia - immunology; Pneumonia - metabolism; Rats; Reverse Transcriptase Polymerase Chain Reaction; Smoking - adverse effects; Tumor Necrosis Factor-alpha - metabolism

Heavy smoking can induce airway inflammation and emphysema. Macrolides can modulate inflammation and effector T-cell response in the lungs. However, there is no information on whether erythromycin can modulate regulatory T-cell (Treg) response. This study is aimed at examining the impact of erythrom...