Molecular Details of Protein Condensates Probed by Microsecond Long Atomistic Simulations

• Published in: The journal of physical chemistry. B Vol. 124; no. 51; pp. 11671 - 11679
• Main Authors: Zheng, Wenwei, Dignon, Gregory L, Jovic, Nina, Xu, Xichen, Regy, Roshan M, Fawzi, Nicolas L, Kim, Young C, Best, Robert B, Mittal, Jeetain
• Format: Journal Article
• Language: English
• Published: United States American Chemical Society 24.12.2020
• Subjects: B: Biophysics; Physical Chemistry of Biological Systems and Biomolecules; Biochemical Phenomena; condensates; hydrogen; Hydrophobic and Hydrophilic Interactions; hydrophobicity; Intrinsically Disordered Proteins; Organelles; Phase Transition; separation; water content

The formation of membraneless organelles in cells commonly occurs via liquid–liquid phase separation (LLPS) and is in many cases driven by multivalent interactions between intrinsically disordered proteins (IDPs). Investigating the nature of these interactions, and their effect on dynamics within th...