An On-Chip, Multichannel Droplet Sorter Using Standing Surface Acoustic Waves
The emerging field of droplet microfluidics requires effective on-chip handling and sorting of droplets. In this work, we demonstrate a microfluidic device that is capable of sorting picoliter water-in-oil droplets into multiple outputs using standing surface acoustic waves (SSAW). This device integ...
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| Published in | Analytical chemistry (Washington) Vol. 85; no. 11; pp. 5468 - 5474 |
|---|---|
| Main Authors | , , , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
United States
American Chemical Society
04.06.2013
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| Subjects | |
| Online Access | Get full text |
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| Abstract | The emerging field of droplet microfluidics requires effective on-chip handling and sorting of droplets. In this work, we demonstrate a microfluidic device that is capable of sorting picoliter water-in-oil droplets into multiple outputs using standing surface acoustic waves (SSAW). This device integrates a single-layer microfluidic channel with interdigital transducers (IDTs) to achieve on-chip droplet generation and sorting. Within the SSAW field, water-in-oil droplets experience an acoustic radiation force and are pushed toward the acoustic pressure node. As a result, by tuning the frequency of the SSAW excitation, the position of the pressure nodes can be changed and droplets can be sorted to different outlets at rates up to 222 droplets s–1. With its advantages in simplicity, controllability, versatility, noninvasiveness, and capability to be integrated with other on-chip components such as droplet manipulation and optical detection units, the technique presented here could be valuable for the development of droplet-based micro total analysis systems (μTAS). |
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| AbstractList | The emerging field of droplet microfluidics requires effective on-chip handling and sorting of droplets. In this work, we demonstrate a microfluidic device that is capable of sorting picoliter water-in-oil droplets into multiple outputs using standing surface acoustic waves (SSAW). This device integrates a single-layer microfluidic channel with interdigital transducers (IDTs) to achieve on-chip droplet generation and sorting. Within the SSAW field, water-in-oil droplets experience an acoustic radiation force and are pushed toward the acoustic pressure node. As a result, by tuning the frequency of the SSAW excitation, the position of the pressure nodes can be changed and droplets can be sorted to different outlets at rates up to 222 droplets s(-1). With its advantages in simplicity, controllability, versatility, noninvasiveness, and capability to be integrated with other on-chip components such as droplet manipulation and optical detection units, the technique presented here could be valuable for the development of droplet-based micro total analysis systems (μTAS). The emerging field of droplet microfluidics requires effective on-chip handling and sorting of droplets. In this work, we demonstrate a microfluidic device that is capable of sorting picoliter water-in-oil droplets into multiple outputs using standing surface acoustic waves (SSAW). This device integrates a single-layer microfluidic channel with interdigital transducers (IDTs) to achieve on-chip droplet generation and sorting. Within the SSAW field, water-in-oil droplets experience an acoustic radiation force and are pushed toward the acoustic pressure node. As a result, by tuning the frequency of the SSAW excitation, the position of the pressure nodes can be changed and droplets can be sorted to different outlets at rates up to 222 droplets s–¹. With its advantages in simplicity, controllability, versatility, noninvasiveness, and capability to be integrated with other on-chip components such as droplet manipulation and optical detection units, the technique presented here could be valuable for the development of droplet-based micro total analysis systems (μTAS). The emerging field of droplet microfluidics requires effective on-chip handling and sorting of droplets. In this work, we demonstrate a microfluidic device that is capable of sorting picoliter water-in-oil droplets into multiple outputs using standing surface acoustic waves (SSAW). This device integrates a single-layer microfluidic channel with interdigital transducers (IDTs) to achieve on-chip droplet generation and sorting. Within the SSAW field, water-in-oil droplets experience an acoustic radiation force and are pushed toward the acoustic pressure node. As a result, by tuning the frequency of the SSAW excitation, the position of the pressure nodes can be changed and droplets can be sorted to different outlets at rates up to 222 droplets s^sup -1^. With its advantages in simplicity, controllability, versatility, noninvasiveness, and capability to be integrated with other on-chip components such as droplet manipulation and optical detection units, the technique presented here could be valuable for the development of droplet-based micro total analysis systems (μTAS). [PUBLICATION ABSTRACT] The emerging field of droplet microfluidics requires effective on-chip handling and sorting of droplets. In this work, we demonstrate a microfluidic device that is capable of sorting picoliter water-in-oil droplets into multiple outputs using standing surface acoustic waves (SSAW). This device integrates a single-layer microfluidic channel with interdigital transducers (IDTs) to achieve on-chip droplet generation and sorting. Within the SSAW field, water-in-oil droplets experience an acoustic radiation force and are pushed towards the acoustic pressure node. As a result, by tuning the frequency of the SSAW excitation, the position of the pressure nodes can be changed and droplets can be sorted to different outlets at rates up to 222 droplets s −1 . With its advantages in simplicity, controllability, versatility, non-invasiveness, and capability to be integrated with other on-chip components such as droplet manipulation and optical detection units, the technique presented here could be valuable for the development of droplet-based micro total analysis systems (μTAS). The emerging field of droplet microfluidics requires effective on-chip handling and sorting of droplets. In this work, we demonstrate a microfluidic device that is capable of sorting picoliter water-in-oil droplets into multiple outputs using standing surface acoustic waves (SSAW). This device integrates a single-layer microfluidic channel with interdigital transducers (IDTs) to achieve on-chip droplet generation and sorting. Within the SSAW field, water-in-oil droplets experience an acoustic radiation force and are pushed toward the acoustic pressure node. As a result, by tuning the frequency of the SSAW excitation, the position of the pressure nodes can be changed and droplets can be sorted to different outlets at rates up to 222 droplets s(-1). With its advantages in simplicity, controllability, versatility, noninvasiveness, and capability to be integrated with other on-chip components such as droplet manipulation and optical detection units, the technique presented here could be valuable for the development of droplet-based micro total analysis systems (μTAS).The emerging field of droplet microfluidics requires effective on-chip handling and sorting of droplets. In this work, we demonstrate a microfluidic device that is capable of sorting picoliter water-in-oil droplets into multiple outputs using standing surface acoustic waves (SSAW). This device integrates a single-layer microfluidic channel with interdigital transducers (IDTs) to achieve on-chip droplet generation and sorting. Within the SSAW field, water-in-oil droplets experience an acoustic radiation force and are pushed toward the acoustic pressure node. As a result, by tuning the frequency of the SSAW excitation, the position of the pressure nodes can be changed and droplets can be sorted to different outlets at rates up to 222 droplets s(-1). With its advantages in simplicity, controllability, versatility, noninvasiveness, and capability to be integrated with other on-chip components such as droplet manipulation and optical detection units, the technique presented here could be valuable for the development of droplet-based micro total analysis systems (μTAS). |
| Author | Chen, Yuchao Ding, Xiaoyun Lapsley, Michael Ian Cameron, Craig E Huang, Tony Jun Lin, Sz-Chin Steven Wang, Lin Guo, Feng Li, Sixing McCoy, J. Philip |
| AuthorAffiliation | Cell and Developmental Biology (CDB) Graduate Program Ascent Bio-Nano Technologies Inc National Heart, Lung, and Blood Institute at NIH The Huck Institutes of the Life Sciences Department of Biochemistry and Molecular Biology The Pennsylvania State University Department of Engineering Science and Mechanics |
| AuthorAffiliation_xml | – name: The Huck Institutes of the Life Sciences – name: Cell and Developmental Biology (CDB) Graduate Program – name: The Pennsylvania State University – name: Ascent Bio-Nano Technologies Inc – name: Department of Engineering Science and Mechanics – name: National Heart, Lung, and Blood Institute at NIH – name: Department of Biochemistry and Molecular Biology – name: b Cell and Developmental Biology (CDB) Graduate Program, The Huck Institutes of the Life Sciences, The Pennsylvania State University, University Park, PA 16802 – name: a Department of Engineering Science and Mechanics, The Pennsylvania State University, University Park, PA 16802, USA – name: d National Heart, Lung, and Blood Institute at NIH, Bethesda, MD 20892 – name: c Ascent Bio-Nano Technologies Inc., State College, PA 16801 – name: e Department of Biochemistry and Molecular Biology, The Pennsylvania State University, University Park, PA 16802 |
| Author_xml | – sequence: 1 givenname: Sixing surname: Li fullname: Li, Sixing – sequence: 2 givenname: Xiaoyun surname: Ding fullname: Ding, Xiaoyun – sequence: 3 givenname: Feng surname: Guo fullname: Guo, Feng – sequence: 4 givenname: Yuchao surname: Chen fullname: Chen, Yuchao – sequence: 5 givenname: Michael Ian surname: Lapsley fullname: Lapsley, Michael Ian – sequence: 6 givenname: Sz-Chin Steven surname: Lin fullname: Lin, Sz-Chin Steven – sequence: 7 givenname: Lin surname: Wang fullname: Wang, Lin – sequence: 8 givenname: J. Philip surname: McCoy fullname: McCoy, J. Philip – sequence: 9 givenname: Craig E surname: Cameron fullname: Cameron, Craig E – sequence: 10 givenname: Tony Jun surname: Huang fullname: Huang, Tony Jun email: junhuang@psu.edu |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/23647057$$D View this record in MEDLINE/PubMed |
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| CODEN | ANCHAM |
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| Snippet | The emerging field of droplet microfluidics requires effective on-chip handling and sorting of droplets. In this work, we demonstrate a microfluidic device... |
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| StartPage | 5468 |
| SubjectTerms | Analytical chemistry droplets Equipment Design Hydrodynamics Microfluidic Analytical Techniques - instrumentation Microfluidic Analytical Techniques - methods Oils - chemistry Radiation Sound sounds Surface acoustic waves Surface Properties systems analysis Transducers transducers (equipment) Water - chemistry |
| Title | An On-Chip, Multichannel Droplet Sorter Using Standing Surface Acoustic Waves |
| URI | http://dx.doi.org/10.1021/ac400548d https://www.ncbi.nlm.nih.gov/pubmed/23647057 https://www.proquest.com/docview/1365656370 https://www.proquest.com/docview/1365050540 https://www.proquest.com/docview/2000305348 https://pubmed.ncbi.nlm.nih.gov/PMC3988909 |
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