Biosynthetic Pathway for the Epipolythiodioxopiperazine Acetylaranotin in Aspergillus terreus Revealed by Genome-Based Deletion Analysis

• Published in: Journal of the American Chemical Society Vol. 135; no. 19; pp. 7205 - 7213
• Main Authors: Guo, Chun-Jun, Yeh, Hsu-Hua, Chiang, Yi-Ming, Sanchez, James F, Chang, Shu-Ling, Bruno, Kenneth S, Wang, Clay C. C
• Format: Journal Article
• Language: English
• Published: United States American Chemical Society 15.05.2013
• Subjects: Aspergillus - chemistry; Aspergillus - enzymology; Aspergillus - genetics; Aspergillus - metabolism; Aspergillus terreus; biochemical pathways; biosynthesis; Biosynthetic Pathways; chemical analysis; diketopiperazines; engineering; fungi; Gene Deletion; genes; Genome, Fungal; Multigene Family; mutants; Oxepins - chemistry; Oxepins - metabolism; Piperazines - chemistry; Piperazines - metabolism; secondary metabolites

Epipolythiodioxopiperazines (ETPs) are a class of fungal secondary metabolites derived from diketopiperazines. Acetylaranotin belongs to one structural subgroup of ETPs characterized by the presence of a seven-membered 4,5-dihydrooxepine ring. Defining the genes involved in acetylaranotin biosynthes...