Development of blood-brain barrier-penetrating antibodies for neutralizing tick-borne encephalitis virus in the brain - Fukuta, Mizuki; Fukano, Sayo; Maekawa, Naoya; Kobayashi, Shintaro; Okamoto, Shunsuke; Hirano, Minato; Nio-Kobayashi, Junko; Kariwa, Hiroaki; Kawakami, Shigeru; Konnai, Satoru; Yoshii, Kentaro (mSphere, 2025)
Keywords: Animals; Antibodies; Antibodies, Neutralizing - administration & dosage; Antibodies, Neutralizing - immunology; Antibodies, Viral - administration & dosage; Antibodies, Viral - genetics; Antibodies, Viral - immunology; Antiviral agents; Arachnids; Blood-brain barrier; Blood-Brain Barrier - immunology; Blood-Brain Barrier - virology; Brain - virology; C-Terminus; Cell Line; Central nervous system; Drug delivery; Drug delivery systems; Encephalitis; Encephalitis Viruses, Tick-Borne - immunology; Encephalitis, Tick-Borne - therapy; Encephalitis, Tick-Borne - virology; Endothelial cells; Endothelial Cells - virology; Female; Glycoproteins; Humans; Invasiveness; Ligands; Light; Membrane permeability; Mice; Mice, Inbred BALB C; Neurological diseases; Peptide Fragments; Plasmids; Polypeptides; Quality of life; Rabies; rabies virus glycoprotein; recombinant antibody; Recombinant Fusion Proteins - genetics; Recombinant Fusion Proteins - immunology; Research Article; Tick-borne encephalitis; tick-borne encephalitis virus; Viral Proteins - genetics; Viral Proteins - immunology; Virology; Viruses; Japan; blood-brain barrier; rabies virus glycoprotein; recombinant antibody; tick-borne encephalitis virus