Combined Immune Checkpoint Blockade Enhances Antiviral Immunity against Bovine Leukemia Virus

• Published in: Journal of virology Vol. 97; no. 1; p. e0143022
• Main Authors: Nakamura, Hayato, Konnai, Satoru, Okagawa, Tomohiro, Maekawa, Naoya, Sajiki, Yamato, Watari, Kei, Kamitani, Kana, Saito, Maya, Kato, Yukinari, Suzuki, Yasuhiko, Murata, Shiro, Ohashi, Kazuhiko
• Format: Journal Article
• Language: English
• Published: United States American Society for Microbiology 31.01.2023
• Subjects: Animals; Cattle; CD8-Positive T-Lymphocytes - immunology; Enzootic Bovine Leukosis - immunology; Gene Expression Regulation - immunology; Immune Checkpoint Proteins - immunology; Immunology; Interferon-gamma - immunology; Leukemia Virus, Bovine - immunology; Mucins - immunology; Pathogenesis and Immunity; Programmed Cell Death 1 Receptor - immunology; PD-L1; cattle; TIM-3; bovine leukemia virus; lymphoma

Enzootic bovine leukosis caused by bovine leukemia virus (BLV) is an important viral disease in cattle, causing severe economic losses to the cattle industry worldwide. The molecular mechanisms of BLV-host interactions are complex. Bovine leukemia virus (BLV) is a retrovirus that causes enzootic bov...