Induced CYP1A2 Activity as a Phenotypic Biomarker in Humans Highly Exposed to Certain PCBs/PCDFs

• Published in: Environmental science & technology Vol. 40; no. 19; pp. 6176 - 6180
• Main Authors: Lambert, George H, Needham, Larry L, Turner, Wayman, Lai, Te Jen, Patterson, Donald G, Guo, Y. Leon
• Format: Journal Article
• Language: English
• Published: Washington, DC American Chemical Society 01.10.2006
• Subjects: Adult; Aged; Benzofurans - blood; Biological and medical sciences; Biomarkers; Biomarkers - blood; Breath Tests; Caffeine - pharmacokinetics; Carbon Isotopes - analysis; Carbon Isotopes - metabolism; Cytochrome P-450 CYP1A2 - metabolism; Dibenzofurans, Polychlorinated; Dioxins; Environmental Pollutants - blood; Environmental pollutants toxicology; Enzymes; Female; General aspects; Genetic markers; Human exposure; Human subjects; Humans; Male; Medical sciences; Middle Aged; Oryza sativa; PCB; Phenotype; Polychlorinated biphenyls; Polychlorinated Biphenyls - blood; Smoking - metabolism; Toxicology; Asia; Taiwan; Human; Isozyme; Toxicity; Cytochrome P450; Biological marker; Polychlorobiphenyl; Pollutant; Phenotype; Health and environment; Cohort study; Toxicogenetics; Environment; Public health; Food; Chemical contamination; Rice

Polychlorinated biphenyls (PCBs), dibenzo-p-dioxins (PCDDs), and dibenzofurans (PCDFs) continue to be a worldwide public health concern due to their levels in the environment and humans, and associated adverse health effects. In animals, one of the most sensitive effects of physiologically significa...