Contrasting Modes of New World Arenavirus Neutralization by Immunization-Elicited Monoclonal Antibodies

• Published in: mBio Vol. 13; no. 2; p. e0265021
• Main Authors: Ng, Weng M, Sahin, Mehmet, Krumm, Stefanie A, Seow, Jeffrey, Zeltina, Antra, Harlos, Karl, Paesen, Guido C, Pinschewer, Daniel D, Doores, Katie J, Bowden, Thomas A
• Format: Journal Article
• Language: English
• Published: United States American Society for Microbiology 26.04.2022
• Subjects: Animals; Antibodies, Monoclonal; Antibodies, Neutralizing; antibody response; antibody-mediated neutralization; arenavirus; Arenaviruses, New World - metabolism; glycoprotein; Immunization; Junin virus - metabolism; Mice; monoclonal antibody; Receptors, Transferrin; Research Article; Structural Biology; structure; Tyrosine; arenavirus; antibody response; immunization; glycoprotein; structural biology; antibody-mediated neutralization; host-cell interactions; monoclonal antibody; structure

Transmission of the New World hemorrhagic fever arenaviruses Junín virus (JUNV) and Machupo virus (MACV) to humans is facilitated, in part, by the interaction between the arenavirus GP1 glycoprotein and the human transferrin receptor 1 (hTfR1). We utilize a mouse model of live-attenuated immunizatio...