Regional White Matter Hyperintensity Burden in Automated Segmentation Distinguishes Late-Life Depressed Subjects From Comparison Subjects Matched for Vascular Risk Factors

• Published in: The American journal of psychiatry Vol. 165; no. 4; pp. 524 - 532
• Main Authors: Sheline, Yvette I., Price, Joseph L., Vaishnavi, S. Neil, Mintun, Mark A., Barch, Deanna M., Epstein, Adrian A., Wilkins, Consuelo H., Snyder, Abraham Z., Couture, Lars, Schechtman, Kenneth, McKinstry, Robert C.
• Format: Journal Article
• Language: English
• Published: Washington, DC American Psychiatric Association 01.04.2008
• Subjects: Adult and adolescent clinical studies; Aged; Algorithms; Biological and medical sciences; Brain; Brain - pathology; Brain Mapping; Cardiovascular disease; Cerebrovascular Disorders - diagnosis; Cerebrovascular Disorders - epidemiology; Cerebrovascular Disorders - pathology; Clinical outcomes; Cognition & reasoning; Cognition Disorders - diagnosis; Cognition Disorders - epidemiology; Cognition Disorders - pathology; Comorbidity; Depression; Depressive Disorder, Major - diagnosis; Depressive Disorder, Major - epidemiology; Depressive Disorder, Major - pathology; Diagnosis, Differential; Female; Geriatrics; Humans; Magnetic Resonance Imaging - methods; Magnetic Resonance Imaging - statistics & numerical data; Male; Medical disorders; Medical sciences; Mental depression; Mood disorders; Neural Pathways; Neuropsychological Tests - statistics & numerical data; Psychiatry; Psychology. Psychoanalysis. Psychiatry; Psychopathology. Psychiatry; Risk Factors; Smoking; Studies; Human; Mood disorder; Volumetric analysis; Executive function; Segmentation; Central nervous system; Depression; Cognition; Nuclear magnetic resonance imaging; White matter; Encephalon; Risk factor; Episodic memory; Elderly; Hyperintensity
• ISSN: 0002-953X; 1535-7228
• DOI: 10.1176/appi.ajp.2007.07010175

Objective: Segmented brain white matter hyperintensities were compared between subjects with late-life depression and age-matched subjects with similar vascular risk factor scores. Correlations between neuropsychological performance and whole brain-segmented white matter hyperintensities and white a...