Joint Contributions of Rare Copy Number Variants and Common SNPs to Risk for Schizophrenia

• Published in: The American journal of psychiatry Vol. 176; no. 1; pp. 29 - 35
• Main Authors: Bergen, Sarah E, Ploner, Alexander, Howrigan, Daniel, O’Donovan, Michael C, Smoller, Jordan W, Sullivan, Patrick F, Sebat, Jonathan, Neale, Benjamin, Kendler, Kenneth S
• Format: Journal Article
• Language: English
• Published: United States American Psychiatric Association 01.01.2019
• Subjects: Adult; Algorithms; DNA Copy Number Variations; Female; Genetic Predisposition to Disease; Genetics; Genome-Wide Association Study; Humans; Male; Multifactorial Inheritance; Polymorphism; Polymorphism, Single Nucleotide; Risk Assessment - methods; Risk factors; Schizophrenia; Schizophrenia - genetics; Structural Variation; Schizophrenia Risk Profile Score; Genome-wide Association Study; Copy Number Variation

Objective:Both rare copy number variants (CNVs) and common single-nucleotide polymorphisms (SNPs) contribute to liability to schizophrenia, but their etiological relationship has not been fully elucidated. The authors evaluated an additive model whereby risk of schizophrenia requires less contributi...