Morphogenesis of Bullet-Shaped Rabies Virus Particles Regulated by TSG101

• Published in: Journal of virology Vol. 97; no. 5; p. e0043823
• Main Authors: Itakura, Yukari, Tabata, Koshiro, Saito, Takeshi, Intaruck, Kittiya, Kawaguchi, Nijiho, Kishimoto, Mai, Torii, Shiho, Kobayashi, Shintaro, Ito, Naoto, Harada, Michiko, Inoue, Satoshi, Maeda, Ken, Takada, Ayato, Hall, William W., Orba, Yasuko, Sawa, Hirofumi, Sasaki, Michihito
• Format: Journal Article
• Language: English
• Published: United States American Society for Microbiology 31.05.2023
• Subjects: Animals; Cell Line; Endosomal Sorting Complexes Required for Transport - genetics; Endosomal Sorting Complexes Required for Transport - metabolism; Humans; Morphogenesis; Rabies - metabolism; Rabies virus - genetics; Rabies virus - metabolism; Viral Proteins - genetics; Viral Proteins - metabolism; Virion - metabolism; Virology; Virus Release; Virus-Cell Interactions; L-domain; rabies virus; TSG101; rhabdovirus; ESCRT; matrix protein

Enveloped viruses bud from cells with the host lipid bilayer. Generally, the membrane modulation and abscission are mediated by host ESCRT complexes. Viral protein assembly and virion budding are tightly regulated to enable the proper formation of progeny virions. At this late stage in the virus lif...